Can a special diet shape brain development in a rare epilepsy?
NCT ID NCT06054347
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This study looks at how children over age 3 with pyridoxine-dependent epilepsy, a rare genetic condition, develop cognitively over time. Researchers will use a standardized questionnaire called Vineland II to measure adaptive behaviors like communication and daily living skills. The goal is to see if current treatments, especially a lysine-restricted diet, influence long-term neurocognitive outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Vineland II Adaptive Behaviour Scales questionnaire
- What this could lead to
- If successful, this could clarify how treatments like a lysine-restricted diet affect long-term brain development in children with this rare epilepsy.
- What could go wrong
- This is a small observational study, so results may not apply to all patients. It measures development at one point, not long-term change.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHRU Morvan
Brest, 29609, France
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CHU Angers
Angers, 49100, France
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CHU Gui de Chautiac
Montpellier, 34295, France
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CHU Toulouse
Toulouse, 31100, France
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CHU d'Estaing
Clermont-Ferrand, 63003, France
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Centre Hospitalier Saint Nazaire
Saint-Nazaire, 44600, France
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Centre Hospitalier Universitaire de Besançon
Besançon, 25030, France
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Hôpital Bicêtre
Le Kremlin-Bicêtre, 94270, France
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Hôpital Clocheville
Tours, 37000, France
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Hôpital Jeanne de Flandre
Lille, 59037, France
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Hôpital Necker-Enfants malades
Paris, 75749, France
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Hôpital de la Timone-Enfants
Marseille, 13005, France
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