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Can allergy shots quiet the sneezing and stuffy nose caused by dust mites?

NCT ID NCT06920771

Completed Disease control Sponsor: HAL Allergy Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests whether a series of allergy shots, called PURETHAL Mites, can reduce symptoms like sneezing, runny nose, and congestion in adults with moderate to severe house dust mite allergies, with or without asthma. Participants receive either the active treatment or a placebo over about a year, and their symptom and medication scores are compared. The goal is to see if this immunotherapy can provide meaningful relief and improve quality of life for people whose allergies are triggered by dust mites.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
PURETHAL Mites mixture, a modified house dust mite extract given as allergy shots
What this could lead to
If successful, this could offer a disease-modifying treatment that reduces allergy symptoms and medication use for people with house dust mite allergies.
What could go wrong
This is a Phase 3 trial, but results are not guaranteed. The treatment may not outperform placebo, and allergy shots can cause local reactions or, rarely, more serious allergic responses.

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Conditions

The condition(s) this trial relates to.

allergic disease allergic rhinitis Dust Mite Allergy perennial allergic rhinitis rhinitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HOUSE DUST MITE ALLERGY HOUSE DUST MITE RHINITIS

Contacts and locations

Locations

  • ALERGOTEST s.c. Specjalistyczne Centrum Medyczne

    Lublin, Poland

  • Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. z o. o.

    Tarnów, Poland

  • All-Med - Specjalistyczna Opieka Medyczna - Medyczny Instytut Badawczy

    Wroclaw, Poland

  • Allergo GmbH - Prüfzentrum Schorndorf

    Schorndorf, Germany

  • BAG Prof. G. Hoheisel/Dr. A. Bonitz Praxis für Pneumologie und Allergologie - Studienzentrum

    Leipzig, Germany

  • Ballenberger, Freytag, Wenisch -Institut für klinische Forschung GmbH

    Neu-Isenburg, Germany

  • CD8 clinic

    Kaunas, Lithuania

  • CM Szpital Św. Rodziny

    Lodz, Poland

  • Centrum Alergologii

    Poznan, Poland

  • Centrum Alergologii Irmed Irena Wojciechowska

    Warsaw, Poland

  • Centrum Alergoologii Specjalistyczna Przychodnia Alergologiczna

    Lublin, Poland

  • Centrum Diagnostyczno-Terapeutyczne Medicus Sp. z o.o.

    Lubin, Poland

  • Centrum Medyczne Angelius Provita

    Katowice, Poland

  • Centrum Medyczne KERmed

    Bydgoszcz, Poland

  • Centrum Nowoczesnych Terapii "Dobry Lekarz" Sp. z o.o.

    Krakow, Poland

  • Clinica Vitae Spółka z o. o.

    Gdansk, Poland

  • Clinmedica Research sp. z o.o.

    Lodz, Poland

  • DCC Convex

    Sofia, Bulgaria

  • Diagnostic-Consulativ Senter Ascendent

    Sofia, Bulgaria

  • ETG Warszawa

    Warsaw, Poland

  • Emovis GmbH

    Berlin, Germany

  • Gabinet Lekarski Bożena Kubicka-Kozik

    Tomaszów Mazowiecki, Poland

  • HNO Praxis Dr. Uta Thieme

    Duisburg, Germany

  • HNO Research GmbH

    Itzehoe, Germany

  • HNO-Facharztpraxis Alte Post

    Göttingen, Germany

  • HNO-Praxis Dr. Udo Schäfer

    Dresden, Germany

  • Hospital Schleswig-Holstein. Klinik für Dermatologie, Venerologie und Allergologie.

    Kiel, 24105, Germany

  • IP Clinic Sp. z o. o.

    Lodz, Poland

  • Indywidualna Specjalistyczna Praktyka Lekarska Elżbieta Matusz

    Gryfice, Poland

  • Indywidualna Specjalistyczna Praktyka Lekarska Jan Zdanowski Specjalista Alergolog

    Koszalin, Poland

  • Inovatyvios alergologijos centras

    Vilnius, Lithuania

  • JSC Center for Diagnosis and Treatment of Allergic Diseases

    Vilnius, Lithuania

  • JSC Family Doctor

    Vilnius, Lithuania

  • JSC Inlita

    Vilnius, Lithuania

  • JSC Verkiu clinic

    Vilnius, Lithuania

  • KliFOs - Klinische Forschung Osnabrück

    Osnabrück, Germany

  • Klinikum Stuttgart - Krankenhaus Bad Cannstatt

    Stuttgart, Germany

  • Krakowskie Centrum Medyczne Sp. z o.o - FutureMeds Kraków

    Krakow, Poland

  • LOR Clinic

    Riga, Latvia

  • Lithuanian University of Health Sciences Kauno klinikos

    Kaunas, Lithuania

  • Małopolskie Centrum Alergologii sp z o.o.

    Krakow, Poland

  • Medical Center Prolet EOOD

    Rousse, Bulgaria

  • Medical Center Smolyan

    Smolyan, Bulgaria

  • Medical University of Lodz

    Lodz, Poland

  • Medizentrum Essen-Borbeck

    Essen, Germany

  • NSZOZ Puls Med

    Skarżysko-Kamienna, Poland

  • NZOZ Alergo-Med

    Poznan, Poland

  • NZOZ Centrum Usług Medycznych "PROXIMUM" Sp. z o. o.

    Wroclaw, Poland

  • NZOZ Homeo Medicus Poradnia Alergologiczna

    Bialystok, Poland

  • POLIMEDICA CENTRUM BADAŃ, PROFILAKTYKI I LECZENIA Sp. z o.o. - POLIMEDICA PTG

    Warsaw, Poland

  • PZU Zdrowie Centra Medyczne Kielce

    Kielce, Poland

  • Pneumologisches Forschungsinstitut Hohegeest GbR

    Geesthacht, Germany

  • Poradnie Specjalistyczne Alergologia Plus - Justyna Rakowicz

    Poznan, Poland

  • Pratia - Ośrodek Badań Klinicznych

    Częstochowa, Poland

  • Praxis Dr. Bohn

    Mittweida, Germany

  • Praxis Dr. Elke Decot

    Dreieich, Germany

  • Praxis Dr. Ginko

    Bonn, Germany

  • Pro Life Medica Sp. z o.o.

    Lublin, Poland

  • Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny Anna Płoszczuk

    Bialystok, Poland

  • Specjalistyczna Praktyka Lekarska AlerMedica

    Bialystok, Poland

  • Specjalistyczna Praktyka Lekarska dr n.med. Joanna Orlicz-Widawska

    Katowice, Poland

  • Studienzentrum Dr.Laßmann

    Saalfeld, Germany

  • Studienzentrum Dr.Schlenska

    Peine, Germany

  • Studienzentrum MOL BAG Dres. E.Hippke & S. Runge

    Neuenhagen, Germany

  • The Center of Investigation in Treatment of Allergyc Diseases

    Riga, Latvia

  • UMBAL Kaspela

    Plovdiv, Bulgaria

  • University Hospital Alexandrovska

    Sofia, Bulgaria

  • Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie

    Lublin, Poland

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