Head-to-Head: which antidepressant eases unexplained pain better?
NCT ID NCT06803485
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study compares two antidepressants, venlafaxine and dosulepin, in 84 adults with somatic symptom disorder where pain is the main complaint. Participants take one of the drugs for 8 weeks. Researchers will measure changes in pain and other symptoms, as well as levels of stress hormone cortisol and inflammation markers. The goal is to find which drug works better and why.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Venlafaxine and dosulepin
- What this could lead to
- If this trial succeeds, it could help doctors choose between two antidepressants for managing pain and other symptoms in somatic symptom disorder.
- What could go wrong
- This is a small, early-phase trial with only 84 participants. The results may not apply to everyone, and both drugs have side effects like nausea, dizziness, and drowsiness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
All India Institute of Medical Sciences (AIIMS)
RECRUITINGBhubaneswar, Odisha, 751019, India