New drug combo aims to boost Chemotherapy's punch against pancreatic cancer

NCT ID NCT05355298

Ongoing Disease control Sponsor: Amplia Therapeutics Limited Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This trial tests whether adding an experimental drug called AMP945 to standard chemotherapy (nab-paclitaxel and gemcitabine) can improve tumor shrinkage in people with advanced pancreatic cancer that cannot be removed by surgery. The study has two parts: first, finding the best dose of AMP945, and then testing how well that dose works in a larger group. Participants must have metastatic or unresectable pancreatic cancer and have not received prior treatment for advanced disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AMP945 (a focal adhesion kinase inhibitor)
What this could lead to: If it works, this could improve how well chemotherapy shrinks tumors in people with advanced pancreatic cancer.
What could go wrong: This is an early-phase trial with a small number of participants, so results may not apply broadly. The drug may cause side effects or fail to improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic adenocarcinoma pancreatic ductal adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC CANCER PANCREATIC DUCTAL ADENOCARCINOMA PDAC

Contacts and locations

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Locations

Calvary Mater Newcastle

Waratah, New South Wales, 2298, Australia
Epworth Healthcare

Box Hill, Victoria, 3128, Australia
Epworth Healthcare

Richmond, Victoria, 3121, Australia
Gallipolli Medical Research Foundation

Greenslopes, Queensland, 4120, Australia
GenesisCare

St Leonards, New South Wales, 2065, Australia
Monash Health

Clayton, Victoria, 3168, Australia
National Cancer Centre

Gyeonggi-do, 10408, South Korea
Samsung Medical Centre

Seoul, 6351, South Korea
Seoul National University Bundang Hospital

Gyeonggi-do, 13620, South Korea
Seoul National University Hospital

Seoul, 3080, South Korea
Severence Hospital

Seoul, 03722, South Korea
Western Health

St Albans, Victoria, 3021, Australia
Westmead Hospital

Westmead, New South Wales, 2145, Australia

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