New combo therapy aims to slow progressive MS disability

NCT ID NCT07282574

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study tests whether adding a new drug (RO7268489) to the standard MS treatment ocrelizumab can slow disability progression in adults with progressive multiple sclerosis. About 360 participants will receive either the new drug or a placebo, and researchers will track walking speed, hand function, and cognitive changes over time. The goal is to find a better way to manage this challenging form of MS.

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROGRESSIVE MULTIPLE SCLEROSIS

Contacts and locations

Locations

Ankara City Hospital
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Az. Osp. OO.RR. S. Giovanni di Dio e Ruggi D' Aragona
RECRUITING

Salerno, Campania, 84131, Italy
Azienda Ospedaliera Universitaria Federico II
RECRUITING

Naples, Campania, 80131, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata
RECRUITING

Roma, Emilia-Romagna, 00133, Italy
Azienda Ospedaliera Universitaria- Universit degli Studi della Campania Luigi Vanvitelli
RECRUITING

Naples, Campania, 80138, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
RECRUITING

Milan, Lombardy, 20162, Italy
Bajcsy-Zsilinszky Korhaz es Rendelointezet
RECRUITING

Budapest, 1106, Hungary
Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
Budapesti Uzsoki Utcai Kórház
RECRUITING

Budapest, 1145, Hungary
CHU Hopital Gabriel Montpied
RECRUITING

Clermont-Ferrand, Puy De Dome, 63003, France
CHU Nancy Hôpital Central
RECRUITING

Nancy, Meurthe Et Moselle, 54035, France
CHU Nantes - Hopital Nord Laënnec
RECRUITING

Saint-Herblain, Loire Atlantique, 44800, France
CHU Rennes - Hopital Pontchaillou
RECRUITING

Rennes, 35033, France
CHU Strasbourg Hpital Hautepierre
RECRUITING

Strasbourg, Bas Rhin, 67098, France
COPERNICUS Podmiot Leczniczy Sp z o o
RECRUITING

Gda?sk, 80-803, Poland
Centro Hospitalar Entre o Douro e Vouga E.P.E. - Hospital de São Sebastião
RECRUITING

Santa Maria da Feira, 4520-211, Portugal
Centrum Medyczne Medyk
RECRUITING

Rzeszów, 35-055, Poland
Centrum Medyczne NeuroProtect
RECRUITING

Warsaw, 01-684, Poland
Centrum Medyczne Pratia Katowice I
RECRUITING

Katowice, Silesian Voivodeship, 40-081, Poland
Charing Cross Hospital
RECRUITING

London, Greater London, W6 8RF, United Kingdom
Charité Universitaetsmedizin Berlin - Campus Ch
RECRUITING

Berlin, 10117, Germany
Clinexpert Kft.
RECRUITING

Budapest, 1033, Hungary
Complejo Hospitalario Universitario de Albacete
RECRUITING

Albacete, 02008, Spain
Complejo Hospitalario Universitario de Santiago.
RECRUITING

Santiago de Compostela, LA Coruna, 15706, Spain
Debreceni Egyetem Klinikai Kozpont Kenezy Gyula Campus
RECRUITING

Debrecen, 4031, Hungary
Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITING

Milan, Lombardy, 20133, Italy
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
RECRUITING

Pavia, Lombardy, 27100, Italy
Fondazione Università G. D'Annunzio
RECRUITING

Chieti, Abruzzo, 66013, Italy
Gazi University Medical Faculty
RECRUITING

Ankara, 06500, Turkey (Türkiye)
Groupe Hospitalier Pellegrin
RECRUITING

Bordeaux, Gironde, 33800, France
Groupe Hospitalier Pitie-Salpetriere
RECRUITING

Paris, 75013, France
Hacettepe University of Medicine
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Hopital Caremeau
RECRUITING

Nîmes, Gard, 30029, France
Hopital Gui de Chauliac
RECRUITING

Montpellier, Herault, 34295, France
Hopital Neurologique Pierre Wertheimer
RECRUITING

Bron, 69500, France
Hopital Purpan
RECRUITING

Toulouse, Haute Garonne, 31059, France
Hospital Alvaro Cunqueiro
RECRUITING

Vigo, Pontevedra, 36312, Spain
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital General Universitario Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, 29010, Spain
Hospital Santa Caterina
RECRUITING

Salt, Girona, 17190, Spain
Hospital Universitari Arnau de Vilanova
RECRUITING

Lleida, Lerida, 25198, Spain
Hospital Universitari Vall d Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitari de Bellvitge
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Quironsalud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Universitario Virgen de La Arrixaca
RECRUITING

El Palmar, Murcia, 30120, Spain
Hospital Universitario de la Princesa
RECRUITING

Madrid, 28006, Spain
Hospital de Braga
RECRUITING

Braga, 4710-243, Portugal
Hospital de Cruces
RECRUITING

Barakaldo, Vizcaya, 48903, Spain
Hospital de Egas Moniz
RECRUITING

Lisbon, 1349-019, Portugal
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08041, Spain
Hospital del Mar
RECRUITING

