New hope for breast cancer survivors: trial tests vaginal treatments for hormone therapy side effects
NCT ID NCT05562518
First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 3 times
Summary
This study tests four different vaginal treatments (estrogen, DHEA, estrogen with probiotics, and a moisturizer) in 160 breast cancer patients who have vaginal atrophy due to hormone therapy. The goal is to see which treatment best relieves symptoms like dryness and pain, and improves quality of life, while monitoring hormone levels for safety. Participants will use the treatments for 12 weeks, and their symptoms and vaginal health will be tracked.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Estrogen, dehydroepiandrosterone (DHEA), probiotics, and moisturizer
- What this could lead to
- If successful, this trial could identify safe and effective local treatments for vaginal atrophy in breast cancer survivors, improving their comfort and quality of life.
- What could go wrong
- This is a phase 4 trial with a moderate size (160 participants). The treatments are already approved for other uses, but their safety and effectiveness in this specific group are still being studied. Results may not apply to all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University Hospital Ghent
Ghent, 9000, Belgium
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