New combo therapy targets tough pancreatic cancer in 20-Patient trial

NCT ID NCT05093231

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of two drugs, pembrolizumab and olaparib, in people with advanced pancreatic cancer that has spread to other parts of the body. To join, participants must have tumors with high mutation levels or specific DNA repair problems. The goal is to see if this treatment shrinks tumors and how safe it is.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Addenbrooke's Hospital

    RECRUITING

    Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Beatson West of Scotland Cancer Centre

    RECRUITING

    Glasgow, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • Clatterbridge Cancer Centre

    RECRUITING

    Liverpool, L7 8YA, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Derriford Hospital

    RECRUITING

    Plymouth, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • Epworth Healthcare

    RECRUITING

    Richmond, 3121, Australia

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Glan Clwyd Hospital

    RECRUITING

    Bodelwyddan, LL18 5UJ, United Kingdom

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Guy's and St Thomas' NHS Foundation Trust

    RECRUITING

    London, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • Milton Keynes University Hospital

    RECRUITING

    Milton Keynes, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • Monash Health

    RECRUITING

    Melbourne, 3168, Australia

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Norfolk and Norwich University Hospital

    RECRUITING

    Norwich, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • Nottingham University Hospitals NHS Foundation Trust

    RECRUITING

    Nottingham, United Kingdom

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Royal Free Hospital

    RECRUITING

    London, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • St James' University Hospital

    RECRUITING

    Leeds, United Kingdom

    Contact

    Contact Email: •••••@•••••

  • The Christie

    RECRUITING

    Manchester, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • University College London Hospitals NHS Foundation Trust

    RECRUITING

    London, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • University Hospitals Coventry and Warwickshire

    RECRUITING

    Coventry, United Kingdom

    Contact Email: •••••@•••••

    Contact

  • Velindre Cancer Centre

    RECRUITING

    Cardiff, CF14 2TL, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact