Triple immunotherapy cocktail shows promise in tough cancers

NCT ID NCT04370704

Completed Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a combination of three immunotherapy drugs (INCMGA00012, INCAGN02385, and INCAGN02390) in 61 people with advanced melanoma or other solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and see if the drugs could shrink tumors. While the approach aims to control the disease, it is not a cure because ongoing treatment or monitoring is typically needed.

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Conditions

The condition(s) this trial relates to.

melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA

Contacts and locations

Locations

Box Hill Hospital

Box Hill, Victoria, 03128, Australia
Cancer Center For Blood Disorders A Division of American Oncology Partners P.A

Bethesda, Maryland, 20817, United States
Carolina Bio Oncology

Huntersville, North Carolina, 28078, United States
Flinders Medical Centre

Bedford Park, South Australia, 05042, Australia
Greenslopes Private Hospital

Brisbane, Queensland, Australia
H Lee Moffitt Cancer Center and Research

Tampa, Florida, 33612, United States
Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
John Theurer Cancer Center, Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Melanoma Institute Australia

Wollstonecraft, New South Wales, 02060, Australia
Nyu Langone Laura and Isaac Perlmutter Cancer Center

New York, New York, 10016, United States
One Clinical Research

Nedlands, Western Australia, 06009, Australia
Penn State Hershey Cancer Institute

Hershey, Pennsylvania, 17033, United States
The Angeles Clinic and Research Institute

Los Angeles, California, 90025, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Miami Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States
University of Washington-Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Washington University

St Louis, Missouri, 63110, United States

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