GYNECOLOGIC CANCER

This early-stage trial tests a new treatment for people with advanced solid tumors (like head and neck, melanoma, or lung cancer). Doctors take a patient's own immune cells from the tumor, grow them into billions, and give them back as a one-time infusion. Some cells are also mod…

This study tests two drugs, pembrolizumab and lenvatinib, in 30 people with recurrent clear cell ovarian cancer. The goal is to see if the combination can shrink tumors or slow cancer growth. Participants must have had at least one prior treatment and measurable disease.

This early-stage trial tests a new treatment called FT536 for people with ovarian, fallopian tube, or primary peritoneal cancer that has returned after prior therapy. The treatment is given directly into the abdomen three times in one week, after a short course of chemotherapy to…

This study tests whether using MRI during brachytherapy (a type of internal radiation) can help doctors deliver treatment more accurately for gynecologic cancer. About 49 participants will receive standard brachytherapy, some with an MRI tracker to guide the procedure. The goal i…

This study tests a new type of DCE-MRI scan to see if it produces clearer, more detailed images of gynecologic cancers than traditional MRI. The faster scan reduces blurring from movement and may give doctors better information about tumor activity. About 24 women with gynecologi…

This study tests a new program that combines physical therapy with coping skills training to help women who have had pelvic radiation for cancer improve their sexual function. The program is designed for cancer survivors who completed radiation within the last 5 years. The study …

This study looks at whether a 12-week program of online chair-based exercise and health education, combined with a geriatric assessment, is feasible and helpful for older adults (65+) with cancer and their support person. The goal is to improve physical function and well-being. T…

This study tests a device called SensoniQ® that uses low-frequency soundwaves to prevent or reduce nerve pain caused by chemotherapy in people with gynecologic cancer. About 80 participants will either receive the treatment while starting chemo or after having persistent nerve pa…

This study tests a program called Journey Ahead that helps women with gynecologic cancers (like ovarian, endometrial, or cervical cancer) improve their coping and communication skills. About 30 women who have been diagnosed or had a recurrence in the past 5 years will take part. …

This study tests a program that helps cancer patients and their caregivers manage difficult emotions and communicate better about the illness. It includes a version tailored for Latinx participants. The goal is to reduce distress, improve quality of life, and help families discus…

This study looks at how gynecological cancer survivors feel and function after finishing their main treatment. About 1,100 women who are currently cancer-free will fill out questionnaires about their quality of life, anxiety, and sexual health. The goal is to learn what matters m…

This study looks at 100 women with breast or gynecological cancer to see if their diet before starting chemotherapy affects levels of a protein called hepcidin. Researchers want to know if hepcidin levels are linked to how much of the planned chemotherapy dose patients actually r…

This study aims to measure oxygen levels inside cervical cancer tumors during a standard treatment called brachytherapy. About 10 adults with cervical cancer will have a tiny sensor placed in their tumor to record oxygen. The goal is to learn how oxygen levels relate to treatment…

This pilot study tests a different way of using a breathing machine (APRV) during anesthesia for robotic gynecologic or genitourinary cancer surgery, comparing it to the standard method (CMV). The goal is to see if APRV improves lung function during the operation. Twelve adult ca…

This study looks at whether patients with gynecologic cancer can regularly fill out electronic questionnaires about their symptoms before, during, and after radiation treatment. The goal is to see if this approach is practical in a busy clinic. About 100 English-speaking adults a…

This study was designed to see if a mobile health app helps patients with recurrent head and neck or gynecologic cancers track their symptoms and quality of life. Researchers planned to ask patients about their experience using the app and whether they found it easy and useful. T…

This study looks at whether a website and a genetic family navigator can help more family members of people with hereditary cancer get genetic testing. About 205 adults who have a known cancer gene mutation and their relatives will take part. The goal is to see if this approach m…