PANCREATIC CANCER

This study is testing a new drug called ANO31905, given along with standard chemotherapy, for people with advanced pancreatic cancer that has spread and cannot be removed by surgery. The main goals are to find a safe dose and see how well the combination works to shrink tumors. I…

This study is testing a two-step treatment for pancreatic cancer that is borderline or locally advanced, meaning it is difficult or impossible to remove with surgery right away. The goal is to see if giving two different combinations of chemotherapy drugs plus an immunotherapy dr…

This study is testing whether adding two oral drugs (defactinib and avutometinib) to a precise form of radiation therapy can better control advanced pancreatic cancer and keep it from getting worse. It will involve about 36 adults whose cancer has not progressed after initial che…

This study is testing whether adding a new antibody drug called FG-M108 to standard chemotherapy helps people with advanced pancreatic cancer live longer. It will involve 524 adults whose cancer has a specific protein marker called CLDN18.2 and who haven't had prior treatment for…

This study aims to find out if one of two different surgical connection techniques leads to fewer stomach emptying problems after pancreas removal surgery for cancer. It will involve 124 patients and compare recovery rates, complication risks, and quality of life over 90 days. Re…

This study aims to see if a new drug combination can help shrink pancreatic tumors before surgery. It will test an immunotherapy drug (adebrelimab) plus two standard chemotherapy drugs in about 30 patients. The goal is to see if this approach makes surgery more successful and imp…

This study is testing whether adding a focused ultrasound treatment (called IMD10) to standard chemotherapy helps people with borderline or locally advanced pancreatic cancer live longer. About 136 participants will be randomly assigned to receive either chemotherapy alone or che…

This early-stage study is testing the safety of a new, more precise type of radiation therapy for people with locally advanced pancreatic cancer that cannot be surgically removed. The technique, called SCART, aims to deliver a very high dose of radiation to the core of the tumor …

This study is testing a specialized surgery for adults with certain pancreatic or bile duct tumors who are at high risk for dangerous leaks after standard surgery. The procedure removes the entire pancreas to eliminate the tumor, then immediately transplants the patient's own ins…

This study is testing whether actively treating diabetes helps people with advanced pancreatic cancer live longer while they receive standard chemotherapy. It will enroll 210 adults whose pancreatic cancer has spread and who also have diabetes. Researchers believe that controllin…

This study is testing a new approach for locally advanced pancreatic cancer that cannot be removed by surgery. Doctors will place tiny radioactive metal tubes directly into the tumor to deliver radiation from the inside, while patients also take a chemotherapy pill. The main goal…

This early-stage study is testing a new treatment for people whose pancreatic cancer has come back or spread. It combines a type of cell therapy, where immune cells are engineered to attack cancer, with a daily pill. The main goals are to see if the treatment is safe and to find …

This study is testing whether combining a precise, high-dose radiation treatment with a specific chemotherapy regimen can better control locally advanced pancreatic cancer. It will involve 42 adults who have not had prior cancer treatment, comparing if giving the radiation early …

This early-stage study is testing if adding an experimental drug called NP137 to standard chemotherapy (FOLFIRINOX) before and after surgery can help control pancreatic cancer. The goal is to see if NP137 can change the tumor's behavior to make it less aggressive and potentially …

This study is testing whether a new drug called IBI343, when given with standard chemotherapy before surgery, can help control borderline resectable pancreatic cancer. It aims to shrink tumors so they can be surgically removed, followed by more chemotherapy after surgery. The tri…

This study is testing a new type of PET scan designed to improve the detection and staging of colorectal, gastric, and pancreatic cancers. It uses a special imaging agent that targets a protein called GPA33, which is often found on these cancer cells. The goal is to see if this n…

This study is testing a new online program designed to help people with pancreatic cancer manage stress and difficult symptoms like pain, fatigue, and poor sleep. The goal is to see if the program is practical for patients to use and if it improves their quality of life. Research…

This study is testing a new, faster process for delivering targeted radiation to relieve severe abdominal pain caused by pancreatic cancer. Instead of scheduling a new scan and waiting over a week for a treatment plan, doctors will use a patient's existing diagnostic scan to plan…

This study tests if a guided exercise program, tracked by a smartwatch, can help reduce the severe fatigue many people experience after finishing chemotherapy for cancer. It will involve 98 adults who have recently completed treatment for certain cancers. Researchers will compare…

This study is testing whether a 12-week supervised weight training program can help people with advanced pancreatic cancer who cannot have surgery. Researchers want to see if lifting weights twice a week helps patients keep their muscle mass, get stronger, and feel better during …

This study is testing whether a probiotic supplement called Clostridium butyricum CBM588 can help reduce diarrhea and other stomach problems after major pancreas surgery for cancer. About 158 patients will take either the probiotic or a placebo pill for three months after leaving…

This study aims to create a collection of tissue and blood samples from patients with liver, bile duct, and pancreatic cancers. Researchers will collect leftover samples from routine medical care without any additional procedures for participants. The collection will serve as a r…

This study is testing a digital app designed to help cancer patients understand their genetic test results. The goal is to see if using the app reduces patient distress and improves knowledge compared to receiving standard information from pamphlets or videos. The study will invo…

This study aims to collect and analyze tissue, blood, and fluid samples from people with suspected or confirmed cancers of the liver, bile ducts, or pancreas. Researchers will use these samples to understand the diseases better and to test new technologies, like advanced scopes a…

This study aims to track how well endoscopic ultrasound biopsies diagnose pancreatic and bile duct cancers in real-world hospital settings. It will follow 2,500 patients across specialized pancreas centers in Italy's Lombardy region to measure diagnostic accuracy, safety, and how…

This study aims to see if a new, detailed blood test can provide an early warning that pancreatic cancer is returning or spreading to the liver after surgery. Researchers will collect blood from 20 patients with operable pancreatic cancer and analyze it for tiny cancer cells and …