New combo therapy aims to slow progressive MS disability

NCT ID NCT07282574

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a new drug (RO7268489) to the standard MS treatment ocrelizumab can slow disability progression in adults with progressive multiple sclerosis. About 360 participants will receive either the new drug or a placebo, and researchers will track walking speed, hand function, and cognitive changes over time. The goal is to find a better way to manage this challenging form of MS.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROGRESSIVE MULTIPLE SCLEROSIS

Contacts and locations

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Study contacts

Contact
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Ankara City Hospital
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Az. Osp. OO.RR. S. Giovanni di Dio e Ruggi D' Aragona
RECRUITING

Salerno, Campania, 84131, Italy
Azienda Ospedaliera Universitaria Federico II
RECRUITING

Naples, Campania, 80131, Italy
Azienda Ospedaliera Universitaria- Universit degli Studi della Campania Luigi Vanvitelli
RECRUITING

Naples, Campania, 80138, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
RECRUITING

Milan, Lombardy, 20162, Italy
Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
Budapesti Uzsoki Utcai Kórház
RECRUITING

Budapest, 1145, Hungary
CHU Hopital Gabriel Montpied
RECRUITING

Clermont-Ferrand, Puy De Dome, 63003, France
CHU Nancy Hôpital Central
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Nancy, Meurthe Et Moselle, 54035, France
CHU Nantes - Hopital Nord Laënnec
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Saint-Herblain, Loire Atlantique, 44800, France
CHU Rennes - Hopital Pontchaillou
RECRUITING

Rennes, 35033, France
CHU Strasbourg Hpital Hautepierre
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Strasbourg, Bas Rhin, 67098, France
Centro Hospitalar Entre o Douro e Vouga E.P.E. - Hospital de São Sebastião
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Santa Maria da Feira, 4520-211, Portugal
Centrum Medyczne Medyk
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Rzeszów, 35-055, Poland
Centrum Medyczne NeuroProtect
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Warsaw, 01-684, Poland
Centrum Medyczne Pratia Katowice I
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Katowice, Silesian Voivodeship, 40-081, Poland
Charing Cross Hospital
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London, Greater London, W6 8RF, United Kingdom
Charité Universitaetsmedizin Berlin - Campus Ch
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Berlin, 10117, Germany
Clinexpert Kft.
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Budapest, 1033, Hungary
Complejo Hospitalario Universitario de Albacete
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Albacete, 02008, Spain
Fondazione IRCCS Istituto Neurologico Carlo Besta
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Milan, Lombardy, 20133, Italy
Fondazione Istituto Neurologico Nazionale Casimiro Mondino
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Pavia, Lombardy, 27100, Italy
Gazi University Medical Faculty
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Ankara, 06500, Turkey (Türkiye)
Groupe Hospitalier Pellegrin
RECRUITING

Bordeaux, Gironde, 33800, France
Groupe Hospitalier Pitie-Salpetriere
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Paris, 75013, France
Hacettepe University of Medicine
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Hopital Caremeau
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Nîmes, Gard, 30029, France
Hopital Gui de Chauliac
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Montpellier, Herault, 34295, France
Hopital Neurologique Pierre Wertheimer
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Bron, 69500, France
Hopital Purpan
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Toulouse, Haute Garonne, 31059, France
Hospital Alvaro Cunqueiro
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Vigo, Pontevedra, 36312, Spain
Hospital Clinic de Barcelona
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Barcelona, 08036, Spain
Hospital Clinico San Carlos
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Madrid, 28040, Spain
Hospital General Universitario Gregorio Maranon
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Madrid, 28007, Spain
Hospital Regional Universitario de Malaga
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Málaga, 29010, Spain
Hospital Santa Caterina
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Salt, Girona, 17190, Spain
Hospital Universitari Arnau de Vilanova
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Lleida, Lerida, 25198, Spain
Hospital Universitari Vall d Hebron
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Barcelona, 08035, Spain
Hospital Universitari de Bellvitge
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital Universitari i Politecnic La Fe
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Valencia, 46026, Spain
Hospital Universitario Quironsalud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Ramon y Cajal
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Madrid, 28034, Spain
Hospital Universitario Virgen Macarena
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Seville, 41009, Spain
Hospital Universitario Virgen de La Arrixaca
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El Palmar, Murcia, 30120, Spain
Hospital Universitario de la Princesa
RECRUITING

Madrid, 28006, Spain
Hospital de Braga
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Braga, 4710-243, Portugal
Hospital de Cruces
RECRUITING

