New adaptive radiation aims to spare the gut in pancreatic cancer

NCT ID NCT05764720

Recruiting now Disease control Sponsor: Varian, a Siemens Healthineers Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial is testing a new type of radiation therapy that adapts daily to the exact shape and position of a pancreatic tumor. The goal is to deliver a high, tumor-killing dose while minimizing damage to nearby stomach and intestines. About 134 people with borderline resectable or locally advanced pancreatic cancer who have already had chemotherapy will take part. The main focus is on whether this approach lowers severe gastrointestinal side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Daily adaptive external beam radiation therapy
What this could lead to: If successful, this approach could offer a safer way to deliver high-dose radiation to pancreatic tumors, reducing severe gastrointestinal side effects while maintaining tumor control.
What could go wrong: This is a single-arm, non-randomized trial, so results may not be definitive. The technique is complex and may not be widely available. Side effects, though reduced, can still occur.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

UH Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35205, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Washington University, St. Louis
RECRUITING

St Louis, Missouri, 63130, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

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