New antibody combo shows promise in tough childhood cancer

NCT ID NCT01041638

Completed Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested the safety of giving a monoclonal antibody (dinutuximab) along with immune-boosting drugs and a vitamin-like drug to children with high-risk neuroblastoma after a stem cell transplant. The goal was to see if this combination could be given safely and help prevent the cancer from coming back. 105 children participated, and the study tracked serious side effects like pain, allergic reactions, and low blood pressure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dinutuximab (Ch14.18 antibody) plus sargramostim (GM-CSF), aldesleukin (IL-2), and isotretinoin
What this could lead to: If successful, this combination could become a standard post-transplant therapy to improve survival in children with high-risk neuroblastoma.
What could go wrong: This trial primarily measures safety, not effectiveness. Side effects like pain, low blood pressure, and allergic reactions are common. The long-term benefit is still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

neuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH-RISK NEUROBLASTOMA

Contacts and locations

Locations

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
C S Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States
Children's Healthcare of Atlanta - Egleston

Atlanta, Georgia, 30322, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital New Orleans

New Orleans, Louisiana, 70118, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, Minnesota, 55404, United States
Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Loma Linda University Medical Center

Loma Linda, California, 92354, United States
Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94304, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
New York Medical College

Valhalla, New York, 10595, United States
Rady Children's Hospital - San Diego

San Diego, California, 92123, United States
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Saint Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
UCSF Medical Center-Mount Zion

San Francisco, California, 94115, United States
UCSF Medical Center-Parnassus

San Francisco, California, 94143, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.