New pill shows promise against tough blood cancers

NCT ID NCT04728893

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 5 times

Summary

This phase 2 study tests an oral drug called nemtabrutinib in about 490 people with blood cancers like chronic lymphocytic leukemia, non-Hodgkin lymphoma, and Waldenstrom's macroglobulinemia. The goal is to see if the drug can shrink tumors and control the cancer, while also checking for side effects. Participants take a tablet once a day, and the study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nemtabrutinib (also called MK-1026 or ARQ 531), an oral tablet
What this could lead to: If successful, this could provide a new oral treatment option for people with certain blood cancers, helping to shrink tumors and control the disease.
What could go wrong: This is an early-phase (Phase 2) study, so the drug may not work as hoped or could cause serious side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia chronic lymphocytic leukemia/small lymphocytic lymphoma follicular lymphoma hematopoietic and lymphoid system neoplasm Leukemia, B-Cell mantle cell lymphoma marginal zone lymphoma non-Hodgkin lymphoma Richter transformation Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKAEMIA HEMATOLOGIC MALIGNANCIES NON-HODGKINS LYMPHOMA WALDENSTROMS MACROGLOBULINAEMIA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

A.O. Universitaria Policlinico S. Orsola-Malpighi ( Site 1400)
RECRUITING

Bologna, 40138, Italy
ASST Spedali Civili di Brescia ( Site 1408)
RECRUITING

Brescia, 25123, Italy
Aalborg Universitetshospital ( Site 0703)
RECRUITING

Aalborg, North Denmark, 9000, Denmark
Aarhus University Hospital ( Site 0702)
COMPLETED

Aarhus N, Central Jutland, 8200, Denmark
Anhui Provincial Hospital ( Site 2808)
ACTIVE_NOT_RECRUITING

Hefei, Anhui, 230071, China
Ankara Universitesi Tip Fakultesi Cebeci Hastanesi ( Site 2400)
RECRUITING

Ankara, 06590, Turkey (Türkiye)
Arthur J.E. Child Comprehensive Cancer Centre ( Site 0401)
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Astera Cancer Care ( Site 2732)
RECRUITING

East Brunswick, New Jersey, 08816, United States
BP - A Beneficencia Portuguesa de São Paulo ( Site 0302)
ACTIVE_NOT_RECRUITING

São Paulo, 01321-001, Brazil
Beaumont Hospital ( Site 2900)
RECRUITING

Dublin, Dublin 9, Ireland
Box Hill Hospital ( Site 0203)
RECRUITING

Box Hill, Victoria, 3128, Australia
Bristol Haematology and Oncology Centre ( Site 2610)
RECRUITING

Bristol, Bristol, City of, BS2 8ED, United Kingdom
CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 2005)
RECRUITING

A Coruña, La Coruna, 15006, Spain
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0403)
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Centre Hospitalier Lyon-Sud ( Site 0804)
RECRUITING

Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet ( Site 0810)
RECRUITING

Nice, Alpes-Maritimes, 06202, France
Centre Hospitalier de Versailles ( Site 0809)
COMPLETED

Le Chesnay, Yvelines, 78150, France
Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0103)
RECRUITING

Buenos Aires, Buenos Aires F.D., C1431FWO, Argentina
Centrul de Diagnostic si Tratament Oncologic Brasov ( Site 1802)
RECRUITING

Brasov, 500052, Romania
Chaim Sheba Medical Center ( Site 1302)
RECRUITING

Ramat Gan, 5262001, Israel
Colorado Blood Cancer Institute ( Site 2726)
RECRUITING

Denver, Colorado, 80218, United States
Communal non-profit enterprise "Regional clinical hospital o-Hematology Department ( Site 2510)
COMPLETED

Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76008, Ukraine
Debreceni Egyetem Klinikai Kozpont ( Site 1201)
RECRUITING

Debrecen, Hajdú-Bihar, 4032, Hungary
Dokuz Eylül Üniversitesi-Hematology ( Site 2402)
ACTIVE_NOT_RECRUITING

Izmir, 35340, Turkey (Türkiye)
FUNDALEU ( Site 0104)
RECRUITING

Caba, C1114AAN, Argentina
Fakultni nemocnice Hradec Kralove ( Site 0601)
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0600)
RECRUITING

Brno, Brno-mesto, 625 00, Czechia
Fondazione IRCCS Policlinico San Matteo ( Site 1407)
RECRUITING

Pavia, 27100, Italy
Fudan University Shanghai Cancer Center ( Site 2801)
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0110)
COMPLETED

Mendoza, M5500AYB, Argentina
Fundacion Estudios Clinicos ( Site 0112)
RECRUITING

Rosario, Santa Fe Province, S2000DEJ, Argentina
GenesisCare - Cambridge ( Site 2611)
RECRUITING

Newmarket, Suffolk, CB8 7XN, United Kingdom
GenesisCare - Oxford ( Site 2607)
RECRUITING

Oxford, Oxfordshire, OX4 6LB, United Kingdom
GenesisCare - Windsor ( Site 2608)
RECRUITING

