Somatoform disorder
MONDO:0003117A category of psychiatric disorders which are characterized by the presence of physical symptoms that suggest a medical condition but are not fully explained by any known medical reasons.
Also known as: somatoform disorder, physiological malfunction arising from mental factor, psychophysiologic disorder, psychosomatic disorder
139 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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New community program targets COPD and mental health together
Disease control CompletedThis completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…
Phase: NA • Sponsor: Peking Union Medical College • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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Liver cancer remission: is surgery still needed?
Disease control CompletedThis study looked at liver cancer patients whose tumors shrank completely after non-surgical treatments like chemoembolization and immunotherapy. Researchers compared those who then had surgery to remove any remaining tissue versus those who simply watched and waited. The goal wa…
Phase: PHASE2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Mediterranean diet shows promise for metabolic health in psychiatric patients
Disease control CompletedThis completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …
Phase: NA • Sponsor: King Saud University • Aim: Disease control
Last updated Jun 26, 2026 15:01 UTC
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Could your phone replace a $1,000 Back-Flexibility device?
Diagnosis CompletedThis study compares a smartphone app (iPhone Level) to a specialized device (BROM) for measuring how much the lower back can bend forward, backward, and sideways. Researchers will enroll 120 healthy male university students aged 18–25 with normal body weight. If the app works wel…
Sponsor: Cairo University • Aim: Diagnosis
Last updated Jul 04, 2026 00:00 UTC
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New checklist could help heart patients get the right diagnosis
Diagnosis CompletedThis study tested a new questionnaire called SSS-CN to see if it can accurately detect somatic symptom disorder (physical discomfort with no clear medical cause) in heart clinic patients. Over 1,800 adults aged 18-80 who had no diagnosed physical illness completed the checklist a…
Sponsor: RenJi Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 07:52 UTC
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Can talk therapy rewire the Brain's body image? a new trial investigates CBT for BDD
Symptom relief CompletedThis study tests whether a specific type of talk therapy called cognitive behavioral therapy (CBT) can help people with body dysmorphic disorder (BDD). Participants receive 22 weekly one-on-one CBT sessions that teach them to challenge negative thoughts and behaviors about their …
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jul 04, 2026 00:00 UTC
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Can an online program ease the distress of unexplained physical symptoms?
Symptom relief CompletedThis study tested whether an internet-based exposure therapy program can reduce distress related to physical symptoms better than standard education about healthy lifestyle habits. 161 adults in Stockholm with significant distress from somatic symptoms participated. The treatment…
Phase: NA • Sponsor: Region Stockholm • Aim: Symptom relief
Last updated Jun 27, 2026 14:03 UTC
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Shocking therapy may help kids with CP move better
Symptom relief CompletedThis study tested whether task-specific electrical stimulation can improve upper limb motor skills in 30 children aged 4 to 7 with spastic quadriplegia cerebral palsy. The therapy uses mild electrical pulses to activate muscles during functional tasks. The goal was to see if this…
Phase: NA • Sponsor: Kafrelsheikh University • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Can a smartphone app ease mysterious body aches? new study says maybe.
Symptom relief CompletedThis study tested whether a mobile app could help adults with somatic symptom disorder or medically unexplained symptoms. 46 participants used the app for 8 weeks, which taught coping skills like mindfulness and stress management. The goal was to see if symptoms improved compared…
Phase: NA • Sponsor: Gangnam Severance Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Teens with chronic pain try coaching to ease suffering
Symptom relief CompletedThis study tested a resilience coaching program (PRISM) for 260 teens aged 12-17 with chronic musculoskeletal pain. The goal was to see if coaching improves daily function, reduces distress, and lessens pain compared to usual care. Participants completed surveys and coaching sess…
Phase: NA • Sponsor: Children's Hospital of Philadelphia • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Video game therapy shows promise for mental health
Symptom relief CompletedThis study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…
Phase: NA • Sponsor: University of Salamanca • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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New hope for HIV nerve pain: Drug-Free relief on the horizon?
Symptom relief CompletedThis study tested new non-drug treatments to reduce nerve pain in the feet and legs of people with HIV. 161 adults with HIV-related nerve pain tried these approaches to see if they could ease pain and improve quality of life. The goal was to find better ways to manage this common…
Phase: NA • Sponsor: New York University • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Brain stimulation shows promise for unexplained paralysis
Symptom relief CompletedThis study tested whether a non-invasive brain stimulation technique called rTMS could help people with psychogenic paralysis (paralysis with no physical cause). 66 participants received two sessions of either real or sham rTMS over two days. The main goal was to see if paralysis…
Phase: NA • Sponsor: University Hospital, Rouen • Aim: Symptom relief
Last updated Jun 27, 2026 12:10 UTC
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Laser showdown: which light works best for frozen shoulder?
