HEAD AND NECK CANCER

This early-phase study tests a personalized cell therapy for people with certain advanced cancers (bladder, melanoma, head/neck, ovarian, lung, esophageal, stomach, sarcoma) that carry a protein called MAGE-A4. Patients' own immune cells are genetically modified to recognize and …

This study tests a way to make radiation therapy more precise for people with head and neck cancer. Doctors use a special scan (SPECT/CT) to see which lymph nodes drain fluid from the tumor. If the scan shows no drainage to the opposite side of the neck, that side can be safely l…

This study offers continued treatment with the cancer drug palbociclib to people who have already benefited from it in earlier Pfizer studies. It includes 35 adults with breast or head/neck cancer. The main goal is to monitor safety and track any serious side effects over time.

This study tests a new treatment for people whose head and neck cancer has come back. It combines a short course of radiation called QUAD SHOT with an immunotherapy drug called pembrolizumab. The goal is to see if this combination is safe and helps shrink tumors or improve qualit…

This study was designed to find a safe dose of the drug Torisel when added to standard chemotherapy and radiation for people with advanced head and neck cancer. The goal was to see if the combination could be given safely and help prevent the cancer from coming back. However, the…

This study looks at whether using home devices to check dehydration risk can lower emergency room visits and hospital stays for head and neck cancer patients. About 427 participants will either use the CYCORE sensor system at home or receive standard care. The goal is to see if t…

This study tests whether wrapping the spinal accessory nerve with a porcine (pig) tissue product during neck dissection for head and neck cancer can prevent shoulder problems after surgery. About 74 adults who have not had prior neck surgery or cancer treatment will be enrolled. …

This study tests an oral drug called APG-157 in 24 people with newly diagnosed head and neck cancer. The goal is to see if taking the drug before standard treatments like surgery can shrink tumors and improve outcomes. Researchers will measure tumor size changes using scans and c…

This study tests whether adding pembrolizumab, a drug that helps the immune system fight cancer, to standard surgery, radiation, and sometimes chemotherapy improves outcomes for people with head and neck cancer. About 96 participants who had surgery will receive pembrolizumab alo…

This early-stage study tests whether injecting the immunotherapy drug nivolumab directly into high-risk mouth lesions is safe and can shrink or eliminate them. 18 adults with precancerous mouth growths will receive the injections. The goal is to control these lesions and prevent …

This study tests a new drug, BT5528, given alone or with another drug (nivolumab) in people with advanced solid tumors that have high levels of a protein called EphA2. The main goals are to find safe doses and learn about side effects. The study also checks if the drug can shrink…

This study tests whether combining the drug tislelizumab with other experimental drugs can shrink tumors or slow cancer growth in people with advanced head and neck cancer that has come back or spread. About 160 adults whose cancer cannot be cured with local treatments will recei…

This study tests a three-drug combination called CACTUX (cisplatin, nab-paclitaxel, and cetuximab) in 74 adults with incurable head and neck cancer that has spread or come back. The goal is to see how well the treatment controls the disease and what side effects occur. Participan…

This study tests an experimental drug called INBRX-106, given alone or with the immunotherapy pembrolizumab (Keytruda), in people with advanced solid tumors (like lung, head and neck, melanoma, stomach, kidney, or bladder cancer) that have stopped responding to standard treatment…

This study tests whether adding two experimental drugs (INCAGN02385 and INCAGN02390) to the immunotherapy retifanlimab can help people with advanced head and neck cancer that has come back or spread. The trial includes 176 adults whose tumors have a specific marker (PD-L1 positiv…

This study tested whether adding the targeted drug Tarceva to two standard chemotherapy drugs (cisplatin and docetaxel) could shrink tumors in people with head and neck cancer that had spread or come back. Fifty adults with this advanced cancer took part. The goal was to see how …

This study tests whether a condensed, shorter course of radiation given before surgery is safe for people with head and neck cancer. It involves 12 adults with HPV-negative, advanced but removable tumors. The main goal is to see if this approach causes severe side effects or prev…

This study compares two ways of giving the chemotherapy drug cisplatin alongside standard radiation for people with locally advanced head and neck cancer. One group gets cisplatin every three weeks, the other gets it weekly. The goal is to see which schedule causes fewer severe s…

This study tests whether giving a short course of radiation plus an immunotherapy drug (pembrolizumab) before surgery can shrink advanced head and neck cancers. About 28 adults with stage III or IV HPV-negative head and neck cancer will receive this neoadjuvant treatment. The mai…

This early-phase study tests a new treatment called T-Plex for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to recognize and attack multiple cancer-related targets. Th…

