GYNECOLOGIC CANCER

This study is testing whether custom 3D-printed devices can improve a type of internal radiation therapy (brachytherapy) for gynecologic cancers. The goal is to see if these patient-specific devices are a feasible, more precise, and comfortable alternative to the standard wax mol…

This study is testing whether the oral drug belzutifan can help control recurrent clear cell cancers of the ovary, uterus, cervix, and other gynecologic sites. It will enroll 32 adults who have already received platinum-based chemotherapy. Researchers will measure how well the dr…

This study is testing a specialized radiation technique for patients with cervical cancer or pelvic recurrences who cannot receive standard internal radiation (brachytherapy). The goal is to see if this method can control the cancer in the treated area while limiting damage to ne…

This Canadian study is testing whether a personalized approach to cancer treatment works. It gives the immunotherapy drug atezolizumab to about 200 patients with advanced breast, lung, or other cancers, but only if their tumor's genetic analysis suggests they might respond. The g…

This study is testing a new way to help women after finishing initial treatment for ovarian or endometrial cancer. It compares a personalized support plan that includes a team assessment in a day hospital to a standard plan without that extra step. The goal is to see if the more …

This study is testing a new support program for cancer survivors who struggle to afford or access healthy food. Researchers will compare 100 patients who receive help from a patient navigator to those getting standard care, to see if the program improves food security, diet quali…

This early-stage trial is testing whether a modified immune cell therapy called FT536 can help control recurrent ovarian, fallopian tube, or primary peritoneal cancers. Participants receive chemotherapy followed by FT536 delivered directly into the abdomen through a temporary cat…

This early-stage study is testing a new type of personalized cell therapy called GC203 TIL in adults with advanced solid tumors that have stopped responding to standard treatments. Doctors take a patient's own immune cells from a tumor, modify them in a lab to potentially fight c…

This study aims to find out which of two common breathing machine settings is safer for patients undergoing gynecologic surgery. Researchers will compare how the settings affect lung pressure and brain oxygen levels in 120 patients. The goal is to reduce the risk of lung collapse…

This study is testing a new, faster type of MRI scan to see if it can provide clearer, more detailed pictures of gynecologic tumors. The goal is to help doctors get better information about the tumor's activity to guide treatment decisions. The study will involve 20 women, some w…

This study is testing whether a relaxation technique called guided imagery can help women with gynecologic cancer feel better during chemotherapy. Researchers will compare two groups: one that practices guided imagery and one that receives standard information. They want to see i…

This study is testing whether a drug called riluzole can help prevent the memory and thinking problems often called 'chemo brain' in people receiving chemotherapy for various cancers. About 24 adult patients will be randomly assigned to receive either riluzole or a placebo pill w…

This study is testing a self-help stress management program designed to help breast and gynecologic cancer patients in Vietnam cope with their diagnosis and treatment. About 285 patients will be randomly assigned to either try the new program or receive standard care. Researchers…

This study is testing whether wearing a special headband with embedded semiconductors can help reduce memory and thinking problems, often called 'chemo brain' or brain fog, in people with breast or gynecological cancers. Researchers will enroll 50 participants who have recently f…

This study is testing if using the Headspace mindfulness app can help women with endometrial or cervical cancer feel less stressed and have a better quality of life during their cancer treatment. Researchers want to see if practicing mindfulness with the app can also help reduce …

This study is testing whether a virtual mind-body wellness program can help cancer patients feel better during treatments like chemotherapy or radiation. The program offers online classes in things like meditation and yoga to help manage common side effects like severe fatigue. R…

This study is testing a new web application designed to help cancer patients report side effects from radiation therapy. Patients with breast, gynecologic, or urologic cancers will use the app weekly to log symptoms, which are sent securely to their doctors. The system uses a red…

This small pilot study is testing whether weekly activity coaching helps reduce fatigue in women undergoing pelvic radiation therapy for endometrial cancer. Sixteen participants will work with an exercise coach for ten weeks, set personal activity goals, and wear a Fitbit to trac…

This study is testing whether a mobile brain-training app can help reduce 'chemo brain'—the memory and thinking problems many people experience during cancer treatment. It will involve 64 women with gynecologic cancers who are undergoing chemotherapy. The goal is to see if regula…

This study is testing a new telehealth support program called BOLSTER for people with advanced gastrointestinal or gynecologic cancers who have complex care needs, like feeding tubes or drains. The program aims to improve patients' quality of life, ease symptoms, and reduce the b…

This study is testing if using cold wraps with compression on the hands and feet during chemotherapy is as good as cold wraps alone at reducing nerve pain, a common side effect. It involves 190 women with gynecologic cancers like ovarian or cervical cancer who are receiving a spe…

This small pilot study is testing whether a non-invasive brain stimulation technique can reduce nerve pain caused by chemotherapy. Researchers will enroll 19 female breast or gynecologic cancer survivors who developed persistent nerve pain after treatment. Participants will recei…

This study is testing a 7-day wellness retreat designed for women who have finished treatment for breast or gynecological cancers. It aims to see if the retreat is practical to study and if it helps improve survivors' quality of life, reduce stress, and ease symptoms like fatigue…

This study is testing whether listening to brief guided meditation sessions during radiation therapy can help reduce anxiety for people with breast or gynecological cancers. It will compare the anxiety levels of patients who receive the meditation sessions to those who receive st…

This study is testing if guarana, a plant-based supplement, can help reduce severe fatigue in people with certain cancers. It will enroll 86 adults with neuroendocrine tumors or gynecologic cancers who report significant fatigue. Participants will take guarana or a placebo for se…

This study is testing whether a personalized digital exercise program and online support group can help improve quality of life for people undergoing treatment for gynecologic cancers. Researchers will enroll 60 patients to see if the program is practical and acceptable, and whet…

This study aims to understand why cancer patients feel extreme fatigue and nerve pain during standard chemotherapy and radiation treatment. Researchers will observe 125 patients with various cancers, collecting blood and stool samples to look for biological markers linked to thes…

This study aims to find biological markers in blood and tissue samples from patients with advanced ovarian cancer. Researchers will collect samples from 510 participants to identify patterns that might predict how patients respond to treatments and how long they survive. The find…

This study aims to understand how bedside lung ultrasound can help monitor critically ill pregnant women and gynecological patients in intensive care. Researchers will observe 64 patients to see what lung problems ultrasound can detect and whether these findings relate to patient…

This study aims to collect detailed genetic information and health records from 25,000 adults who have cancer or are at risk of developing it. Researchers will analyze this data to better understand how cancer develops and to identify potential targets for future treatments. The …

This study aims to learn more about the genetic and immune system changes in gynecologic cancers like ovarian, uterine, and cervical cancer. Researchers will collect tumor tissue and blood samples from up to 1000 patients to analyze these changes. The goal is to understand how th…

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study aims to test a new method for collecting fluid from the uterus during gynecologic surgery. Researchers will analyze the cells and molecules in this fluid from 50 participants to better understand uterine health and disease. The goal is to gather knowledge, not to provi…

This study aims to understand how being frail—more vulnerable to health stressors—affects the recovery and quality of life of people with gynecologic cancers like ovarian or uterine cancer. Researchers will observe 500 newly diagnosed patients for one year to see if frailty is li…

This study aims to see if tracking tiny pieces of tumor DNA and other markers in the blood can help doctors better understand and monitor breast, digestive, and gynecologic cancers. Researchers will follow 1,000 patients to see if these blood tests can predict how well treatments…