Windsor, England, SL4 3HD, United Kingdom
Guangxi Medical University Cancer Hospital ( Site 2814)
RECRUITING

Nanning, Guangxi, 530028, China
Ha Emek Medical Center ( Site 1305)
RECRUITING

Afula, 1834111, Israel
Hadassah Ein Karem Jerusalem ( Site 1300)
RECRUITING

Jerusalem, 9112001, Israel
Henan Cancer Hospital-hematology department ( Site 2802)
RECRUITING

Zhengzhou, Henan, 450008, China
Highlands Oncology Group ( Site 2728)
RECRUITING

Springdale, Arkansas, 72762, United States
Hopital Saint Louis ( Site 0805)
RECRUITING

Paris, 75010, France
Hospital Aleman ( Site 0102)
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1118AAT, Argentina
Hospital General Universitario de Alicante ( Site 2007)
RECRUITING

Alicante, 03010, Spain
Hospital Paulistano - Amil Clinical Research ( Site 0311)
RECRUITING

São Paulo, 01321-001, Brazil
Hospital Privado Universitario de Córdoba ( Site 0107)
RECRUITING

Córdoba, X5016KEH, Argentina
Hospital Puerta de Hierro ( Site 2009)
RECRUITING

Madrid, 28222, Spain
Hospital Universitari Vall d'Hebron ( Site 2001)
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre ( Site 2003)
RECRUITING

Madrid, 28041, Spain
Hospital Universitario de Salamanca ( Site 2002)
RECRUITING

Salamanca, Castille and León, 37007, Spain
Hospital das Clinicas FMUSP-Pesquisa Clínica Hematologia ( Site 0303)
RECRUITING

São Paulo, São Paulo, 05403-000, Brazil
Huashan Hospital, Fudan University ( Site 2821)
RECRUITING

Shanghai, Shanghai Municipality, 200040, China
Hunan Cancer Hospital ( Site 2822)
RECRUITING

Changsha, Hunan, 410013, China
IRCCS - Arcispedale Santa Maria Nuova ( Site 1405)
RECRUITING

Reggio Emilia, 42123, Italy
IRCCS Ospedale San Raffaele ( Site 1402)
RECRUITING

Milan, 20132, Italy
Inselspital Bern ( Site 2303)
RECRUITING

Bern, Canton of Bern, 3010, Switzerland
Instit. of Blood Transfusion Medicine of the National Academy ( Site 2506)
RECRUITING

Lviv, Lviv Oblast, 79044, Ukraine
Institut Paoli-Calmettes ( Site 0803)
RECRUITING

Marseille, Bouches-du-Rhone, 13009, France
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Unio ( Site 2800)
RECRUITING

Tianjin, Tianjin Municipality, 301617, China
Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 2000)
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0300)
RECRUITING

Rio de Janeiro, 20231-050, Brazil
Institutul Regional de Oncologie Iasi ( Site 1801)
RECRUITING

Iași, 700483, Romania
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1403)
RECRUITING

Naples, 80131, Italy
Istituto Oncologica della Svizzera Italiana (IOSI) ( Site 2302)
RECRUITING

Bellinzona, Canton Ticino, 6500, Switzerland
Istituto Tumori Giovanni Paolo II ( Site 1409)
ACTIVE_NOT_RECRUITING

Bari, 70124, Italy
Jiangsu Province Hospital ( Site 2823)
RECRUITING

Nanjing, Jiangsu, 210029, China
John Theurer Cancer Center at Hackensack University Medical Center ( Site 2704)
RECRUITING

Hackensack, New Jersey, 07601, United States
Kaplan Medical Center ( Site 1304)
RECRUITING

Rehovot, 76100, Israel
Liuzhou People's Hospital ( Site 2817)
RECRUITING

Liuzhou, Guangxi, 545006, China
Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site 2724)
COMPLETED

Torrance, California, 90502, United States
MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2509)
ACTIVE_NOT_RECRUITING

Cherkassy, Cherkasy Oblast, 18009, Ukraine
Mayo Clinic - Rochester ( Site 2706)
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
Medical Oncology Associates (Summit Cancer Centers) ( Site 2710)
RECRUITING

Spokane, Washington, 99208, United States
Mega Medipol-Hematology ( Site 2406)
ACTIVE_NOT_RECRUITING

Stanbul, Istanbul, 34214, Turkey (Türkiye)
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site 1608)
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland
National Cancer Institute ( Site 2507)
RECRUITING

Kyiv, 03022, Ukraine
Nepean Hospital-Nepean Cancer Care Centre ( Site 0204)
COMPLETED

Sydney, New South Wales, 2747, Australia
Nottingham University Hospitals NHS Trust. City Hospital Campus ( Site 2601)
RECRUITING

Nottingham, England, NG5 1PF, United Kingdom
Odense University Hospital ( Site 0705)
COMPLETED

Odense C, Region Syddanmark, 5000, Denmark
Orszagos Onkologiai Intezet ( Site 1200)
RECRUITING