This study tests whether adding experimental immune-boosting drugs (HB-201 and HB-202) to standard chemotherapy can shrink HPV16-positive throat tumors more effectively. The goal is to reduce the amount of radiation or chemotherapy needed afterward, potentially lowering side effe…

This study tests a new drug called NT219 combined with either pembrolizumab or cetuximab in people with head and neck cancer that has come back or spread. The goal is to see if the combination can shrink tumors. About 29 adults with incurable head and neck squamous cell carcinoma…

This study tested two immunotherapy drugs, nivolumab and ipilimumab, given before surgery to people with oral cavity squamous cell carcinoma. The goal was to see if the drugs could shrink tumors and be safe. 30 adults with stage T2 or higher tumors took part. The approach aims to…

This study looked at whether adding the drug cetuximab to radiation therapy after surgery helps people with advanced head and neck cancer live longer. About 700 patients took part. The main goal was to compare overall survival between those who got radiation alone and those who g…

This study tests whether a blood test that tracks tumor DNA can help doctors decide when to add short bursts of chemotherapy to standard immunotherapy for people with head and neck cancer that has returned or spread. About 30 adults will receive the immunotherapy drug pembrolizum…

This small early-phase study tests whether injecting methylene blue (a dye) directly into tumors can make radiation work better for people with head and neck cancer that has returned and is resistant to prior radiation. Ten participants will receive weekly tumor injections plus d…

This study looks at whether exercising the muscles used for coughing and swallowing can help head and neck cancer survivors who had radiation therapy. The goal is to reduce the risk of pneumonia caused by accidentally inhaling saliva. About 175 participants will be followed to se…

This early-phase study tests a personalized cell therapy (ADP-A2M4CD8) for people with advanced cancers like lung, ovarian, or melanoma that have a specific marker called MAGE-A4. The treatment uses the patient's own immune cells, modified to better attack the cancer, and is give…

This study tests whether giving the immunotherapy drug pembrolizumab for one year after standard treatment can delay cancer recurrence in 100 people with high-risk head and neck cancer. Participants receive either pembrolizumab or a placebo, and researchers track how long they li…

This study aimed to see if adding a low dose of radiation to a combination of targeted and immunotherapy drugs before surgery works better than using the drugs alone for head and neck cancer. The goal was to shrink tumors more effectively to improve surgical outcomes and potentia…

This study tests a new imaging agent called 111In-panitumumab to see if it can safely and accurately find cancer that has spread to lymph nodes in people with head and neck cancer. About 28 participants will receive the agent before surgery, and its performance will be compared t…

This study tests the safety of a new imaging drug called PARPi-FL in 12 people with head and neck cancer. The goal is to see if a PARPi-FL scan can take clear pictures of the cancer. Participants will receive the drug and be monitored for side effects. This is an early-phase stud…

This study tests if acupuncture can prevent dry mouth in people getting radiation for head and neck cancer. About 435 patients will receive one of two acupuncture approaches. The goal is to see which method better protects saliva production and improves quality of life.

This study tests if starting physiotherapy before swelling appears can prevent lymphedema in head and neck cancer survivors. Twenty adults who had surgery and radiation will be split into two groups: one gets daily home therapy with a compression device, the other gets standard c…

This study tests whether remote monitoring and personalized nutrition advice can reduce malnutrition and improve quality of life in people with head and neck cancer. About 125 adults with these cancers will receive tailored support throughout their treatment. The goal is to help …

This study tests whether a chatbot combined with continuous activity monitoring via a smartphone can help detect and manage symptoms early in people undergoing chemotherapy and radiation for lung, gastrointestinal, or head and neck cancers. The goal is to reduce unplanned hospita…

This study tests a self-management model designed to help people with head and neck cancer cope with emotional distress. 144 newly diagnosed patients were randomly assigned to either the self-help model or standard care. Trained nurses tracked their anxiety and depression levels …

This study compares proton beam radiation (PBRT) with standard photon radiation (IMRT) in 108 adults with certain head and neck cancers. The goal is to see if proton therapy causes fewer side effects, like severe mouth sores, by exposing less healthy tissue to radiation. Particip…

This study tests whether wrapping the nerve that controls the shoulder with a special protective material during neck cancer surgery can reduce pain and improve shoulder function. About 90 adults with head and neck cancer will take part. Researchers will check their shoulder func…

This study compares two approaches to treating lymphedema (swelling) in people who have had head and neck cancer. One group gets standard clinic-based therapy, while the other uses a home-based program with remote support. The goal is to see which method better reduces swelling, …