Barcelona, 08003, Spain
IRCCS AOM Azienda Ospedaliera Metropolitana
RECRUITING

Genoa, Liguria, 16132, Italy
Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.
RECRUITING

Lublin, 20-410, Poland
Istanbul University Cerrahpasa Medical Faculty
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Istanbul University Istanbul Medical Faculty
RECRUITING

Istanbul, 34093, Turkey (Türkiye)
John Hunter Hospital
RECRUITING

New Lambton Heights, New South Wales, 2305, Australia
Klinikum rechts der Isar der TU Muenchen
RECRUITING

Munich, Bavaria, 81675, Germany
Kocaeli University Medical Faculty
RECRUITING

Kocaeli, Izmit, 41380, Turkey (Türkiye)
LMU-Campus Grosshadern
RECRUITING

Munich, Bavaria, 81377, Germany
M.A. LEK A.M.Maciejowscy SC.
RECRUITING

Katowice, 40-571, Poland
Morriston Hospital
RECRUITING

Swansea, SA6 6NL, United Kingdom
NEURO-CARE Sp. z o.o. Sp. Komandytowa
RECRUITING

Katowice, Silesian Voivodeship, 40-749, Poland
Neurocentrum Bydgoszcz sp z o.o
RECRUITING

Bydgoszcz, 85-796, Poland
Nmedis sp. z o.o.
RECRUITING

Rzeszw, Podkarpackie Voivodeship, 35-323, Poland
Optimal Clinical Trials - Central
RECRUITING

Auckland, 1010, New Zealand
Optimal Clinical Trials - Christchurch
RECRUITING

Christchurch Central City, South Island, 8011, New Zealand
Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
Pecsi Tudomanyegyetem Klinikai Kozpont
RECRUITING

Pécs, Baranya, 7623, Hungary
Penta Hospitals Przychodnie, Wroclaw Wejherowska
RECRUITING

Wroc?aw, 54-239, Poland
ProNeuro Centrum Medyczne
RECRUITING

?ory, 44-240, Poland
Queen Elizabeth University Hospital
RECRUITING

Glasgow, Strathclyde, G51 4TF, United Kingdom
Resmedica NZOZ Kielce
RECRUITING

Kielce, 25-726, Poland
Royal Cornwall Hospital
RECRUITING

Truro, Cornwall, TR1 3HD, United Kingdom
Royal London Hospital
RECRUITING

London, E1 2AT, United Kingdom
S-Medicon Egeszsegugyi Szolgaltato Kft.
RECRUITING

Budapest, 1045, Hungary
SOMED - Lodzkie Centrum Osteoporozy
RECRUITING

?ód?, 90-368, Poland
Salford Care Organisation
RECRUITING

Salford, M6 8HD, United Kingdom
Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Stanislawa SzyszkoSUM w Katowicach
RECRUITING

Zabrze, 41-800, Poland
Samodzielny Publiczny Zakad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie
RECRUITING

Krakow, 31-503, Poland
Sancaktepe Sehit Prof Dr Ilhan Varank Training and Research Hospital
RECRUITING

Istanbul, 34785, Turkey (Türkiye)
Selcuk Universitesi Selcuklu Tip Fakultesi Hastanesi
RECRUITING

Konya, 42075, Turkey (Türkiye)
Southern Neurology
RECRUITING

Kogarah, New South Wales, 2217, Australia
St. Josef-Hospital Universitaetsklinikum
RECRUITING

Bochum, North Rhine-Westphalia, 44791, Germany
Studienzentrum Neuropoint GmbH,
RECRUITING

Ulm, Baden-Wurttemberg, 89073, Germany
Szpital Specjalistyczny im. L. Rydygiera w Krakowie
RECRUITING

Krakow, 31-826, Poland
ULS São José - Hospital de Sto António dos Capuchos;CRI Esclerose Múltipla
RECRUITING

Lisbon, 1169-050, Portugal
ULS de Coimbra, EPE - Hospitais da Universidade de Coimbra
RECRUITING

Coimbra, 3004-561, Portugal
Universitaetsklinikum Carl Gustav Carus TU Dresden
RECRUITING

Dresden, Saxony, 01307, Germany
Universitaetsklinikum Duesseldorf
RECRUITING

Düsseldorf, North Rhine-Westphalia, 40225, Germany
Universitaetsklinikum Erlangen
RECRUITING

Erlangen, Bavaria, 91054, Germany
Universitaetsklinikum Freiburg
RECRUITING

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Universitaetsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Leipzig
RECRUITING

Leipzig, Saxony, 04103, Germany
Universitaetsklinikum Tuebingen
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitaetsklinikum Ulm
RECRUITING

Ulm, Baden-Wurttemberg, 89081, Germany
University Hospital of Wales
RECRUITING

Cardiff, CF14 4XW, United Kingdom
Zanamed Medical Clinic sp z o o
RECRUITING

Lublin, 20-601, Poland

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