Budapest, 1122, Hungary
Ovidius Clinical Hospital ( Site 1804)
COMPLETED

Ovidiu, Constanța County, 905900, Romania
Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar ( Site 1202)
RECRUITING

Pécs, Baranya, 7624, Hungary
Peking University Third Hospital-Hematology ( Site 2827)
RECRUITING

Beijing, Beijing Municipality, 100191, China
Policlinico Umberto I ( Site 1404)
COMPLETED

Roma, 00161, Italy
Pratia MCM Krakow ( Site 1601)
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-727, Poland
Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0406)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Rambam Medical Center ( Site 1301)
RECRUITING

Haifa, 3109601, Israel
Samsung Medical Center ( Site 2200)
RECRUITING

Seoul, 06351, South Korea
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 2708)
COMPLETED

Fargo, North Dakota, 58102, United States
Sarah Cannon Research Institute UK ( Site 2612)
RECRUITING

London, London, City of, W1G 6AD, United Kingdom
Severance Hospital Yonsei University Health System ( Site 2201)
RECRUITING

Seoul, 03722, South Korea
Sir Charles Gairdner Hospital ( Site 0200)
RECRUITING

Nedlands, Western Australia, 6009, Australia
Sisli Florence Nightingale Hastanesi ( Site 2407)
RECRUITING

Istanbul, 34381, Turkey (Türkiye)
Sjaellands Universitetshospital Roskilde ( Site 0701)
RECRUITING

Roskilde, Region Sjælland, 4000, Denmark
Soroka Medical Center ( Site 1307)
RECRUITING

Beersheba, 8457108, Israel
Sourasky Medical Center ( Site 1303)
RECRUITING

Tel Aviv, 6423906, Israel
Spitalul Clinic Colțea ( Site 1805)
RECRUITING

Bucharest, Bucharest, 030171, Romania
St. Marien-Krankenhaus Siegen ( Site 0914)
COMPLETED

Siegen, North Rhine-Westphalia, 57072, Germany
Sun Yat-sen University Cancer Center-Internal Medicine ( Site 2824)
ACTIVE_NOT_RECRUITING

Guangzhou, Guangdong, 510060, China
Szabolcs Szatmár Bereg Vármegyei Oktatókórház ( Site 1206)
RECRUITING

Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary
Szpital Wojewódzki w Opolu-Hematology Department ( Site 1607)
COMPLETED

Opole, Opole Voivodeship, 45-061, Poland
Szpitale Pomorskie Sp. z o.o. ( Site 1600)
COMPLETED

Gdynia, Pomeranian Voivodeship, 81-519, Poland
The Affiliated Hospital of Xuzhou Medical College ( Site 2818)
ACTIVE_NOT_RECRUITING

Xuzhou, Jiangsu, 221000, China
The Christie NHS Foundation Trust ( Site 2602)
RECRUITING

Manchester, M20 4BX, United Kingdom
The First Affiliated Hospital of Nanchang University ( Site 2815)
RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital, Zhejiang University ( Site 2826)
RECRUITING

Hangzhou, Zhejiang, 310002, China
The First Hospital of Jilin University-Hematology ( Site 2803)
RECRUITING

Changchun, Jilin, 130021, China
The Ottawa Hospital ( Site 0404)
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The Royal Marsden NHS Foundation Trust. ( Site 2606)
RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
The Second Affiliated Hospital of Chongqing Medical University ( Site 2825)
ACTIVE_NOT_RECRUITING

Chongqing, Chongqing Municipality, 400072, China
The Second Xiangya Hospital of Central South University ( Site 2820)
RECRUITING

Changsha, Hunan, 410011, China
The University of Louisville, James Graham Brown Cancer Center ( Site 2729)
COMPLETED

Louisville, Kentucky, 40202, United States
UT Southwestern-Harold C. Simmons Cancer Center ( Site 2730)
RECRUITING

Dallas, Texas, 75390, United States
Universitaetsklinikum Carl Gustav Carus ( Site 0902)
RECRUITING

Dresden, Saxony, 01307, Germany
Universitaetsklinikum Koeln ( Site 0901)
RECRUITING

Cologne, North Rhine-Westphalia, 50937, Germany
Universitaetsklinikum Ulm. ( Site 0906)
RECRUITING

Ulm, Baden-Wurttemberg, 89081, Germany
University Hospital Limerick ( Site 2903)
RECRUITING

Limerick, V94 F858, Ireland
University of California San Diego Moores Cancer Center ( Site 2717)
RECRUITING

La Jolla, California, 92093-0698, United States
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu ( Site 1606)
ACTIVE_NOT_RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-367, Poland
VKV Amerikan Hastanesi ( Site 2403)
COMPLETED

Istanbul, 34365, Turkey (Türkiye)
West China Hospital Sichuan University ( Site 2810)
RECRUITING

Chengdu, Sichuan, 610041, China
Wuhan Union Hospital ( Site 2816)
RECRUITING

Wuhan, Hubei, 430022, China

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