Cambridge University Hospitals Nhs Foundation Trust

This study tests a combination of two drugs, pembrolizumab and olaparib, in people with advanced pancreatic cancer that has spread to other parts of the body. To join, participants must have tumors with high mutation levels or specific DNA repair problems. The goal is to see if t…

This phase 2 trial tests whether dapansutrile, a drug that targets inflammation, is safe and can reduce brain and body inflammation in people with early Parkinson's disease. 36 participants will take either the drug or a placebo daily for 6 months, with brain scans and spinal tap…

This study tests whether eating all meals within a 9-hour window each day for 12 weeks can improve insulin sensitivity and other heart health markers in 100 adults with obesity and prediabetes. Participants will be randomly assigned to either a 9-hour eating window or a 14-hour w…

This study tests whether powerful weight loss drugs (like semaglutide or tirzepatide) can lower blood pressure enough for young adults (ages 18-40) with obesity and early-stage hypertension to stop taking daily blood pressure pills. Sixty participants will either receive the weig…

This study is testing whether artificial intelligence can spot early signs of worsening heart failure by analyzing changes in a patient's voice, cough, and breathing sounds. Researchers will enroll 250 adults with chronic heart failure to record sounds and compare them with stand…

This study gives low-dose interleukin-2 to people who have had a heart attack and are scheduled for bypass surgery. Researchers want to see how the drug affects certain immune cells (regulatory T cells) inside heart tissue compared to blood. The goal is to understand whether thes…

This study looks at whether people with vascular Ehlers-Danlos syndrome (vEDS), a rare genetic disorder that weakens blood vessels, also have problems with how their body stores and uses fat. Researchers will compare 12-17 adults with vEDS to similar adults without the condition …