New antibody combo shows promise in tough childhood cancer
NCT ID NCT01041638
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tested the safety of giving a monoclonal antibody (dinutuximab) along with immune-boosting drugs and a vitamin-like drug to children with high-risk neuroblastoma after a stem cell transplant. The goal was to see if this combination could be given safely and help prevent the cancer from coming back. 105 children participated, and the study tracked serious side effects like pain, allergic reactions, and low blood pressure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dinutuximab (Ch14.18 antibody) plus sargramostim (GM-CSF), aldesleukin (IL-2), and isotretinoin
What this could lead to
If successful, this combination could become a standard post-transplant therapy to improve survival in children with high-risk neuroblastoma.
What could go wrong
This trial primarily measures safety, not effectiveness. Side effects like pain, low blood pressure, and allergic reactions are common. The long-term benefit is still uncertain.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HIGH-RISK NEUROBLASTOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030, United States
-
C S Mott Children's Hospital
Ann Arbor, Michigan, 48109, United States
-
Children's Healthcare of Atlanta - Egleston
Atlanta, Georgia, 30322, United States
-
Children's Hospital Colorado
Aurora, Colorado, 80045, United States
-
Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
-
Children's Hospital New Orleans
New Orleans, Louisiana, 70118, United States
-
Children's Hospital of Orange County
Orange, California, 92868, United States
-
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
-
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, 55404, United States
-
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, 64108, United States
-
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
-
Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
-
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
-
Duke University Medical Center
Durham, North Carolina, 27710, United States
-
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
-
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202, United States
-
Loma Linda University Medical Center
Loma Linda, California, 92354, United States
-
Lucile Packard Children's Hospital Stanford University
Palo Alto, California, 94304, United States
-
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
-
New York Medical College
Valhalla, New York, 10595, United States
-
Rady Children's Hospital - San Diego
San Diego, California, 92123, United States
-
Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
-
Saint Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
-
Seattle Children's Hospital
Seattle, Washington, 98105, United States
-
UCSF Medical Center-Mount Zion
San Francisco, California, 94115, United States
-
UCSF Medical Center-Parnassus
San Francisco, California, 94143, United States
-
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390, United States
-
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
-
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455, United States
-
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, 53792, United States
-
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
-
Washington University School of Medicine
St Louis, Missouri, 63110, United States