Radiation plus two immunotherapy drugs shows promise in advanced cancers

NCT ID NCT02639026

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-phase trial tested a new way to treat advanced cancers that have spread. It combined a special type of radiation with two immunotherapy drugs (MEDI4736 and tremelimumab) to see if the combination is safe and tolerable. The study included 53 adults with advanced melanoma, lung, breast, or pancreatic cancer who had not responded to standard treatments. The main goal was to find the best dose and schedule while monitoring side effects.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm malignant pancreatic neoplasm melanoma metastatic melanoma metastatic neoplasm Neoplasm Metastasis non-small cell lung carcinoma pancreatic adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Abramson Cancer Center of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States