New Two-Drug cocktail shows promise against tough cancers
NCT ID NCT04332653
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a combination of two drugs—NT-I7 (efineptakin alfa) and pembrolizumab (Keytruda)—in 215 people with advanced solid tumors that had stopped responding to treatment. The goal was to check safety, find the right dose, and see if the combo could shrink tumors. The trial included several cancer types, such as lung, breast, pancreatic, and ovarian cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NT-I7 (efineptakin alfa) and pembrolizumab (Keytruda)
- What this could lead to
- If it works, this combination could offer a new treatment option for several hard-to-treat cancers that have stopped responding to standard therapy.
- What could go wrong
- This is an early-phase study (1b/2a) with a small number of participants, so results may not apply to everyone. The drugs can cause serious side effects, and the combination may not work better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Mary Crowley Cancer Research
Dallas, Texas, 75230, United States
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Moffit Cancer Center
Tampa, Florida, 33612, United States
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Sarah Cannon Research Institute
Nashville, Tennessee, 37211, United States
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Washington University School of Medicine in St. Louis
St Louis, Missouri, 63110, United States
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