New pill could slow MS disability in major trial

NCT ID NCT07299019

Recruiting now Disease control Sponsor: Zenas BioPharma (USA), LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 17 times

Summary

This Phase 3 trial tests an oral drug called orelabrutinib against a placebo in about 990 people with non-active secondary progressive multiple sclerosis (MS). The goal is to see if the drug can delay worsening disability over 24 to 60 months. Participants are randomly assigned to receive either the drug or a placebo, and neither they nor their doctors will know which they are getting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Orelabrutinib (a drug taken orally that targets a protein called BTK to potentially slow disability progression)
What this could lead to: If it works, this could provide a new treatment option to slow disability progression in people with non-active secondary progressive multiple sclerosis.
What could go wrong: This is a large Phase 3 trial, but it is still experimental. The drug may not prove effective in slowing disability, and side effects are possible. Results will take years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis secondary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS

Contacts and locations

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Study contacts

Contact

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Contact

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Locations

Aqualane Clinical Research
RECRUITING

Naples, Florida, 34105, United States
Arizona Neuroscience Research, LLC
RECRUITING

Phoenix, Arizona, 85032, United States
Boston Clinical Trials
WITHDRAWN

Boston, Massachusetts, 02131, United States
EUROMEDIS Osrodek Badan Klinicznych
RECRUITING

Szczecin, 70-111, Poland
Fullerton Neurology and Headache Center
RECRUITING

Fullerton, California, 92835, United States
Galen Clinic
RECRUITING

Lublin, 20-064, Poland
Harbor-UCLA Medical Center - The Lundquist Institute (Los Angeles Biomedical Research Institute (LA BioMed))
RECRUITING

Torrance, California, 90502-2006, United States
Hospital of Lithuanian University of Health Sciences
RECRUITING

Kaunas, Kauno, 50161, Lithuania
Josephson Wallack Munshower Neurology, Pc Suite 225
RECRUITING

Indianapolis, Indiana, 46256, United States
KC Research Center, PA Neurology Research Dept
RECRUITING

Roeland Park, Kansas, 66205, United States
Lone Star Neurology
RECRUITING

San Antonio, Texas, 78258, United States
MA-LEK Clinical Sp. z o.o.
RECRUITING

Katowice, 40-571, Poland
MS and Neuromuscular Center of Excellence
RECRUITING

Clearwater, Florida, 33761, United States
Malva Trials
RECRUITING

Lublin, 20-601, Poland
NEUROHK, s.r.o.
RECRUITING

Choceň, 56501, Czechia
NZOZ Novo Med
RECRUITING

Katowice, Silesian Voivodeship, 40-584, Poland
Neurology Associates
RECRUITING

Maitland, Florida, 32751, United States
Nmedis sp. z o.o.
RECRUITING

Rzeszów, Rzeszów, 35-323, Poland
Nova Clinical Research, LLC
RECRUITING

Bradenton, Florida, 34209, United States
OMRF Multiple Sclerosis Center of Excellence
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Perseverance Research Center, LLC (PRC)
RECRUITING

Scottsdale, Arizona, 85253, United States
Premier Neurology
RECRUITING

Greenville, South Carolina, 29605, United States
Profound Research LLC at Oakland Neurology Center
RECRUITING

Rochester Hills, Michigan, 48307, United States
Regina Berkovich MD, PhD Inc
RECRUITING

West Hollywood, California, 90048, United States
SFM Clinical Research, LLC
RECRUITING

Boca Raton, Florida, 33487, United States
Texas Institute for Neurological Disorders - Sherman
RECRUITING

Sherman, Texas, 75092, United States
The Boster Center for Multiple Sclerosis
RECRUITING

Columbus, Ohio, 43235, United States
Twoja Przychodnia Centrum Medyczne Nowa Sól
RECRUITING

Nowa Sól, Lubusz Voivodeship, 67-100, Poland
University Clinical Centre of Kragujevac
RECRUITING

Kragujevac, 3400, Serbia
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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