New pill could ease iron overload for thousands with genetic disorder

NCT ID NCT07332091

Recruiting now Disease control Sponsor: CSL Behring Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 04, 2026 · Updated 5 times

Summary

This phase 2 trial tests an experimental drug called vamifeport in 84 adults with HFE-related hereditary hemochromatosis, a genetic condition causing iron buildup. The drug aims to reduce liver iron levels, potentially offering an alternative to regular blood removal. Participants take vamifeport or a placebo daily for several months, with MRI scans tracking changes in liver iron.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vamifeport
What this could lead to: If successful, vamifeport could offer a new oral treatment to control iron overload in hereditary hemochromatosis, potentially reducing the need for regular blood removal (phlebotomy).
What could go wrong: This is an early phase 2 proof-of-concept study with only 84 participants. It may fail to show significant reduction in liver iron, and long-term safety and efficacy are not yet established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hemochromatosis type 1 hereditary hemochromatosis Iron Overload

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HOMEOSTATIC IRON REGULATOR GENE-RELATED HEREDITARY HEMOCHROMATOSIS

Contacts and locations

Locations

AORN Cardarelli
NOT_YET_RECRUITING

Naples, Italy
ASL Brindisi - Presidio Ospedaliero Di Summa - Perrino
NOT_YET_RECRUITING

Brindisi, Italy
Aarhus University Hospital
NOT_YET_RECRUITING

Aarhus, Denmark
Althaia Foundation. Hospital Sant Joan de Deu de Manresa
RECRUITING

Manresa, Spain
American Oncology Partners, PA dba The Center for Cancer and Blood Disorders
RECRUITING

Bethesda, Maryland, 20817, United States
Aotearoa Clinical Trials Trust- Middlemore Hospital
RECRUITING

Auckland, 2025, New Zealand
Aphp Avicenne
NOT_YET_RECRUITING

Bobigny, France
Aspirus St. Luke's Clinic - Duluth - Oncology & Hematology
RECRUITING

Duluth, Minnesota, 55805, United States
Auckland City Hospital
NOT_YET_RECRUITING

Auckland, 1023, New Zealand
Banner MD Anderson
NOT_YET_RECRUITING

Gilbert, Arizona, 85234-2165, United States
Beaumont Hospital
NOT_YET_RECRUITING

Dublin, Ireland
Bispebjerg Hospital
NOT_YET_RECRUITING

Copenhagen, Denmark
Bistrita County Emergency Clinical Hospital
RECRUITING

Bistriţa, Romania
CHU Toulouse
RECRUITING

Toulouse, France
CHU UCL Namur - Site Godinne
NOT_YET_RECRUITING

Yvoir, Belgium
CHU de Bordeaux - Hôpital Haut Leveque
RECRUITING

Pessac, France
CHU de Montpellier- Hôpital Saint Eloi
RECRUITING

Montpellier, France
CRMR Maladies du Globule Rouge, Hôpital de la Timone
RECRUITING

Marseille, France
Cancer Care Associates of York
NOT_YET_RECRUITING

York, Pennsylvania, 17403-5060, United States
Centre Hospitalier Lyon Sud/Hospices Civils de Lyon
RECRUITING

Pierre-Bénite, France
Centre Hospitalier Universitaire Vaudois
NOT_YET_RECRUITING

Lausanne, Switzerland
Centre Hospitalier Universitaire de Liège (CHU de Liège)
NOT_YET_RECRUITING

Liège, Belgium
Centre Hospitalier de Saint Brieuc
RECRUITING

Saint-Brieuc, France
Chu Dupuytren
NOT_YET_RECRUITING

Limoges, France
Chu Rennes
RECRUITING

Rennes, France
Coltea Clinical Hospital
NOT_YET_RECRUITING

Bucharest, Romania
Connolly Hospital Blanchardstown
NOT_YET_RECRUITING

Dublin, Ireland
Copenhagen University Hospital - Hvidovre
NOT_YET_RECRUITING

Hvidovre, Denmark
Cork University Hospital
NOT_YET_RECRUITING

Cork, Ireland
Derriford Hospital
RECRUITING

Plymouth, United Kingdom
Duke University Medical Center (Duke South Clinics) -40 Duke Medicine Cir
RECRUITING

Durham, North Carolina, 27710-4000, United States
EUGASTRO GmbH
RECRUITING

Leipzig, Germany
Epatocentro Ticino
RECRUITING

Lugano, Switzerland
Fakultni nemocnice Ostrava
NOT_YET_RECRUITING

Ostrava, Czechia
Fakultní Nemocnice Brno
NOT_YET_RECRUITING

Brno, Czechia
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, Italy
Fondazione IRCCS San Gerardo dei Tintori
NOT_YET_RECRUITING

Monza, Italy
GHRMSA
NOT_YET_RECRUITING

Mulhouse, France
Gallipoli Medical Research
NOT_YET_RECRUITING

Chandler, Australia
Ghent University Hospital
NOT_YET_RECRUITING

Ghent, Belgium
Green Leaf Clinical Trials
RECRUITING

Jacksonville, Florida, 32258, United States
HUGC Doctor Negrin
RECRUITING

LAS Palmas de GC, Spain
Hightower Clinical - Oklahoma Cancer Center
RECRUITING

Oklahoma City, Oklahoma, 73174, United States
Hospital Clinic Barcelona
RECRUITING

