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Leqvio safety under the microscope: Real-World data on 585 patients

NCT ID NCT06275724

Ongoing Knowledge-focused Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tracks 585 patients with familial or regular high cholesterol who are already prescribed Leqvio. Researchers will monitor side effects and cholesterol levels over time to see how safe and effective the drug is in everyday use. No new treatment is given—it's purely observational.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

inclisiran (Leqvio)

What this could lead to

If successful, this study will confirm the long-term safety of Leqvio for managing high cholesterol in real-world use.

What could go wrong

This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by other factors.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

familial hypercholesterolemia homozygous familial hypercholesterolemia Hypercholesterolemia hypercholesterolemia, familial, 1 hyperlipidemia Hyperlipoproteinemia Type II

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FAMILIAL HYPERCHOLESTEROLAEMIA HYPERCHOLESTEROLAEMIA

Contacts and locations

Locations

  • Novartis Investigative Site

    Handa, Aichi-ken, 475-0817, Japan

  • Novartis Investigative Site

    Ichinomiya, Aichi-ken, 491-8551, Japan

  • Novartis Investigative Site

    Ichinomiya, Aichi-ken, 494-0001, Japan

  • Novartis Investigative Site

    Komaki, Aichi-ken, 485-8520, Japan

  • Novartis Investigative Site

    Nagoya, Aichi-ken, 4540933, Japan

  • Novartis Investigative Site

    Nagoya, Aichi-ken, 461-0045, Japan

  • Novartis Investigative Site

    Toyoake, Aichi-ken, 4701192, Japan

  • Novartis Investigative Site

    Tsushima, Aichi-ken, 496-0038, Japan

  • Novartis Investigative Site

    Asahi, Chiba, 289-2511, Japan

  • Novartis Investigative Site

    Inzai, Chiba, 270-1694, Japan

  • Novartis Investigative Site

    Urayasu, Chiba, 279-0021, Japan

  • Novartis Investigative Site

    Matsuyama, Ehime, 791-8016, Japan

  • Novartis Investigative Site

    Fukui-shi, Fukui, 910-8526, Japan

  • Novartis Investigative Site

    Fukuoka, Fukuoka, 8140180, Japan

  • Novartis Investigative Site

    Fukuoka, Fukuoka, 815-0082, Japan

  • Novartis Investigative Site

    Kitakyushu, Fukuoka, 800-0031, Japan

  • Novartis Investigative Site

    Kitakyushu, Fukuoka, 8078556, Japan

  • Novartis Investigative Site

    Fukushima, Fukushima, 960-8611, Japan

  • Novartis Investigative Site

    Kōriyama, Fukushima, 963-8501, Japan

  • Novartis Investigative Site

    Shirakawa, Fukushima, 961-0005, Japan

  • Novartis Investigative Site

    Gifu, Gifu, 500-8384, Japan

  • Novartis Investigative Site

    Hiroshima, Hiroshima, 7320053, Japan

  • Novartis Investigative Site

    Kure, Hiroshima, 737-0023, Japan

  • Novartis Investigative Site

    Asahikawa, Hokkaido, 0788211, Japan

  • Novartis Investigative Site

    Asahikawa, Hokkaido, 0788214, Japan

  • Novartis Investigative Site

    Sapporo, Hokkaido, 0040052, Japan

  • Novartis Investigative Site

    Sapporo, Hokkaido, 0620003, Japan

  • Novartis Investigative Site

    Sapporo, Hokkaido, 065-0027, Japan

  • Novartis Investigative Site

    Amagasaki, Hyōgo, 660-8511, Japan

  • Novartis Investigative Site

    Himeji, Hyōgo, 6708560, Japan

  • Novartis Investigative Site

    Kobe, Hyōgo, 654-0026, Japan

  • Novartis Investigative Site

    Ono, Hyōgo, 675-1327, Japan

  • Novartis Investigative Site

    Takarazuka, Hyōgo, 665-0873, Japan

  • Novartis Investigative Site

    Kamisu, Ibaraki, 314-0146, Japan

  • Novartis Investigative Site

    Koga, Ibaraki, 306-0232, Japan

  • Novartis Investigative Site

    Mito, Ibaraki, 310-0015, Japan

  • Novartis Investigative Site

    Moriya, Ibaraki, 302-0102, Japan

  • Novartis Investigative Site

    Tsukuba, Ibaraki, 3058576, Japan

  • Novartis Investigative Site

    Kagoshima, Kagoshima-ken, 890-8760, Japan

  • Novartis Investigative Site

    Fujisawa, Kanagawa, 252-0802, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 224-8503, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 235-0016, Japan

