Zapping nerves with radiation may ease pancreatic cancer pain

This trial tests whether a short course of precisely targeted radiotherapy can safely reduce severe pain in people with advanced pancreatic cancer. The radiation is aimed at the coeliac plexus, a network of nerves in the abdomen that often causes pain when affected by the tumor. Participants receive Intensity Modulated Radiotherapy (IMRT), a technique that shapes radiation beams to spare healthy tissue. The main goal is to see if pain scores drop by at least 30% without increasing painkiller use. If successful, this approach could offer a non-invasive, widely available pain relief option across the UK.