Brain scans could reveal which MS drugs fight mental exhaustion
NCT ID NCT04448977
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This study investigates whether disease-modifying medications for relapsing-remitting multiple sclerosis (RRMS) can reduce cognitive fatigue—the tiredness that follows intense mental effort. Researchers will use functional MRI to measure brain activation in people starting either Ocrevus or Copaxone, comparing them to healthy volunteers. The goal is to identify a brain-based biomarker that tracks fatigue, which could help personalize MS treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ocrevus (ocrelizumab) and Copaxone (glatiramer acetate)
- What this could lead to
- If successful, this could lead to a brain-imaging biomarker that helps doctors choose MS treatments that better manage cognitive fatigue.
- What could go wrong
- This is a small, early-stage study (24 participants) that measures brain activity, not long-term outcomes. Results may not apply to all MS patients, and the medications may have side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kessler Foundation
West Orange, New Jersey, 07052, United States
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