Cancer-Fighting T-Cell therapy trial for GI cancers withdrawn before start
NCT ID NCT06690281
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study aimed to test whether a person's own immune cells, modified in a lab to target specific cancer-related mutations (KRAS or TP53), could prevent advanced gastrointestinal cancers from coming back after standard treatment. Participants would have been randomly assigned to receive the cell therapy plus chemotherapy or to receive no treatment. However, the trial was withdrawn before any participants were enrolled, so no data were collected.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- modified T-cells (KRAS or TP53-targeting T-cell receptor transduced peripheral blood lymphocytes)
- What this could lead to
- If successful, this approach could help prevent gastrointestinal cancers from returning after standard treatment in people with specific genetic mutations.
- What could go wrong
- This trial was withdrawn before enrolling any participants, so no results are available. The therapy involves intensive chemotherapy and hospitalization, with risks of severe side effects from the cell infusion and chemotherapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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