PANCREATIC CANCER

This study tested a personalized vaccine made from each patient's unique cancer mutations (neoantigens) in people with pancreatic cancer. The vaccine was given after chemotherapy and before or after surgery to see if it is safe and boosts the immune system. 33 patients took part …

This trial tested a new treatment for people with advanced gastrointestinal cancers (like stomach, colon, or pancreatic cancer) that had spread and stopped responding to standard therapy. Doctors took immune cells from each patient's tumor, used CRISPR gene editing to remove a ge…

This study tested a combination of a pancreatic cancer vaccine (GVAX), an immunotherapy drug (pembrolizumab), and focused radiation (SBRT) in 58 people with locally advanced pancreatic cancer. The goal was to see if this mix could delay the cancer from spreading to other parts of…

This early-phase trial looked at combining a special type of radiation (hypofractionated radiotherapy) with two immunotherapy drugs (MEDI4736 and tremelimumab) for people with advanced melanoma, lung, breast, or pancreatic cancer that had spread. The main goal was to find the saf…

This early-phase study tested a new drug called cabotamig in 33 adults with advanced gastrointestinal cancers (like colon, stomach, liver, or pancreatic cancer) that had stopped responding to standard treatments. The drug works by attaching to a marker on cancer cells and helping…

This early-phase trial tested a new treatment for people with advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12D. Doctors took participants' own white blood cells, modified them in a lab to better recognize and attack…

This study tested a combination of four drugs (CRS-207, pembrolizumab, ipilimumab, and tadalafil) in 17 adults with metastatic pancreatic cancer that had worsened after at least one prior chemotherapy. The goal was to see if the treatment could shrink tumors and to check its safe…

This early-stage study tested a new drug called CUE-102 in 42 adults with certain advanced cancers (colorectal, stomach, pancreatic, or ovarian) that had returned or spread and were no longer responding to standard treatments. The goal was to find a safe dose and see if the drug …

This study tested whether adding two experimental drugs (TTX-030 and budigalimab) to standard chemotherapy helps people with metastatic pancreatic cancer live longer without their cancer growing. 194 adults who had not received prior treatment for their advanced cancer took part.…

This study tested a modified virus called LOAd703 in 51 people with pancreatic cancer. The virus is designed to infect and kill cancer cells while also boosting the immune system. It was given alongside standard chemotherapy, with or without an immunotherapy drug, to see if it is…

This early-phase study tested a powerful form of radiation called carbon ion therapy in 14 people with advanced pancreatic cancer that could not be removed by surgery. The main goal was to find the highest safe dose and watch for side effects within 90 days. Researchers also trac…

This study tested two common antibiotics, cefoxitin and piperacillin-tazobactam, to see which one better prevents surgical site infections after a complex pancreatic surgery called pancreatoduodenectomy. Nearly 1,000 adults having this surgery took part. The goal was to find the …

This early-phase study tested a custom-made yeast vaccine designed to teach the immune system to recognize and attack leftover cancer cells. Five adults with different solid tumors (like colorectal, breast, or lung cancer) who had already completed curative treatment received the…

This study tested a drug called niraparib in 32 people with advanced pancreatic cancer that has certain DNA repair problems. The goal was to see if the drug could slow down cancer growth. Participants had to have specific gene mutations, like BRCA or ATM, to join.

This study tested a combination of three chemotherapy drugs (paclitaxel, cisplatin, gemcitabine) in 34 people with metastatic pancreatic cancer that had not been treated before. If the cancer worsened, a fourth drug (paricalcitol) was added. The goal was to see how well the tumor…

This study tested a combination of two drugs (NT-I7 and pembrolizumab) in 215 adults with advanced solid tumors that had come back or stopped responding to standard treatments. The goal was to find a safe dose and see if the combo could shrink tumors. The study also looked at imm…

This early-stage study tested a new drug (BI 765049) alone or with another drug (ezabenlimab) in 21 Asian adults with advanced solid tumors like lung, stomach, or liver cancer. The goal was to find a safe dose and see if the drugs could shrink tumors. Participants received infusi…

This study tested whether adding an immunotherapy drug (anti-PD-1 antibody) to standard chemotherapy could help people with locally advanced or borderline resectable pancreatic cancer. The trial involved 392 participants and compared the combination treatment to chemotherapy alon…

This study tested an experimental drug called BMS-813160, given alone or with chemotherapy and/or the immunotherapy nivolumab, in 332 people with advanced colorectal or pancreatic cancer. The main goals were to check safety and side effects, and to see if the drug combination cou…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers that had stopped responding to standard treatments. The cancers included triple-negative breast, ovarian, gastric, colorectal, glioblastoma, biliary tract, and pancreat…

This study tested a powerful form of radiation called carbon ion therapy for people with pancreatic cancer that could not be removed by surgery. The goal was to see if this treatment could help patients live longer and control the disease better than standard radiation. Twenty-fi…

This study tested whether higher doses of a precise type of radiation (SBRT) could be safely given to people with pancreatic cancer that cannot be removed by surgery. The goal was to find the highest dose that does not cause severe side effects. Thirty patients took part in this …