Symptom relief CompletedThis study tested two laser treatments—low-level and high-intensity—in 40 people with frozen shoulder (adhesive capsulitis). The goal was to see which better reduces pain, improves shoulder movement, and boosts daily function over three weeks. Both treatments are non-invasive and…
Phase: NA • Sponsor: Necmettin Erbakan University • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Talking it out: CBT may rewire Brain's response to body image fears
Symptom relief CompletedThis study looked at whether 12 weeks of Cognitive-Behavioral Therapy (CBT) can help people with Body Dysmorphic Disorder (BDD), a condition where someone is overly worried about small or imagined flaws in how they look. Sixty adults took part; half received weekly CBT sessions, …
Phase: NA • Sponsor: Istanbul Nisantasi University • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Simple muscle relaxation technique shows promise for stressed nursing students
Symptom relief CompletedThis study tested whether progressive muscle relaxation (PMR) — a technique where you tense and then relax different muscle groups — could help nursing students feel less depressed, anxious, and stressed. Over 100 students were split into two groups; one group practiced PMR three…
Phase: NA • Sponsor: Ondokuz Mayıs University • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Could magnetic pulses ease mysterious movement problems?
Symptom relief CompletedThis pilot study tested whether transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, can improve motor symptoms in people with functional neurological disorder (FND). Fifty-one adults with limb weakness received TMS over the motor cortex. The study…
Phase: NA • Sponsor: King's College London • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Can medical assistants ease health anxiety? new study says yes
Symptom relief CompletedThis study tested a short, four-session therapy program for people who worry excessively about their health. Medical assistants delivered the therapy in primary care clinics. 68 adults took part, and the study measured changes in health anxiety over 12 weeks. The goal was to see …
Phase: NA • Sponsor: Dartmouth-Hitchcock Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Talk therapy over video may ease Stress-Related seizures
Symptom relief CompletedThis pilot study tested whether prolonged exposure teletherapy can help adults with psychogenic nonepileptic seizures (PNES) and PTSD. Forty-four participants received either the teletherapy or standard education about PNES. The goal was to see if the therapy reduces seizure freq…
Phase: NA • Sponsor: Northeast Regional Epilepsy Group • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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App-Based CBT shows promise for functional tremor
Symptom relief CompletedThis study tested a 4-week app-based cognitive behavioral therapy (CBT) program in 20 people with functional tremor. Participants used the app to practice reframing upsetting thoughts and were compared to a group that simply reflected on their day. The goal was to see if the CBT …
Phase: NA • Sponsor: Medical University of Graz • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Could EMDR therapy help calm the Brain's faulty signals?
Symptom relief CompletedThis study tested whether a therapy called EMDR (eye movement desensitisation and reprocessing) could help people with functional neurological disorder (FND), a condition where the brain doesn't send signals properly, causing symptoms like seizures, shaking, or weakness. Fifty ad…
Phase: NA • Sponsor: South West London and St George's Mental Health NHS Trust • Aim: Symptom relief
Last updated Jun 26, 2026 18:33 UTC
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Group therapy shows promise for teens battling anxiety and depression
Symptom relief CompletedThis study tested a group version of a therapy program called the Unified Protocol for teens with emotional disorders like anxiety and depression. Thirty-one adolescents took part in 16 weekly group sessions at a public mental health center in Spain, along with three parent sessi…
Phase: NA • Sponsor: Universidad Nacional de Educación a Distancia • Aim: Symptom relief
Last updated Jun 26, 2026 17:39 UTC
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Texting away anxiety: smartphone study targets appearance worries
Symptom relief CompletedThis study tested whether text message reminders to stop 'safety behaviors' (like checking mirrors or seeking reassurance) could ease appearance concerns. 401 adults with body dysmorphic disorder, social anxiety, or eating disorders were split into two groups: one received text p…
Phase: NA • Sponsor: Florida State University • Aim: Symptom relief
Last updated Jun 26, 2026 17:16 UTC
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Can peers help others recover? small study tests new program
Knowledge-focused CompletedThis study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…
Phase: NA • Sponsor: National Cheng-Kung University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Pregnant Women's internet health searches linked to anxiety, study finds
Knowledge-focused CompletedThis study looked at how pregnant women's online health information seeking (cyberchondria) relates to their anxiety levels and how they perceive their own health. 166 pregnant women completed questionnaires about their internet health habits, anxiety, and health perception. The …
Sponsor: Karabuk University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Brain scans and thinking tests aim to unlock secrets of Self-Harm
Knowledge-focused CompletedThis study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…
Sponsor: Region Skane • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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Peer support after psychiatric stay shows promise in small VA study
Knowledge-focused CompletedThis study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Can smartphones replace In-Person therapy during a pandemic?