  • Novartis Investigative Site

    Yokosuka, Kanagawa, 239-8567, Japan

  • Novartis Investigative Site

    Yokosuka, Kanagawa, 240-0101, Japan

  • Novartis Investigative Site

    Yatsushiro, Kumamoto, 866-8533, Japan

  • Novartis Investigative Site

    Kyoto, Kyoto, 602-8566, Japan

  • Novartis Investigative Site

    Kyoto, Kyoto, 612-8555, Japan

  • Novartis Investigative Site

    Kyōtanabe, Kyoto, 610-0334, Japan

  • Novartis Investigative Site

    Tsu, Mie-ken, 514-8507, Japan

  • Novartis Investigative Site

    Nagasaki, Nagasaki, 8508555, Japan

  • Novartis Investigative Site

    Nagasaki, Nagasaki, 852-8055, Japan

  • Novartis Investigative Site

    Ōmura, Nagasaki, 856-8562, Japan

  • Novartis Investigative Site

    Ikoma, Nara, 636-0802, Japan

  • Novartis Investigative Site

    Kashihara, Nara, 634-0045, Japan

  • Novartis Investigative Site

    Tenri, Nara, 632-8552, Japan

  • Novartis Investigative Site

    Nagaoka, Niigata, 940-8621, Japan

  • Novartis Investigative Site

    Ōita, Oita Prefecture, 870-0263, Japan

  • Novartis Investigative Site

    Ōita, Oita Prefecture, 870-1133, Japan

  • Novartis Investigative Site

    Ōita, Oita Prefecture, 879-7761, Japan

  • Novartis Investigative Site

    Kurashiki, Okayama-ken, 7108602, Japan

  • Novartis Investigative Site

    Urasoe, Okinawa, 901-2102, Japan

  • Novartis Investigative Site

    Uruma, Okinawa, 904-2293, Japan

  • Novartis Investigative Site

    Izumisano, Osaka, 5988577, Japan

  • Novartis Investigative Site

    Moriguchi, Osaka, 570-8507, Japan

  • Novartis Investigative Site

    Osaka, Osaka, 5400006, Japan

  • Novartis Investigative Site

    Osaka, Osaka, 543-8922, Japan

  • Novartis Investigative Site

    Takatsuki, Osaka, 569-0852, Japan

  • Novartis Investigative Site

    Takatsuki, Osaka, 569-1121, Japan

  • Novartis Investigative Site

    Takatsuki, Osaka, 5698686, Japan

  • Novartis Investigative Site

    Toyonaka, Osaka, 560-0083, Japan

  • Novartis Investigative Site

    Asaka, Saitama, 3510021, Japan

  • Novartis Investigative Site

    Gyōda, Saitama, 361-0056, Japan

  • Novartis Investigative Site

    Iruma-gun, Saitama, 3500495, Japan

  • Novartis Investigative Site

    Kitamoto, Saitama, 364-8501, Japan

  • Novartis Investigative Site

    Sōka, Saitama, 340-0043, Japan

  • Novartis Investigative Site

    Tokorozawa, Saitama, 359-1142, Japan

  • Novartis Investigative Site

    Nagahama, Shiga, 526-8580, Japan

  • Novartis Investigative Site

    Izunokuni, Shizuoka, 410-2295, Japan

  • Novartis Investigative Site

    Mooka, Tochigi, 321-4306, Japan

  • Novartis Investigative Site

    Hachiōji, Tokyo, 192-0918, Japan

  • Novartis Investigative Site

    Machida, Tokyo, 194-0021, Japan

  • Novartis Investigative Site

    Meguro City, Tokyo, 153-8515, Japan

  • Novartis Investigative Site

    Minato, Tokyo, 106-0031, Japan

  • Novartis Investigative Site

    Nerima-ku, Tokyo, 176-8530, Japan

  • Novartis Investigative Site

    Shinjuku, Tokyo, 160-8488, Japan

  • Novartis Investigative Site

    Shinjuku Ku, Tokyo, 1628666, Japan

  • Novartis Investigative Site

    Sumida City, Tokyo, 130-8575, Japan

  • Novartis Investigative Site

    Toshima-ku, Tokyo, 171-0014, Japan

  • Novartis Investigative Site

    Takaoka, Toyama, 939-1104, Japan

  • Novartis Investigative Site

    Hashimoto, Wakayama, 648-0005, Japan

  • Novartis Investigative Site

    Sakata, Yamagata, 998-8501, Japan

  • Novartis Investigative Site

    Yamagata, Yamagata, 990-9585, Japan

  • Novartis Investigative Site

    Akita, 0108577, Japan

  • Novartis Investigative Site

    Chiba, 261-0024, Japan

  • Novartis Investigative Site

    Fukuoka, 811-0213, Japan

  • Novartis Investigative Site

    Fukushima, 9601295, Japan

  • Novartis Investigative Site

    Himeji, 671-1227, Japan

  • Novartis Investigative Site

    Ishikawa, 9208641, Japan

  • Novartis Investigative Site

    Kagoshima, 892-0853, Japan

  • Novartis Investigative Site

    Kumamoto, 861-4193, Japan

  • Novartis Investigative Site

    Kyoto, 6078062, Japan

  • Novartis Investigative Site

    Nara, 630-8581, Japan

  • Novartis Investigative Site

    Okayama, 7008558, Japan

  • Novartis Investigative Site

    Osaka, 543-8555, Japan

  • Novartis Investigative Site

    Osaka, 5458586, Japan

  • Novartis Investigative Site

    Osaka, 558-8558, Japan

  • Novartis Investigative Site

    Shizuoka, 422-8527, Japan