New pill plus chemo takes on deadly pancreatic cancer in huge trial
NCT ID NCT07491445
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial tests a new drug called daraxonrasib, taken as a pill, either alone or with standard chemotherapy, against chemotherapy alone for people with metastatic pancreatic cancer. About 900 adults with confirmed pancreatic cancer that has spread will be randomly assigned to one of three groups. The goal is to see if the new drug helps people live longer or keeps the cancer from growing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
daraxonrasib (a RAS inhibitor drug taken as pills), gemcitabine (chemo given by IV), nab-paclitaxel (chemo given by IV)
What this could lead to
If it works, this could offer a new first-line treatment option for people with metastatic pancreatic cancer, potentially extending life or slowing tumor growth.
What could go wrong
This is a large phase 3 trial, but the drug is still investigational. It may not improve outcomes over standard chemo, and side effects from the combination could be significant.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Comprehensive Cancer Centers of Nevada
RECRUITINGHenderson, Nevada, 89052, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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H Lee Moffitt Cancer Center and Research Institute
RECRUITINGTampa, Florida, 33612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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SCRI - Texas Oncology Dallas
RECRUITINGDallas, Texas, 95246, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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SCRI Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Taylor Cancer Research Center
RECRUITINGMaumee, Ohio, 43537, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Cincinnati Cancer Center
RECRUITINGCincinnati, Ohio, 45219, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Mason Medical Center
RECRUITINGSeattle, Washington, 98101, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wakayama Medical University Hospital
RECRUITINGWakayama, 641-8510, Japan
Contact Phone: •••-•••-••••
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Yamaguchi University Hospital
RECRUITINGYamaguchi, 755-8505, Japan
Contact Phone: •••-•••-••••