New shot could tame tough eczema

NCT ID NCT06863961

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This study tests a new drug called Afimkibart (RO7790121) in 160 adults with moderate to severe atopic dermatitis (eczema). Participants receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug improves eczema symptoms by at least 75% after 16 weeks, with safety monitored throughout.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Afimkibart (also called RO7790121), a drug given as a shot under the skin
What this could lead to: If it works, this could point toward a new treatment option for people with moderate to severe eczema that is not well controlled by current therapies.
What could go wrong: This is an early Phase 2 trial with only 160 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS

Contacts and locations

Locations

AMR Fort Myers

Fort Myers, Florida, 33912, United States
Arlington Research Center

Arlington, Texas, 76011, United States
Azienda Ospedaliero Universitaria Policlinico Gaspare Rodolico - San Marco (Presidio G. Rodolico)

Catania, Sicily, 95123, Italy
Azienda Ospedaliero Universitaria delle Marche

Ancona, The Marches, 60126, Italy
Best Skin Research LLC

Camp Hill, Pennsylvania, 17011, United States
Care Access Research - Hoboken

Hoboken, New Jersey, 07030, United States
Central Sooner Research

Oklahoma City, Oklahoma, 73170, United States
Centre de Recherche Saint-Louis

Québec, G1W 4R4, Canada
Centricity Research

London, Ontario, N6A 2C2, Canada
Centricity Research Columbus Dermatology

Columbus, Ohio, 43213, United States
Centro de Estudos em Terapias Inovadoras ? CETI

Curitiba, Paraná, 80030-110, Brazil
Centro de Pesquisa São Lucas

Campinas, São Paulo, 13034-685, Brazil
Centrum Medyczne Pratia Gdynia

Gdynia, 81-338, Poland
Centrum Medyczne Pratia Katowice I

Katowice, 40-081, Poland
Centrum Nowoczesnych Terapii "Dobry Lekarz"

Krakow, 31-011, Poland
Clinica Ibis

Salvador, Estado de Bahia, 41820-020, Brazil
Clinica Universidad de Navarra-Madrid

Madrid, 28027, Spain
Clinica Universitaria de Navarra

Pamplona, Navarre, 31008, Spain
Complejo Hospitalario Universitario de Santiago.

Santiago de Compostela, LA Coruna, 15706, Spain
DRK Krankenhaus Chemnitz-Rabenstein

Chemnitz, Saxony, 09117, Germany
Dawes Fretzin Clinical Res LLC

Indianapolis, Indiana, 46250, United States
DermEdge

Mississauga, Ontario, L4Y 4C5, Canada
DermEffects

London, Ontario, N6H 5L5, Canada
Dermatologikum Hamburg GmbH

Hamburg, 20354, Germany
Dermatology Affiliates Research Institute, LLC

Atlanta, Georgia, 30305, United States
Dermatology Research Associate

Los Angeles, California, 90045, United States
Dermatology Research Institute Inc.

Calgary, Alberta, T2J 7E1, Canada
Fondazione IRCCS CA? Granda Ospedale Maggiore Policlinico

Milan, Lombardy, 20144, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, Emilia-Romagna, 00168, Italy
Forest Hill Dermatology Group

Kew Gardens, New York, 11415, United States
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto Hospital de Base - PPDS

Sao Jose Rio Preto, São Paulo, 15090-000, Brazil
HMCG - Hospital e Maternidade Dr. Christovo da Gama

Santo Andr, São Paulo, 09030-010, Brazil
Hamilton Research, LLC

Alpharetta, Georgia, 30022, United States
Harzklinikum Dorothea Christiane Erxleben GmbH

Quedlinburg, Saxony-Anhalt, 06484, Germany
Hautmedizin Saar

Merzig, Saarland, 66663, Germany
Hopital Charles Nicolle

Rouen, Nord, 76031, France
Hopital Saint Louis

Cedex 10, Paris, 75010, France
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Reina Sofia

Córdoba, 14004, Spain
Hospital de Clnicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Instituto Brasil de Pesquisa Clínica-IBPCLIN S/A

Rio de Janeiro, 20241-180, Brazil
Klinika Ambroziak Dermatologia

Warsaw, 02-953, Poland
Klinisches Studienzentrum

Bad Bentheim, Lower Saxony, 48455, Germany
Lynderm Research Inc

Markham, Ontario, L3P 1X3, Canada
MICS Centrum Medyczne Warszawa

Warsaw, 00-872, Poland
Modern Research Associates

Dallas, Texas, 75231, United States
Olympian Clinical Research

Tampa, Florida, 33615, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Regents of the University of Minnesota

Minneapolis, Minnesota, 55455, United States
Reveal Research Institute

Dallas, Texas, 75235, United States
Revival Research Institute, LLC

Troy, Michigan, 48084, United States
Ryan Clinical Research Inc

Newmarket, Ontario, L3Y 5G8, Canada
Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
Southern Indiana Clinical Trials

New Albany, Indiana, 47150, United States
The Center for Dermatology Clinical Research

Fremont, California, 94538, United States
UCLA Division of Dermatology

Los Angeles, California, 90024, United States
UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu

Botucatu, São Paulo, 18618-686, Brazil
Universitaetsklinikum Freiburg

Freiburg im Breisgau, Baden-Wurttemberg, 79104, Germany
Uniwersytecki Szpital Kliniczny im.Fryderyka Chopina w Rzeszowie

Rzeszów, 35-055, Poland
Weill Cornell Medicine

New York, New York, 10075, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.