Head-to-Head: which antidepressant eases unexplained pain better?
NCT ID NCT06803485
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study compares two antidepressants, venlafaxine and dosulepin, in 84 adults with somatic symptom disorder where pain is the main complaint. Participants take one of the drugs for 8 weeks. Researchers will measure changes in pain and other symptoms, as well as levels of stress hormone cortisol and inflammation markers. The goal is to find which drug works better and why.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Venlafaxine and dosulepin
What this could lead to
If this trial succeeds, it could help doctors choose between two antidepressants for managing pain and other symptoms in somatic symptom disorder.
What could go wrong
This is a small, early-phase trial with only 84 participants. The results may not apply to everyone, and both drugs have side effects like nausea, dizziness, and drowsiness.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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All India Institute of Medical Sciences (AIIMS)
RECRUITINGBhubaneswar, Odisha, 751019, India
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••