Barcelona, Spain
Hospital Universitari Germans Trias i Pujol
NOT_YET_RECRUITING

Badalona, Spain
Hospital Universitario La Paz
NOT_YET_RECRUITING

Madrid, Spain
Hospital Universitario Puerta de Hierro - Majadahonda
NOT_YET_RECRUITING

Majadahonda, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, Spain
Hunterdon Hematology Oncology, LLC
NOT_YET_RECRUITING

Flemington, New Jersey, 08822, United States
Hôpital Paul Brousse
RECRUITING

Villejuif, France
Indiana University Health University Hospital
RECRUITING

Indianapolis, Indiana, 46202-5149, United States
Infinity Clinical Trials
NOT_YET_RECRUITING

San Diego, California, 92108, United States
Institut Klinicke a Experimentalni Mediciny
NOT_YET_RECRUITING

Prague, Czechia
Instytut Hematologii i Transfuzjologii
NOT_YET_RECRUITING

Warsaw, Poland
Intermountain Medical Center
NOT_YET_RECRUITING

Murray, Utah, 84107, United States
James M. Stockman Cancer Institute
RECRUITING

Frederick, Maryland, 21702-4337, United States
John Radcliffe Hospital - Oxford University Hospitals NHS
NOT_YET_RECRUITING

Oxford, United Kingdom
Johns Hopkins University School of Medicine
NOT_YET_RECRUITING

Baltimore, Maryland, 21205, United States
King's College Hospital
NOT_YET_RECRUITING

London, United Kingdom
L'Institute Oncologique Prof. Dr. Ion Chiricuta (IOCN)
RECRUITING

Cluj-Napoca, Romania
Libin Cardiovascular Institute University of Calgary
NOT_YET_RECRUITING

Calgary, Canada
MVZ für Innere Medizin Weinheim
RECRUITING

Weinheim, Germany
Maastricht UMC
NOT_YET_RECRUITING

Maastricht, Netherlands
McMaster University-St. Josephs Healthcare Hamilton
NOT_YET_RECRUITING

Hamilton, Canada
Medical Oncology Associates of San Diego
NOT_YET_RECRUITING

San Diego, California, 92123, United States
Medical University Vienna
NOT_YET_RECRUITING

Vienna, Austria
Medical University of Innsbruck
NOT_YET_RECRUITING

Innsbruck, Austria
Monash Medical Centre
NOT_YET_RECRUITING

Clayton, Australia
Norfolk and Norwich University Hospital
RECRUITING

Norwich, United Kingdom
Nottingham University Hospitals City Campus
RECRUITING

Nottingham, United Kingdom
Ochsner Medical Complex - High Grove
RECRUITING

Baton Rouge, Louisiana, 70836, United States
Ordensklinikum Linz - Barmherzige Schwestern
NOT_YET_RECRUITING

Linz, Austria
Prof. Dr.Octavian Fodor Regional Institute of Gastroenterology-Hepatology
NOT_YET_RECRUITING

Cluj-Napoca, Romania
Radboud UMC
RECRUITING

Nijmegen, Netherlands
Royal Brisbane and Women's Hospital
NOT_YET_RECRUITING

Brisbane, Australia
Royal Liverpool University Hospital
RECRUITING

Liverpool, United Kingdom
Royal Victoria Hospital
NOT_YET_RECRUITING

Belfast, United Kingdom
South Warwickshire University Foundation Trust
NOT_YET_RECRUITING

Warwick, United Kingdom
Specjalistyczny Szpital im. Alfreda Sokolowskiego
NOT_YET_RECRUITING

Wałbrzych, Poland
Spitalul Clinic de Urgenta Prof Dr Agrippa Ionescu-Balotesti
RECRUITING

Baloteşti, Romania
St Thomas Hospital
NOT_YET_RECRUITING

London, United Kingdom
Trials West
RECRUITING

Perth, Australia
UZ Brussel
NOT_YET_RECRUITING

Jette, Belgium
Universitair Ziekenhuis Antwerpen (UZA)
NOT_YET_RECRUITING

Edegem, Belgium
University Hospital Hairmyres-PPDS
NOT_YET_RECRUITING

Glasgow, Glasgow City Region, SE5 9RS, United Kingdom
University Hospital Heidelberg
RECRUITING

Heidelberg, Germany
University Hospital Inselspital Bern
NOT_YET_RECRUITING

Bern, Switzerland
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, United Kingdom
University Hospital of Modena
NOT_YET_RECRUITING

Modena, Italy
University Hospitals Bristol and Weston NHS trust, Bristol Haematology and Oncology Centre
RECRUITING

Bristol, United Kingdom
University of Manitoba
NOT_YET_RECRUITING

Winnipeg, Canada
University of Michigan Health System (UMHS)
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27517-7518, United States
University of Verona - Azienda Ospedaliera Universitaria Integrata Verona
RECRUITING

Verona, Italy
Universitätsklinikum Freiburg
NOT_YET_RECRUITING

Freiburg im Breisgau, Germany
Velocity Clinical Research-Seattle
RECRUITING

Seattle, Washington, 98105, United States
Washington State Univ Elson S. Floyd College of Medicine
RECRUITING

Spokane, Washington, 99202-2131, United States
Westmead Hospital for Medical Research
NOT_YET_RECRUITING

Westmead, 2145, Australia
Wojewodzki Szpital im. J Gromkowskiego we Wroclawiu
NOT_YET_RECRUITING

Wroclaw, Poland