Somatization disorder
MONDO:0001830Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by a another medical condition, by the direct effects of a substance, or by another mental disorder. The symptoms must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to factitious disorders and malingering, the physical symptoms are not under voluntary control. (apa, dsm-V)
Also known as: Briquet's disorder
22 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Smartphone app tests music and thought exercises to reduce daily distress from unexplained physical symptoms
Symptom relief Recruiting nowThis study explores whether listening to happy music or practicing cognitive reappraisal (thinking about symptoms in a more helpful way) can reduce the intensity and impairment of persistent physical symptoms in people with Somatic Symptom Disorder. Forty adults aged 18–65 will u…
Phase: NA • Sponsor: University of Vienna • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Could a cough medicine combo ease OCD symptoms?
Symptom relief Recruiting nowThis study tests whether adding dextromethorphan (a cough suppressant) to fluoxetine (an antidepressant) can safely reduce symptoms of obsessive-compulsive disorder (OCD) and related conditions like body dysmorphic disorder. About 60 adults in California will take the combination…
Phase: PHASE2 • Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Could magnetic pulses to the brain ease unexplained physical symptoms?
Symptom relief Recruiting nowThis study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce physical distress and health anxiety in people with somatic symptom disorder. Thirty adults aged 20–70 will receive either real or sham rTMS i…
Phase: NA • Sponsor: National Taiwan University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Could zapping the brain relieve stubborn constipation?
Symptom relief Recruiting nowThis study tests whether a non-invasive brain stimulation technique called tACS can help people with severe constipation that hasn't improved with standard treatments, especially when they also have stress-related physical symptoms. About 60 adults will receive either real or sha…
Phase: NA • Sponsor: Xijing Hospital of Digestive Diseases • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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New Mind-Body therapy aims to ease unexplained physical symptoms
Symptom relief Recruiting nowThis study tests a new therapy that combines cognitive-behavioral therapy (CBT) with biofeedback to help people with somatic symptom disorder—a condition where physical distress has no clear medical cause. Sixty adults will receive eight sessions over three months or be placed on…
Phase: NA • Sponsor: National Taiwan University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Head-to-Head: which antidepressant eases unexplained pain better?
Symptom relief Recruiting nowThis study compares two antidepressants, venlafaxine and dosulepin, in 84 adults with somatic symptom disorder where pain is the main complaint. Participants take one of the drugs for 8 weeks. Researchers will measure changes in pain and other symptoms, as well as levels of stres…
Phase: PHASE4 • Sponsor: All India Institute of Medical Sciences, Bhubaneswar • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Could emotional awareness explain unexplained pain in kids?
Knowledge-focused Recruiting nowThis study looks at how emotional awareness, attachment style, and thinking skills relate to physical symptoms like stomach pain or headaches in children. Researchers will assess 300 children with somatic symptom disorder using questionnaires and tests. The goal is to understand …
Sponsor: Meyer Children's Hospital IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC