PANCREATIC CANCER

This study tested whether a combination of a pancreatic cancer vaccine, an immunotherapy drug (pembrolizumab), and precise, high-dose radiation could help control locally advanced pancreatic cancer. It involved 58 patients whose cancer had not spread to distant organs but could n…

This study tested if adding a drug called paricalcitol (a form of vitamin D) to standard chemotherapy could help control advanced pancreatic cancer that had spread. It involved 27 adults whose cancer had not been treated before. The goal was to see if the vitamin D drug could slo…

This early-stage study tested whether combining two treatments is safe for people with advanced pancreatic cancer that hasn't spread. First, doctors used electricity to destroy tumor cells (irreversible electroporation), then gave an immunotherapy drug (pembrolizumab) to help the…

This study tested a new type of radiation therapy using carbon ions for people with pancreatic cancer that cannot be removed by surgery. It aimed to see if this advanced radiation is more effective than the current standard photon radiation at controlling the tumor and helping pa…

This study compared two surgical approaches for removing pancreatic, bile duct, and ampulla of Vater cancers: minimally invasive surgery (using small incisions and cameras) versus traditional open surgery. Researchers followed 320 patients aged 21-75 to see which method resulted …

This study aimed to find the highest safe dose of targeted radiation for pancreatic cancer patients. Researchers tested increasing radiation levels over five treatment sessions in 30 patients with inoperable or advanced pancreatic cancer. The goal was to determine the maximum dos…

This study tested whether combining the drugs cabozantinib and pembrolizumab could help control metastatic pancreatic cancer. It involved 21 patients whose cancer had worsened despite standard treatments. The main goal was to see if the combination could delay cancer growth and i…

This first-in-human study tested a new drug called Cabotamig in 33 adults with advanced gastrointestinal cancers that had stopped responding to standard treatments. The main goals were to check the drug's safety, see how the body processes it, and look for early signs that it mig…

This study tested if adding an immunotherapy drug (Anti-PD-1 antibody) to standard chemotherapy (modified-FOLFIRINOX) could help patients with borderline or locally advanced pancreatic cancer. It involved 392 participants who were randomly assigned to receive either the standard …

This early-stage study tested a new immunotherapy drug called CUE-102 in patients with advanced cancers that had returned or spread after standard treatments. The main goals were to find a safe dose and see how the body processes the drug. It involved 42 adults with specific type…

This early-phase trial tested a new cell therapy for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Researchers collected a patient's own immune cells from a tumor, used CRISPR gene editing to remove a molecular 'brake' (CISH), a…

This early-stage study aimed to find the safest and most effective dose of a three-drug combination for treating advanced pancreatic cancer. It involved 30 patients whose cancer had progressed after initial treatment. The main goal was to understand the side effects and determine…

This study tested an experimental therapy using a patient's own immune cells, specially grown in a lab to recognize and attack pancreatic cancer. It involved 37 adults whose cancer had returned, was not responding to standard treatments, or who were scheduled for surgery. The mai…

This early-stage trial tested a personalized vaccine designed to teach the immune system to attack a patient's specific pancreatic cancer. It involved 33 patients who had already received chemotherapy. The main goal was to check if the vaccine was safe. Researchers also measured …

This study tested a new drug called BMS-813160, given alone or combined with standard chemotherapy and/or an immunotherapy drug (nivolumab), in people with advanced colorectal or pancreatic cancer that had spread. The main goals were to find the safest dose, see how the body proc…

This early-phase trial tested a new personalized therapy for advanced gastrointestinal and other cancers driven by a specific genetic flaw called RAS G12D. Researchers collected a patient's own immune cells, genetically modified them in a lab to recognize and attack cancer cells …

This study tested a new combination of two drugs, NT-I7 and pembrolizumab, for people with advanced solid tumors that had returned or stopped responding to prior therapies. The main goals were to find a safe dose and see if the combination could shrink tumors in several hard-to-t…

This early-stage trial tested the safety of a new treatment called LOAd703 for pancreatic cancer. LOAd703 is a modified common cold virus designed to infect and kill cancer cells while also boosting the body's immune system. The study involved 51 patients who received the virus a…

This early-phase study tested whether combining a short, intense course of radiation with two immunotherapy drugs is safe for patients with advanced cancers that have spread. The trial involved 53 adults with metastatic melanoma, lung, breast, or pancreatic cancer who had tried o…

This study tested the safety and effectiveness of combining two drugs, pembrolizumab and lenvatinib, in people with advanced solid tumors that had stopped responding to standard treatments. It involved 611 participants with cancers like triple-negative breast, ovarian, gastric, c…

This study aimed to create and test a better way to diagnose pancreatic cysts and predict which ones might become cancerous. Researchers followed 477 adults with pancreatic cysts, using imaging scans and fluid tests to track changes over three years. The goal was to combine patie…

This large, completed study aimed to find out which of two commonly used antibiotics works better at preventing surgical site infections after a major pancreatic surgery called pancreatoduodenectomy. Nearly 1,000 adult patients scheduled for this surgery were randomly assigned to…

This small, early study tested a 12-week digital health coaching program delivered via a mobile app for people with pancreatic cancer and their caregivers. The main goal was to see if the program was easy to use, acceptable to participants, and practical to run. Researchers measu…

This study tested whether doctors could safely take small samples of a patient's pancreatic cancer tumor and grow miniature 3D versions (organoids) in the lab. Researchers then used these mini-tumors to test which chemotherapy drugs worked best against that specific patient's can…

This study looked at why some cancer patients who get a second opinion decide to stay with their original doctor, while others switch to the new doctor. Researchers reviewed the records of 236 patients with breast, pancreatic, or colorectal cancer who got a second opinion at the …

This study aimed to understand how the body changes after major surgery to remove pancreatic cancer. Researchers closely followed 44 patients before and after their operation, measuring things like weight, energy use, and blood markers. The goal was to gather detailed information…

This study tested two new methods to encourage people at higher risk for hereditary cancers to get recommended genetic testing. Over 800 participants in Michigan were randomly assigned to either use a special website, receive two coaching phone calls, or get standard information.…

This early-stage study tested a new imaging agent called NMK89 in patients with a specific type of pancreatic cancer. The main goal was to check if the agent is safe and to see how it travels and collects in the body using PET/CT scans. The study involved 10 patients to gather in…

This study tested a new method to collect and analyze cancer cells from the blood of pancreatic cancer patients. During a standard diagnostic procedure, doctors took an extra blood sample from a specific vein near the liver to see if the cancer cells found there could help predic…

This study aimed to understand if the types of bacteria in a person's gut are linked to whether their pancreatic cancer spreads to nearby lymph nodes. Researchers compared the gut bacteria and related chemicals in 55 patients who had pancreatic cancer with and without this type o…

This study analyzed global health data from 1990 to 2021 to understand how often pancreatic cancer and pancreatitis occur, cause death, and create disability in adults aged 70 and older across 204 countries. Researchers examined patterns by region, sex, and development level, and…

This study aimed to understand if measuring cancer DNA from different blood sources during pancreatic cancer surgery provides better information about the disease. Researchers collected blood from the arm and a specific liver vein, plus fluid from the abdomen, during surgery in 4…