Which mouthpiece best keeps airways open during sleep? a Head-to-Head test
NCT ID NCT06810479
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This study compares two different mandibular advancement devices—oral appliances that hold the jaw forward during sleep—to see which works better for people with mild-to-moderate obstructive sleep apnea. Participants will wear each device for three months, with a two-week break in between, and the order is randomly assigned. The main goal is to see how much each device reduces breathing pauses (apneas and hypopneas) per hour, measured by an overnight home sleep test. The trial also tracks oxygen levels and patient-reported sleepiness and comfort.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Two mandibular advancement devices (oral appliances that reposition the jaw during sleep)
- What this could lead to
- If one device proves more effective, it could point to a better non-invasive option for managing mild-to-moderate sleep apnea.
- What could go wrong
- The trial is small (16 participants) and early, so results may not apply broadly. Devices may cause discomfort or not improve breathing enough.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ziekenhuis Oost-Limburg
Genk, 3600, Belgium
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Other studies related to the condition(s) this trial covers.