New combo therapy targets tough pancreatic cancer in 20-Patient trial
NCT ID NCT05093231
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a combination of two drugs, pembrolizumab and olaparib, in people with advanced pancreatic cancer that has spread to other parts of the body. To join, participants must have tumors with high mutation levels or specific DNA repair problems. The goal is to see if this treatment shrinks tumors and how safe it is.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Addenbrooke's Hospital
RECRUITINGCambridge, Cambridgeshire, CB2 0QQ, United Kingdom
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Beatson West of Scotland Cancer Centre
RECRUITINGGlasgow, United Kingdom
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Clatterbridge Cancer Centre
RECRUITINGLiverpool, L7 8YA, United Kingdom
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Derriford Hospital
RECRUITINGPlymouth, United Kingdom
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Epworth Healthcare
RECRUITINGRichmond, 3121, Australia
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Glan Clwyd Hospital
RECRUITINGBodelwyddan, LL18 5UJ, United Kingdom
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Guy's and St Thomas' NHS Foundation Trust
RECRUITINGLondon, United Kingdom
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Milton Keynes University Hospital
RECRUITINGMilton Keynes, United Kingdom
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Monash Health
RECRUITINGMelbourne, 3168, Australia
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Norfolk and Norwich University Hospital
RECRUITINGNorwich, United Kingdom
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Nottingham University Hospitals NHS Foundation Trust
RECRUITINGNottingham, United Kingdom
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Royal Free Hospital
RECRUITINGLondon, United Kingdom
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St James' University Hospital
RECRUITINGLeeds, United Kingdom
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The Christie
RECRUITINGManchester, United Kingdom
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University College London Hospitals NHS Foundation Trust
RECRUITINGLondon, United Kingdom
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University Hospitals Coventry and Warwickshire
RECRUITINGCoventry, United Kingdom
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Velindre Cancer Centre
RECRUITINGCardiff, CF14 2TL, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Two-Drug immune attack shrink Hard-to-Treat pancreatic tumors?
- Could a vaccine help fight Hard-to-Treat cancers?
- Blood and gut clues may flag pancreatic cancer risk early
- A high-tech camera may take the guesswork out of spotting a dangerous surgery complication
- MRI might reveal hidden pancreatic risks in obesity
- Can a new PET tracer light up hidden cancers?