PANCREATIC CANCER

This study tests whether combining an experimental drug (ZN-c3) with standard chemotherapy (gemcitabine) can help people with advanced pancreatic cancer that has stopped responding to initial treatment. The trial enrolled 12 participants and measures how many are alive without th…

This early-phase study tests a combination of two drugs (palbociclib and gedatolisib) in people with advanced lung, pancreatic, head & neck, or other solid tumors that have not responded to standard treatments. The goal is to find the safest dose and see if the drugs can slow can…

This study looks at how safe and effective the diabetes drug glipizide is for lowering blood sugar in people with pancreatic cancer. About 29 adults with active pancreatic cancer and high blood sugar will take glipizide, and their glucose levels will be measured before and after …

This early-phase study tests a vaccine targeting mutant KRAS proteins, combined with two immunotherapy drugs (nivolumab and ipilimumab), in 27 patients with resected pancreatic or colorectal cancer. The goal is to see if the combination is safe and boosts the immune system's abil…

This study tests a new drug called DZ-002 in adults with metastatic pancreatic cancer that has not spread through families. Participants have already completed at least 4 months of standard chemotherapy and their disease is stable. The drug is given weekly through an IV in 4-week…

This study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop advanced pancreatic cancer. It involves 3 newly diagnosed adults with inoperable or metastatic pancreatic cancer. The goal is to se…

This study tests whether giving chemotherapy both before and after surgery (perioperative) works better than giving it only after surgery (adjuvant) for people with pancreatic cancer that can be surgically removed. About 358 participants will receive a combination of standard che…

This study tests an experimental drug called 9-ING-41, which blocks a protein (GSK-3β) that helps cancers grow. It is given alone or with chemotherapy to 350 adults with advanced or hard-to-treat cancers like pancreatic, breast, lung, or bone cancer. The goal is to see if the dru…

This study tests the safety and effectiveness of combining three immunotherapy drugs (domvanalimab, zimberelimab, and APX005M) in people with metastatic pancreatic cancer that has spread to other parts of the body. The goal is to see if this combination can help control the cance…

This study tested a two-step treatment for people with pancreatic cancer that hasn't spread but can't be removed by surgery. First, patients received a stronger chemotherapy mix called modified FOLFIRINOX, followed by precise, high-dose radiation (SBRT). The goal was to see if th…

This early-phase study tests a mix of two immunotherapy drugs (nivolumab and ipilimumab), a vaccine targeting TGFβ-15, and targeted radiation for people with pancreatic cancer that has stopped responding to standard treatments. The goal is to see if this combination is safe and c…

This study tests a combination of two drugs, atezolizumab and cabozantinib, in 30 people with advanced pancreatic cancer that has spread and stopped responding to standard treatments. The goal is to see if the combo can shrink tumors or slow the disease. Researchers will also che…

This study tests an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors (like ovarian, breast, prostate, and lung cancer) that have stopped responding to standard treatments. The goal is to see if the drug is safe and tolerable when given alon…

This early-phase study tests an investigational cell therapy called P-MUC1C-ALLO1 in adults with advanced solid tumors (e.g., breast, ovarian, lung, pancreatic cancers) that have not responded to standard treatments. The main goals are to find a safe dose and check for early sign…

This study tests whether adding losartan (a blood pressure drug) and nivolumab (an immunotherapy) to standard chemotherapy and radiation can help shrink pancreatic tumors enough for successful surgery. About 168 people with localized pancreatic cancer that is borderline or locall…

This study tests a new combination of drugs (futibatinib plus standard immunotherapy) in adults with advanced esophageal or pancreatic cancer that cannot be removed by surgery. The goal is to see if the combination shrinks tumors and is safe. About 53 people will take part, and t…

This early-phase study tests a new treatment called EGFR-BATs for people with advanced pancreatic cancer that has not responded to standard chemotherapy. The treatment uses the patient's own immune cells, which are trained in a lab to better attack cancer cells. The main goal is …

This phase 3 study tests a new drug, daraxonrasib, against standard treatments in about 500 people with metastatic pancreatic cancer that has already been treated. The drug targets a specific genetic mutation (RAS) found in many pancreatic tumors. Researchers are measuring how lo…

