Brain scans may reveal how MS drug affects mental fatigue
NCT ID NCT04565431
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This study explores whether the medication Tysabri can reduce cognitive fatigue—the tiredness that comes after intense mental effort—in people with relapsing-remitting multiple sclerosis (RRMS). Researchers will compare brain activity, measured with functional MRI, between RRMS patients starting Tysabri and healthy volunteers matched by age, gender, and education. The goal is to see if changes in brain activation correlate with fatigue levels, potentially identifying a biomarker for cognitive fatigue in MS.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tysabri (natalizumab), a drug used to treat multiple sclerosis
- What this could lead to
- If successful, this could point toward a way to measure and treat cognitive fatigue in multiple sclerosis, improving daily life for patients.
- What could go wrong
- This is a very small early-stage study (7 participants), so results may not apply broadly. It focuses on brain imaging markers rather than direct patient outcomes, and the drug may have side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kessler Foundation
West Orange, New Jersey, 07052, United States
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