New proton beam combo aims to shrink pancreatic tumors for surgery
NCT ID NCT02598349
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 2 trial tests whether a higher dose of proton radiation combined with the oral chemotherapy drug capecitabine can help people with unresectable pancreatic cancer live longer and possibly become candidates for surgery. The study enrolls 60 patients whose tumors cannot be removed or who are not healthy enough for surgery. The goal is to see if this intense local treatment improves survival and surgical rates compared to historical outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Proton radiation and capecitabine (oral chemotherapy)
What this could lead to
If successful, this approach could help more people with pancreatic cancer become eligible for surgery and extend survival.
What could go wrong
This is a small, early-phase trial with only 60 participants, so results may not apply broadly. The treatment involves intense radiation and chemotherapy, which can cause side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Inova Schar Cancer Institute
RECRUITINGFairfax, Virginia, 22031, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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McLaren Proton Therapy Center
RECRUITINGFlint, Michigan, 48532, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Northwestern Medicine Chicago Proton Center
RECRUITINGWarrenville, Illinois, 60555, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Florida Proton Therapy Institute
ACTIVE_NOT_RECRUITINGJacksonville, Florida, 32206, United States