This study tested whether adding a drug called paricalcitol (similar to vitamin D) to standard chemotherapy could help people with advanced pancreatic cancer that had stopped responding to initial treatment. 27 adults with metastatic pancreatic cancer took part. The goal was to s…

This early-phase study tested a combination of three drugs (gemcitabine, capecitabine, and erlotinib) in 30 people with advanced pancreatic cancer that had already been treated. The main goal was to find the safest dose and understand side effects. This is not a cure, but a way t…

This early-phase study tested the safety of combining a tumor-destroying procedure (IRE) with an immunotherapy drug (pembrolizumab) in people with locally advanced pancreatic cancer that could not be removed by surgery. Only 2 participants were enrolled. The goal was to see if th…

This study tested a combination of two drugs, cabozantinib and pembrolizumab, in 21 people with metastatic pancreatic cancer that had worsened after standard treatments. The goal was to see if the combo could slow cancer growth or shrink tumors. While not a cure, the approach aim…

This study tested a new experimental therapy using special immune cells (T cells) trained to attack five proteins found on pancreatic cancer cells. It included 37 patients whose cancer had returned, not gone away, or who could not have standard chemo. The main goals were to see i…

This study tested whether a more detailed endoscopic ultrasound could find cancer that has spread to lymph nodes in people with pancreatic cancer. 33 patients scheduled for surgery had an extended scope exam to check lymph nodes far from the main tumor. The goal was to see if thi…

This early-phase study tested a new imaging drug called NMK89 in 10 people with pancreatic cancer. The drug is designed to attach to a protein (MUC5AC) found on some pancreatic cancer cells and show up on PET scans. The main goal was to check safety and how well the imaging works…

This study looked at 477 adults with pancreatic cysts to find better ways to tell which cysts are harmless and which might become cancer. Researchers combined medical images, patient history, and fluid from the cysts to create a prediction model. The goal is to help doctors make …

This study tested a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to relieve pain in 19 people with advanced pancreatic cancer that could not be removed by surgery. The treatment uses heat to target nerves that send pain signals. The goal was to …

This study tested a 12-week digital health coaching program for people with pancreatic cancer and their caregivers. The goal was to see if the program was easy to use and helpful. 20 participants from Moffitt Cancer Center took part to share their feedback.

This study tested a program called STRONG that provides nutrition advice and supportive care remotely to adults with pancreatic cancer who are receiving chemotherapy. The goal was to see if the program was easy to use and if patients liked it. 50 people took part, and the study c…

This study looked at 40 adults with operable pancreatic cancer to see if measuring tumor DNA in blood (from a vein in the arm and a vein near the liver) and in belly fluid during surgery can help predict how the disease will progress. The goal was to understand if these DNA level…

This study tested a new method called the mass response biomarker to see if it can predict how well a cancer patient will respond to specific treatments. Researchers collected tumor cells from 72 adults with various cancers using fluid samples or tissue biopsies. The goal was to …

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to use a mobile website, receive two motivational coaching calls, o…

This study tested if it is safe and possible to collect a blood sample from the portal vein (a major vein near the liver) during a routine endoscopic ultrasound in 23 people with pancreatic cancer. The goal was to find and count circulating tumor cells (cancer cells that have bro…

This study looked at 44 adults who had surgery to remove a type of pancreatic tumor. The goal was to learn how the leftover part of the pancreas changes over time and how that affects nutrition and metabolism. Researchers measured things like energy use and body composition to fi…

This study looked at how well the drug T-DXd works compared to usual treatments for people with several types of advanced cancers that have high levels of a protein called HER2. Researchers used existing data from earlier trials and real-world medical records to compare outcomes.…

This study compared two surgical approaches for removing tumors in the pancreas and bile ducts: a less invasive (miniinvasive) method and traditional open surgery. Researchers looked at 320 adults aged 21-75 with resectable or borderline resectable cancers. The goal was to see wh…

This study tested a new way to collect pancreatic juice during an endoscopy by infusing vinegar into the duodenum. The goal was to see if this method could gather enough fluid to test for cancer markers. 75 adults with suspected pancreatic cancer took part. The approach aims to i…

This study looked at 236 adults with breast, pancreatic, or colorectal cancer who came to the University of Colorado for a second opinion. Researchers wanted to understand what factors, like patient background or disease type, influence whether someone decides to stay at the new …

This study examined data from over 720,000 older adults (70+) worldwide to understand how common pancreatic cancer and pancreatitis are, and how deadly they are. Researchers looked at trends from 1990 to 2021 and made projections to 2040. The goal was to identify patterns by regi…

This study looked at over 2,000 older adults (80+) with pancreatic cancer that hadn't spread, who were still in good health. It compared those who had surgery to remove the tumor with those who didn't, and also looked at the effect of chemotherapy after surgery. The goal was to h…

This study looked at 55 people with pancreatic cancer to see if the bacteria in their gut are linked to whether the cancer has spread to nearby lymph nodes. By analyzing stool samples, researchers identified specific gut bacteria and their byproducts that were different in patien…

This study looked at whether it is safe and possible to grow mini-tumors (organoids) from pancreatic cancer samples in the lab. Researchers took small tissue samples from 60 patients during surgery or a biopsy. They then tried to grow organoids and test different chemotherapy dru…