New drug combo shows promise against childhood cancer

NCT ID NCT07549321

Recruiting now Disease control Sponsor: Renaissance Pharma Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study tests whether adding an antibody drug called hu14.18K322A to standard chemotherapy helps children with high-risk neuroblastoma, a rare but aggressive childhood cancer. About 144 children and teens aged 18 months to 18 years will receive the combination over up to 12 cycles. Researchers will measure how many patients' tumors shrink or disappear, and track survival over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hu14.18K322A (daretabart) combined with temozolomide and irinotecan
What this could lead to: If successful, this combination could improve response rates and survival for children with high-risk neuroblastoma, potentially leading to a new standard treatment.
What could go wrong: This is an early-to-mid-stage trial with only 144 participants, so results may not apply to all patients. The treatment involves chemotherapy, which carries significant side effects like infection and organ damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH-RISK NEUROBLASTOMA

Contacts and locations

Locations

Children's Hospital Colorado Anschutz Medical
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27705, United States
The Children's Hospital at Montefiore
RECRUITING

The Bronx, New York, 10467, United States
The Hospital for Sick Children
RECRUITING

Toronto, Ontario, M5G 1E8, Canada
University of Minnesota Masonic Children's Hospital
RECRUITING

Minneapolis, Minnesota, 55454, United States

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