This study planned to see if giving more chemotherapy after surgery could help people with pancreatic cancer live longer without the disease coming back. It was designed for patients who had already received chemo before surgery. However, the study was withdrawn before enrolling …

This study tested a new drug called ABTL0812 combined with standard chemotherapy for people with advanced pancreatic cancer that has spread. The goal was to see if the combination is safe and works better than chemo alone. The trial was suspended, so results are not yet available…

This study tests whether adding surufatinib to standard chemotherapy can help shrink pancreatic tumors enough for successful surgery. It involves 29 adults with locally advanced or borderline resectable pancreatic cancer who have not had prior treatment. The main goal is to see h…

This study looks at side effects of a 3-week radiation and chemotherapy treatment for people with pancreatic cancer that hasn't spread. It includes 103 adults with different stages of the disease. Researchers will also take blood samples to measure cancer DNA levels and see how t…

This study tests a new combination of two drugs (AGEN1423 and Botensilimab) with or without chemotherapy for people with advanced pancreatic cancer that has worsened after at least one prior treatment. The goal is to see if the combination can shrink tumors or slow the disease. A…

This study tests whether adding the drug Ampligen to standard treatment can help people with locally advanced pancreatic cancer live longer without their disease getting worse. About 90 adults who have already completed at least four months of first-line therapy without progressi…

This study is for people with pancreatic cancer that has spread to a major artery. It tests whether giving chemotherapy and radiation before surgery can make the tumor removable and improve survival. The trial involves 30 participants and tracks side effects, how many can have su…

This study tests a new type of radiation therapy called SCART for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to find the highest safe dose and see if it is feasible to deliver. About 24 adults aged 18 to 70 with good overall heal…

This study tests whether adding an immunotherapy combination (aldoxorubicin, N-803, and PD-L1 t-haNK) to standard chemotherapy helps people with advanced pancreatic cancer live longer without their cancer growing. About 328 adults with locally advanced or metastatic pancreatic ca…

This study offers continued treatment with ruxolitinib (alone or with other cancer therapy) to people with pancreatic, colorectal, breast, or lung cancer who were already benefiting from it in a previous Incyte-sponsored trial. Participants must have stable disease and be tolerat…

This study tests whether combining two immunotherapy drugs (nivolumab and ipilimumab) with radiation therapy can help control colorectal and pancreatic cancers that are either microsatellite stable (MSS) or MSI-high. About 84 adults with these cancers will receive the treatment. …

This study tests a new drug called zolbetuximab, which targets a protein (CLDN18.2) found in most pancreatic cancers. It is given along with standard chemotherapy to people whose pancreatic cancer has spread. The goal is to see if adding zolbetuximab helps people live longer and …

This study tests different combinations of immunotherapy drugs given before and after surgery for pancreatic cancer that can be removed. About 76 participants will receive these treatments to see if they help the immune system fight the cancer better. The goal is to improve how p…

This early-phase trial tests a new drug called TST001, an antibody that targets a protein (CLDN18.2) found on some cancer cells. It is being studied alone or with other treatments in about 150 people with advanced stomach, esophageal, or pancreatic cancers that have not responded…

This study tests whether adding a drug called ATRA (a form of vitamin A) to standard chemotherapy can help people with locally advanced pancreatic cancer live longer without their disease getting worse. About 170 participants will receive either chemo alone or chemo plus ATRA. Th…

This early-phase study tests whether adding two immune-boosting drugs (canakinumab and tislelizumab) to standard chemotherapy can safely shrink pancreatic tumors before surgery. Nine adults with resectable or borderline resectable pancreatic cancer will receive the combination. T…

This early-phase trial tests a new drug (TTI-101) combined with a precise type of radiation (SBRT) for people with pancreatic cancer that cannot be removed by surgery right away. The goal is to see if this combination is safe and can help keep the cancer from growing for longer. …

This study tests whether adding an immunotherapy drug (durvalumab) to standard chemotherapy before surgery is safe and practical for people with pancreatic cancer that can be removed. About 20 adults with early-stage pancreatic cancer will receive the combination treatment. The m…

This early-phase trial tests a new treatment called LB1908, which uses a patient's own immune cells (T-cells) engineered to recognize and attack cancer cells that have a protein called claudin 18.2 on their surface. The study includes adults with advanced stomach, gastroesophagea…

This study tests a drug called entrectinib in people with advanced solid tumors that have certain gene changes (NTRK, ROS1, or ALK). The drug aims to shrink or control the cancer by blocking these faulty genes. About 534 adults with various cancers, including lung, breast, and br…

This study gave a single patient with pancreatic cancer access to stem cells from a relative. The goal was to help control the cancer and ease symptoms like pain and fatigue. The treatment is no longer available.

