Hope for Alzheimer's agitation: new drug shows promise in major trial

NCT ID NCT05557409

Completed Symptom relief Sponsor: Axsome Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study tested an experimental drug called AXS-05 to see if it can safely reduce agitation in people with Alzheimer's disease. About 408 participants took either the drug or a placebo for several weeks. The goal was to measure changes in agitation using a standard rating scale.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Psychomotor Agitation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGITATION AGITATION IN PATIENTS WITH DEMENTIA OF THE ALZHEIMER'S TYPE ALZHEIMER DISEASE

Contacts and locations

Locations

Clinical Research Site

Peoria, Arizona, 85381, United States
Clinical Research Site

Tempe, Arizona, 85282, United States
Clinical Research Site

Tucson, Arizona, 85710, United States
Clinical Research Site

Canoga Park, California, 91303, United States
Clinical Research Site

Long Beach, California, 90807, United States
Clinical Research Site

Los Alamitos, California, 90720, United States
Clinical Research Site

Walnut Creek, California, 94596, United States
Clinical Research Site

West Covina, California, 91790, United States
Clinical Research Site

Bonita Springs, Florida, 34134, United States
Clinical Research Site

Brandon, Florida, 33511, United States
Clinical Research Site

Green Acres, Florida, 33467, United States
Clinical Research Site

Hialeah, Florida, 33012, United States
Clinical Research Site

Hollywood, Florida, 33024, United States
Clinical Research Site

Kissimmee, Florida, 34741, United States
Clinical Research Site

Miami, Florida, 33126, United States
Clinical Research Site

Miami, Florida, 33135, United States
Clinical Research Site

Miami, Florida, 33145, United States
Clinical Research Site

Miami, Florida, 33155, United States
Clinical Research Site

Miami, Florida, 33165, United States
Clinical Research Site

Miami, Florida, 33173, United States
Clinical Research Site

Miami, Florida, 33175, United States
Clinical Research Site

Miami Gardens, Florida, 33014, United States
Clinical Research Site

Miami Lakes, Florida, 33014, United States
Clinical Research Site

Orlando, Florida, 32807, United States
Clinical Research Site

Pembroke Pines, Florida, 33025, United States
Clinical Research Site

Tampa, Florida, 33614, United States
Clinical Research Site

Tampa, Florida, 33634, United States
Clinical Research Site

Augusta, Georgia, 30912, United States
Clinical Research Site

College Park, Georgia, 30349, United States
Clinical Research Site

Columbus, Georgia, 31909, United States
Clinical Research Site

Wichita, Kansas, 67214, United States
Clinical Research Site

Marrero, Louisiana, 70072, United States
Clinical Research Site

Braintree, Massachusetts, 02184, United States
Clinical Research Site

Flint, Michigan, 48532, United States
Clinical Research Site

Rochester Hills, Michigan, 48307, United States
Clinical Research Site

Troy, Michigan, 48085, United States
Clinical Research Site

Chesterfield, Missouri, 63005, United States
Clinical Research Site

Berlin, New Jersey, 08009, United States
Clinical Research Site

Toms River, New Jersey, 08755, United States
Clinical Research Site

Brooklyn, New York, 11229, United States
Clinical Research Site

New Windsor, New York, 12553, United States
Clinical Research Site

Staten Island, New York, 10314, United States
Clinical Research Site

Woodmere, New York, 11598, United States
Clinical Research Site

Charlotte, North Carolina, 28211, United States
Clinical Research Site

Hickory, North Carolina, 28601, United States
Clinical Research Site

Middleburg Heights, Ohio, 44130, United States
Clinical Research Site

Austin, Texas, 78737, United States
Clinical Research Site

Cypress, Texas, 77429, United States
Clinical Research Site

Mesquite, Texas, 75149, United States
Clinical Research Site

San Antonio, Texas, 78229, United States
Clinical Research Site

Sugarland, Texas, 77478, United States
Clinical Research Site

Rutland, Vermont, 05701, United States
Clinical Research Site

Arlington, Virginia, 22205, United States
Clinical Research Site

Bayamón, Puerto Rico, 00961, Puerto Rico
Clinical Research Site

San Juan, Puerto Rico, 00918, Puerto Rico

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