New drug combo shows promise for rare eye cancer

NCT ID NCT01979523

First seen Mar 16, 2026 · Last updated May 01, 2026 · Updated 4 times

Summary

This study tested two drug combinations in 42 people with advanced uveal melanoma, a rare eye cancer that has spread. The goal was to see if adding a second drug (GSK2141795) to trametinib could slow cancer growth better than trametinib alone. Participants received either one or both drugs, and researchers tracked how long the cancer stayed under control and what side effects occurred.

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Contacts and locations

Locations

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • Institut Curie Paris

    Paris, 75005, France

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York, 10032, United States

  • The University of Liverpool

    Liverpool, L69 3GA, United Kingdom

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.