This early-stage study tests whether a personalized cancer vaccine, made from a patient's own tumor, combined with an immunotherapy drug (atezolizumab) and chemotherapy, is safe after pancreatic cancer surgery. The 29 participants receive the vaccine and drugs to help their immun…

This study tests a new drug called NUV-1511 in people with advanced solid tumors that have not responded to other treatments. The trial has two parts: first, finding a safe dose, and second, checking if the drug shrinks tumors in specific cancers like breast, prostate, pancreatic…

This study tests whether a pancreatic enzyme replacement called pancrelipase can help maintain or improve body weight in people with metastatic pancreatic cancer. About 17 participants will receive either the enzyme or a placebo, and researchers will measure changes in body mass …

This study aimed to see if a person's own immune cells, modified in a lab to target specific cancer gene mutations, could prevent gastrointestinal cancers from coming back after standard treatment. It was designed for people with certain gene changes and blood markers suggesting …

This study tests a new approach for advanced pancreatic cancer that cannot be removed by surgery. Doctors place a special device that releases alpha radiation directly into the tumor. The goal is to see if this procedure is safe and possible for patients. About 37 adults with adv…

This early-phase study tests a new drug called LY4101174 in people with advanced or metastatic solid tumors, including bladder, breast, lung, and other cancers. The goal is to find a safe and effective dose and see if the drug can shrink tumors. About 490 participants will take p…

This early-phase study tests an experimental oral drug, HBI-2376, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have specific KRAS or EGFR gene mutations. The main goal is to find the safest dose and check for side effects. About 42 participan…

This early-phase trial tests a combination of two experimental drugs, defactinib and VS-6766, in people with advanced solid tumors that have not responded to standard treatments. The study includes patients with certain lung, ovarian, pancreatic, and endometrial cancers. The main…

This study tests whether adding an experimental drug called PEGPH20 to standard chemotherapy (gemcitabine and nab-paclitaxel) and a blood thinner (rivaroxaban) can help shrink advanced pancreatic cancer. PEGPH20 breaks down a substance called hyaluronan, which is often found in l…

This study was designed to check how well a new blood test can find hidden pancreatic cancer in people aged 50 and older who were recently diagnosed with type 2 diabetes. The plan was to enroll 10,000 participants and give them the test; if the test suggested cancer, they would g…

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. About 20 adults with various CEA-positive cancers will receive the injection and have scans over two days. The goal is to see if this method can dete…

This study aimed to compare two different needles used during endoscopy to collect tissue samples from solid masses in the pancreas and digestive tract. The goal was to see which needle provides a more accurate diagnosis of cancer or other conditions. The study was planned for ad…

This study aimed to test a new two-step PET imaging method to locate cancer cells that make a protein called CA19-9. It was designed for people with pancreatic, bladder, or gastrointestinal cancers. However, the study was withdrawn before enrolling any participants, so no results…

This study compares two procedures to relieve a blocked bile duct caused by cancer. About 120 people with pancreatic or bile duct cancer will be randomly assigned to get either a newer ultrasound-guided method or the standard ERCP procedure. The goal is to see which approach has …

This study tests whether using a FitBit and a mobile app can help people who have had surgery for stomach, liver, colon, or other GI cancers avoid going back to the hospital. About 107 adults who own a smartphone and are scheduled for surgery will either use the devices or get us…

This study tests a program that gives pancreatic cancer patients extra nutrition support from dietitians through remote visits and a fitness tracker. The goal is to see if patients find the program helpful and easy to use while on chemotherapy. About 80 adults with advanced pancr…

