Immunotherapy cocktail takes on tough pancreatic cancer

NCT ID NCT04390399

Ongoing Disease control Sponsor: ImmunityBio, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether adding a mix of immune-boosting drugs and special immune cells to standard chemotherapy can help people with advanced pancreatic cancer live longer. About 328 participants will receive either chemo alone or chemo plus the immunotherapy combo. The study aims to see if the combo slows cancer growth and improves quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: combination of N-803 (immune booster), aldoxorubicin (chemotherapy), and PD-L1 t-haNK (immune cells) plus standard chemotherapy
What this could lead to: If successful, this could offer a more effective treatment option for advanced pancreatic cancer, potentially extending survival and improving quality of life.
What could go wrong: This is a mid-stage trial, so results are not yet proven. The combination may cause more side effects than standard chemo, and it may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC CANCER

Contacts and locations

Locations

Astera Cancer Care

East Brunswick, New Jersey, 08816, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Chan Soon-Shiong Institute for Medicine

El Segundo, California, 90245, United States
Hoag memorial Presbyterian Hospital

Newport Beach, California, 92663, United States

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