Knowledge-focused CompletedThis study looked at whether digital services like smartphone apps can help people with psychosomatic disorders continue their treatment during the COVID-19 pandemic, when social distancing and hygiene rules limit in-person therapy. About 2000 patients from clinics took part, usi…
Phase: NA • Sponsor: Jacobs University Bremen gGmbH • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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New program aims to help Long-COVID patients with online screening and personal support
Knowledge-focused CompletedThis study tested a program for people with long-COVID that includes an online screening, a detailed in-person assessment, and digital training modules with a personal counselor. 192 participants from Bavaria took part to see if this approach is practical and helpful. The goal wa…
Phase: NA • Sponsor: Prof. Dr. Sonia Lippke • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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New study reveals three types of PNES seizures
Knowledge-focused CompletedThis completed study looked at video-EEG recordings from 50 adults with psychogenic nonepileptic seizures (PNES). Researchers aimed to identify distinct patterns in how these seizures look and behave. They classified events into three clusters based on features like movement and …
Sponsor: Tepecik Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Brain wave study sheds light on PNES seizures
Knowledge-focused CompletedThis completed study looked back at the records of 50 adults diagnosed with psychogenic nonepileptic seizures (PNES) who had video-EEG monitoring. Researchers reviewed the video and brain wave data to describe the different types of seizure movements and other features. The goal …
Sponsor: Saglik Bilimleri Universitesi • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Sleep struggles widespread in psychiatric wards
Knowledge-focused CompletedThis study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.
Sponsor: University of Bern • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Brain zaps reveal how BDD patients see faces differently
Knowledge-focused CompletedThis completed study looked at how a noninvasive brain stimulation technique called TMS affects the way people with body dysmorphic disorder (BDD) process visual information. Forty adults with BDD or mild symptoms received either intermittent or continuous TMS over the parietal b…
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Can doing meaningful activities boost recovery in mental illness? new study says maybe.
Knowledge-focused CompletedThis study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…
Phase: NA • Sponsor: Amager Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Jaw pain linked to personality and social support in new study
Knowledge-focused CompletedThis study looked at how certain personality traits, physical symptoms without clear cause, and social support relate to temporomandibular joint (TMJ) disorders, which cause jaw pain and difficulty chewing. Researchers compared 90 adults with TMJ disorders to healthy volunteers u…
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Brain training shows promise for anxiety in small study
Knowledge-focused CompletedThis study tested whether real-time fMRI neurofeedback can help people with anxiety disorders better regulate their emotions. 21 participants practiced cognitive reappraisal while receiving feedback on their prefrontal cortex activity. The goal was to understand the brain mechani…
Phase: NA • Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Brain scans may predict recovery in conversion disorder
Knowledge-focused CompletedThis study looked at 20 people with a first episode of motor conversion disorder, a condition where psychological stress causes physical symptoms like paralysis. Researchers used PET scans to measure brain metabolism at the start of symptoms and checked if those patterns related …
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Scientists hunt for biological clues in mysterious movement disorder
Knowledge-focused CompletedThis study examined 20 adults experiencing their first episode of conversion disorder (a condition where psychological stress causes physical symptoms like paralysis or abnormal movements). Researchers measured inflammation markers in the blood and compared them with brain scans …
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Large study reveals how age affects unexplained physical symptoms
Knowledge-focused CompletedThis study looked at over 9,000 people in China to compare how often older and younger adults experience physical symptoms without a clear medical cause, like pain or fatigue. Researchers used questionnaires to measure these symptoms, along with depression and anxiety. The goal w…
Sponsor: RenJi Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Hidden ADHD: study reveals how many adults are undiagnosed
Knowledge-focused CompletedThis completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…
Sponsor: Takeda • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC