Somatization disorder
MONDO:0001830Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by a another medical condition, by the direct effects of a substance, or by another mental disorder. The symptoms must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to factitious disorders and malingering, the physical symptoms are not under voluntary control. (apa, dsm-V)
Also known as: Briquet's disorder
53 clinical trials for this condition and its sub-types.
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Brain zaps to kick the habit: TMS trial targets smokers with mental health struggles
Disease control Recruiting nowThis study tests whether a non-invasive brain stimulation technique called TMS can help people with mental illness quit smoking. Forty daily smokers with psychiatric conditions will receive either TMS or standard care. The goal is to see if TMS is practical and effective in real-…
Phase: PHASE4 • Sponsor: Centre for Addiction and Mental Health • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Smartphone app tests music and thought exercises to reduce daily distress from unexplained physical symptoms
Symptom relief Recruiting nowThis study explores whether listening to happy music or practicing cognitive reappraisal (thinking about symptoms in a more helpful way) can reduce the intensity and impairment of persistent physical symptoms in people with Somatic Symptom Disorder. Forty adults aged 18–65 will u…
Phase: NA • Sponsor: University of Vienna • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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New program aims to ease mental health struggles by targeting shared roots
Symptom relief Recruiting nowThis study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…
Phase: NA • Sponsor: University Hospital, Tours • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Could a cough medicine combo ease OCD symptoms?
Symptom relief Recruiting nowThis study tests whether adding dextromethorphan (a cough suppressant) to fluoxetine (an antidepressant) can safely reduce symptoms of obsessive-compulsive disorder (OCD) and related conditions like body dysmorphic disorder. About 60 adults in California will take the combination…
Phase: PHASE2 • Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Could VR therapy help heal emotional wounds?
Symptom relief Recruiting nowThis study is testing whether a virtual reality version of a therapy exercise is practical and helpful for adults (ages 18-65) with psychiatric disorders. Participants will try one VR session and answer questions about their experience. The goal is to see if this approach is acce…
Phase: NA • Sponsor: University Medical Center Groningen • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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Could magnetic pulses to the brain ease unexplained physical symptoms?
Symptom relief Recruiting nowThis study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce physical distress and health anxiety in people with somatic symptom disorder. Thirty adults aged 20–70 will receive either real or sham rTMS i…
Phase: NA • Sponsor: National Taiwan University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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New online therapy aims to quiet the inner critic
Symptom relief Recruiting nowThis study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered over video for people in New York who struggle with worry, overthinking, or being hard on themselves. The goal is to see if the therapy helps people better manage their emotions and fee…
Phase: NA • Sponsor: Teachers College, Columbia University • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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New sleep aid studied for those with mental illness
Symptom relief Recruiting nowThis study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …
Sponsor: Shanghai Mental Health Center • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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Sailing therapy: a new wind for psychiatric care?
Symptom relief Recruiting nowThis study tests whether sailing can help people with psychiatric disorders feel better. Forty adults in France will either take sailing lessons or continue their usual care. Researchers will measure changes in quality of life, mental well-being, and self-esteem to see if sailing…
Phase: NA • Sponsor: Centre hospitalier de Ville-Evrard, France • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Could zapping the brain relieve stubborn constipation?
Symptom relief Recruiting nowThis study tests whether a non-invasive brain stimulation technique called tACS can help people with severe constipation that hasn't improved with standard treatments, especially when they also have stress-related physical symptoms. About 60 adults will receive either real or sha…
Phase: NA • Sponsor: Xijing Hospital of Digestive Diseases • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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New Mind-Body therapy aims to ease unexplained physical symptoms
Symptom relief Recruiting nowThis study tests a new therapy that combines cognitive-behavioral therapy (CBT) with biofeedback to help people with somatic symptom disorder—a condition where physical distress has no clear medical cause. Sixty adults will receive eight sessions over three months or be placed on…
Phase: NA • Sponsor: National Taiwan University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Head-to-Head: which antidepressant eases unexplained pain better?
Symptom relief Recruiting nowThis study compares two antidepressants, venlafaxine and dosulepin, in 84 adults with somatic symptom disorder where pain is the main complaint. Participants take one of the drugs for 8 weeks. Researchers will measure changes in pain and other symptoms, as well as levels of stres…
Phase: PHASE4 • Sponsor: All India Institute of Medical Sciences, Bhubaneswar • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Can a 48-Hour psychiatrist booking system keep patients out of the ER?
Knowledge-focused Recruiting nowThis study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…
Phase: NA • Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Study to uncover hidden mental health struggles in teens at special schools
Knowledge-focused Recruiting nowThis study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Can data sharing prevent suicide among Jail-Cycling individuals?
Knowledge-focused Recruiting nowThis study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…
Phase: NA • Sponsor: Cambridge Health Alliance • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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New study tests nurse support for Ex-Prisoners' health
Knowledge-focused Recruiting nowThis study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …
Phase: NA • Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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New program aims to ease Veterans' return from prison
Knowledge-focused Recruiting nowThis study is creating a program called START-VET to help veterans with mental illness or substance use disorders who have recently left prison. Researchers will work with 20 veterans to develop transition materials and tools. The goal is to improve quality of life and reduce cri…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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Could emotional awareness explain unexplained pain in kids?
Knowledge-focused Recruiting nowThis study looks at how emotional awareness, attachment style, and thinking skills relate to physical symptoms like stomach pain or headaches in children. Researchers will assess 300 children with somatic symptom disorder using questionnaires and tests. The goal is to understand …
Sponsor: Meyer Children's Hospital IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Spit test could take guesswork out of mental health prescriptions
Knowledge-focused Recruiting nowThis pilot study is testing whether a simple saliva test can help doctors prescribe mental health medications more safely and effectively. 200 adults in Manitoba who are starting or changing psychiatric drugs will provide a DNA sample. The results will be shared with their doctor…
Phase: NA • Sponsor: University of Manitoba • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:55 UTC
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Can training psychiatric staff improve sexual health talks with teens?
Knowledge-focused Recruiting nowThis study looks at whether training psychiatric care teams to talk about sexual health with young patients (ages 15 and up) increases those conversations. Researchers will survey 770 teens hospitalized for psychiatric disorders about their sexual health and any side effects from…
Sponsor: Fondation Santé des Étudiants de France • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:35 UTC