Cambridge University Hospitals Nhs Foundation Trust

This study tests whether powerful weight loss drugs (like semaglutide or tirzepatide) can lower blood pressure enough for young adults (ages 18-40) with obesity and mild hypertension to stop taking daily blood pressure pills. About 60 participants will either receive the weight l…

This study tests whether dapansutrile, a drug that targets inflammation, is safe and can reduce brain and body inflammation in people with early Parkinson's disease. 36 participants will take the drug or a placebo daily for 6 months, with brain scans and spinal fluid tests to mea…

This study tests whether combining two drugs, pembrolizumab and olaparib, can shrink tumors in people with advanced pancreatic cancer that has certain genetic changes (high tumor mutation burden or mismatch repair deficiency). About 20 adults who have had no more than one prior t…

This study tests whether artificial intelligence (AI) can detect early signs of fluid buildup in the lungs of people with heart failure by analyzing changes in their voice, cough, and breathing sounds. Researchers will enroll 250 adults with advanced heart failure to develop and …

This study tests whether restricting food intake to a 9-hour window each day, without changing what or how much you eat, can improve heart and metabolic health. Researchers will study 100 adults with obesity and prediabetes over 12 weeks. The goal is to see if this eating pattern…

This study looks at whether people with vascular Ehlers-Danlos syndrome (vEDS) have trouble storing and using fat, which could raise their risk for diabetes and heart disease. Researchers will compare 12-17 adults with vEDS to similar people without the condition using body scans…