This study tests whether a supervised, video-based exercise program done at home during chemotherapy can help people with pancreatic cancer feel better and have better outcomes before surgery. About 58 adults with resectable pancreatic cancer will take part. The goal is to see if…

This study looks at whether starting palliative care early can improve quality of life and possibly survival for people with advanced pancreatic cancer. It involves 250 adults who are beginning their first cancer treatment. Researchers will measure changes in well-being and overa…

This study tests whether a remote nutrition coaching program is practical and well-liked by people with pancreatic cancer who are undergoing chemotherapy. About 40 participants will receive coaching and monitoring over 12 weeks. The goal is to see if this approach can help patien…

This study tests a program that lets cancer patients receive care at home through remote monitoring during chemotherapy or radiation. The goal is to see if this approach reduces hospital visits and emergency department stays. About 300 adults with certain cancers (like pancreatic…

This study tests whether regular exercise and behavioral skills training can improve physical fitness and quality of life in people with pancreatic cancer who are getting chemotherapy or radiation before surgery. About 128 participants will take part at MD Anderson. The main goal…

This early-phase study tests whether ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (unintended weight loss). About 28 partici…

This study tests a thin monitoring probe placed near the surgical site after pancreatic cancer surgery. The probe measures substances like lactic acid and glycerol to detect internal leaks early, before the patient becomes seriously ill. About 200 adults having this surgery will …

This study aims to create a large registry of nearly 7,000 pancreatic cancer patients by combining past records (2010-2022) and new data from over 800 patients (2023-2029). Researchers will use this real-world information to generate clinical evidence and explore how biomarkers r…

This study is creating a biobank—a collection of blood, tissue, and other samples—from 500 people with or suspected of having pancreatic cancer. The goal is to learn more about the disease, why it affects some groups more than others, and how to personalize care. Participants don…

This study looks at 271 people with pancreatic cancer to find genetic factors that may increase risk. Researchers will collect personal and family medical history and test for gene mutations. The goal is to build a tool that helps doctors assess hereditary risk and guide personal…

This study aims to create a test that predicts how well pancreatic cancer will respond to different chemotherapy treatments. Researchers will analyze tumor cells from blood and tissue samples of 74 participants with advanced pancreatic cancer. The goal is to help doctors choose t…

This study collects leftover tissue, blood, and other body fluids from 6,000 people with benign or malignant tumors of the soft tissue, gastrointestinal tract, or abdomen. Researchers will use these samples to learn more about what causes these cancers and how to better prevent, …

This study looks at whether a narrowed celiac artery (celiac axis stenosis) leads to more complications after surgery to remove part of the pancreas (pancreaticoduodenectomy). Researchers will follow 99 adults with pancreatic cancer who are having this surgery. The goal is to und…

This study examines a protein called DCAMKL-1, which may be a stem cell marker in pancreatic cancer. Researchers will measure its levels in 60 patients before and after standard treatment to see how it changes. The goal is to learn more about the disease, not to test a new treatm…

This study tests whether a special PET scan tracer called 18F-FAC can show how much of a standard chemotherapy drug gets into pancreatic tumors. About 30 adults with pancreatic cancer will get a PET scan before starting treatment. The goal is to learn more about drug uptake, not …

This study looks at whether a website and a genetic family navigator can help more family members of people with hereditary cancer get genetic testing. About 205 adults who have a known cancer gene mutation and their relatives will take part. The goal is to see if this approach m…

This study tests a new computer tool that uses CT scans to predict how blood flow will change during major abdominal surgery, such as for pancreatic cancer. The goal is to help surgeons plan operations without needing an invasive procedure called angiography, which carries risks.…

This study looks at 400 adults with metastatic pancreatic cancer to see if a new imaging method called radiomics can predict early who will not respond to chemotherapy. Researchers will analyze CT scans to find patterns linked to survival. The goal is to help doctors adjust treat…

This study collects leftover tissue and blood samples from people with known or suspected cancer who are already scheduled for surgery or biopsy. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. About 1,200 adults aged 1…

This study is being done to test whether receiving a dose of radiation that is higher than the standard dose, in combination with chemotherapy, improves the chance of becoming a candidate for surgery and improves the chance of extending the patient's life.