Barakaldo, Vizcaya, 48903, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08041, Spain
Hospital del Mar
RECRUITING

Barcelona, 08003, Spain
IRCCS AOM Azienda Ospedaliera Metropolitana
RECRUITING

Genoa, Liguria, 16132, Italy
Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.
RECRUITING

Lublin, 20-410, Poland
Istanbul University Cerrahpasa Medical Faculty
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Istanbul University Istanbul Medical Faculty
RECRUITING

Istanbul, 34093, Turkey (Türkiye)
John Hunter Hospital
RECRUITING

New Lambton Heights, New South Wales, 2305, Australia
Klinikum rechts der Isar der TU Muenchen
RECRUITING

Munich, Bavaria, 81675, Germany
Kocaeli University Medical Faculty
RECRUITING

Kocaeli, Izmit, 41380, Turkey (Türkiye)
LMU-Campus Grosshadern
RECRUITING

Munich, Bavaria, 81377, Germany
M.A. LEK A.M.Maciejowscy SC.
RECRUITING

Katowice, 40-571, Poland
Morriston Hospital
RECRUITING

Swansea, SA6 6NL, United Kingdom
NEURO-CARE Sp. z o.o. Sp. Komandytowa
RECRUITING

Katowice, Silesian Voivodeship, 40-749, Poland
Nmedis sp. z o.o.
RECRUITING

Rzeszw, Podkarpackie Voivodeship, 35-323, Poland
Optimal Clinical Trials - Central
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Auckland, 1010, New Zealand
Optimal Clinical Trials - Christchurch
RECRUITING

Christchurch Central City, South Island, 8011, New Zealand
Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
Pecsi Tudomanyegyetem Klinikai Kozpont
RECRUITING

Pécs, Baranya, 7623, Hungary
Penta Hospitals Przychodnie, Wroclaw Wejherowska
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Wroc?aw, 54-239, Poland
ProNeuro Centrum Medyczne
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?ory, 44-240, Poland
Queen Elizabeth University Hospital
RECRUITING

Glasgow, Strathclyde, G51 4TF, United Kingdom
Resmedica NZOZ Kielce
RECRUITING

Kielce, 25-726, Poland
Royal Cornwall Hospital
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Truro, Cornwall, TR1 3HD, United Kingdom
Royal London Hospital
RECRUITING

London, E1 2AT, United Kingdom
S-Medicon Egeszsegugyi Szolgaltato Kft.
RECRUITING

Budapest, 1045, Hungary
SOMED - Lodzkie Centrum Osteoporozy
RECRUITING

?ód?, 90-368, Poland
Salford Care Organisation
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Salford, M6 8HD, United Kingdom
Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Stanislawa SzyszkoSUM w Katowicach
RECRUITING

Zabrze, 41-800, Poland
Samodzielny Publiczny Zakad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie
RECRUITING

Krakow, 31-503, Poland
Sancaktepe Sehit Prof Dr Ilhan Varank Training and Research Hospital
RECRUITING

Istanbul, 34785, Turkey (Türkiye)
Selcuk Universitesi Selcuklu Tip Fakultesi Hastanesi
RECRUITING

Konya, 42075, Turkey (Türkiye)
Southern Neurology
RECRUITING

Kogarah, New South Wales, 2217, Australia
St. Josef-Hospital Universitaetsklinikum
RECRUITING

Bochum, North Rhine-Westphalia, 44791, Germany
Studienzentrum Neuropoint GmbH,
RECRUITING

Ulm, Baden-Wurttemberg, 89073, Germany
Szpital Specjalistyczny im. L. Rydygiera w Krakowie
RECRUITING

Krakow, 31-826, Poland
ULS São José - Hospital de Sto António dos Capuchos;CRI Esclerose Múltipla
RECRUITING

Lisbon, 1169-050, Portugal
Universitaetsklinikum Carl Gustav Carus TU Dresden
RECRUITING

Dresden, Saxony, 01307, Germany
Universitaetsklinikum Erlangen
RECRUITING

Erlangen, Bavaria, 91054, Germany
Universitaetsklinikum Freiburg
RECRUITING

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Universitaetsklinikum Leipzig
RECRUITING

Leipzig, Saxony, 04103, Germany
Universitaetsklinikum Tuebingen
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
University Hospital of Wales
RECRUITING

Cardiff, CF14 4XW, United Kingdom
Zanamed Medical Clinic sp z o o
RECRUITING

Lublin, 20-601, Poland