This early-phase study tests whether injecting a person's own bone marrow stem cells into their salivary glands can safely reduce dry mouth caused by radiation therapy for head and neck cancer. About 23 adults who finished radiation at least 2 years ago and have no active cancer …

This study tests a new way to deliver radiation therapy for head and neck cancer using an MRI machine built into the radiation device. The goal is to see if this approach can reduce severe dry mouth, a common and lasting side effect. About 49 adults with certain head and neck can…

This study tests a computer program called HN-STAR that helps people who finished treatment for head and neck cancer. Survivors use it to report symptoms and concerns before doctor visits, and doctors get recommendations to address them. The goal is to improve well-being and ensu…

This study was designed to see if using MRI scans to guide radiation therapy can better protect the salivary ducts and reduce dry mouth in people with oropharynx cancer. Dry mouth is a common and lasting side effect of radiation. The plan was to compare patient-reported dry mouth…

This study tests a new counseling approach called Acceptance and Commitment Therapy (ACT) to help people with certain cancers quit smoking. About 51 adults with head and neck, lung, breast, gastrointestinal, or genitourinary cancer who smoke at least one cigarette daily will rece…

This study aimed to find the best way to give tube feedings to head and neck cancer patients receiving chemoradiation. It compared three methods: bolus, gravity drip, and pump. The goal was to see which method helped patients maintain weight and tolerate feedings best. However, t…

This study tests a new, low-cost device to help people who have trouble opening their mouth fully after radiation treatment for head and neck cancer. The device is a jaw stretcher with sensors that measure pressure and how wide the mouth opens, giving real-time feedback. About 35…

This study tests a program that lets cancer patients receive care at home through remote monitoring during chemotherapy or radiation. The goal is to see if this approach reduces hospital visits and emergency department stays. About 300 adults with certain cancers (like pancreatic…

This study tests an online program called Empowered Survivor, designed to help people who have had oral or throat cancer feel more confident managing their health after treatment. About 643 cancer-free survivors will use either the Empowered Survivor tool or a free online program…

This study is testing whether a yoga program done by patients and their family caregivers together can help improve quality of life during radiation therapy for head and neck cancer. It aims to see if the program is practical to run and if it helps with fatigue, sleep, mood, and …

This study was designed to see if automatic software could accurately outline tumors and healthy organs during radiation therapy for head and neck cancer. It planned to enroll adults with advanced head and neck cancer and compare manual and automatic contouring methods. However, …

This study looks at how proton beam therapy (PBT) affects the teeth and jaws of children treated for head and neck cancer. Researchers will survey survivors and review dental records to understand what side effects occur and how often. The goal is to gather information to create …

This study looks at whether giving doctors information about a patient's genes can help them personalize chemotherapy doses and reduce severe side effects. About 860 adults with certain cancers (like breast, gastrointestinal, or head and neck) will be randomly assigned to have th…

This study tests a new imaging system called HyperSight that takes clearer, faster 3D scans during radiation therapy for cancer. The goal is to see if these scans are good enough to help doctors plan treatment more accurately. About 40 adults with head and neck, breast, lung, upp…

This study aims to see if extra MRIs and blood biomarker tests can help predict how head and neck tumors change during radiation therapy. Up to 100 people (80 patients and 20 healthy volunteers) will take part. The research focuses on measuring tumor growth and blood markers over…

This study aimed to develop a standardized teaching program to help caregivers feel confident managing a loved one's tracheostomy after head and neck cancer surgery. It planned to enroll patients and their family caregivers, but the study was withdrawn before any participants wer…

This study looks at how tumors evolve when patients with advanced head and neck cancer or melanoma receive immune checkpoint inhibitors. Researchers collect blood samples and tumor biopsies to track genetic changes in the cancer over time. The goal is to understand how tumors ada…

This study explores whether creating a virtual 3D map of a patient's tumor can help doctors plan radiation therapy more accurately for head and neck cancer. About 13 adults who have had surgery for head and neck cancer will participate. Researchers will compare standard radiation…

This study looks at how a protein called AXL in head and neck tumors responds to a combination of two drugs, imatinib and cetuximab, given before standard treatment like surgery or radiation. About 15 adults with head and neck cancer will receive the drugs for a short time, then …

This study aimed to see if a personalized online education program could help patients and their caregivers feel more prepared before and after major head and neck surgery, and reduce trips back to the hospital. The program was designed for adults undergoing free flap surgery or …

This study aims to understand head and neck cancers that occur during pregnancy or within a year after giving birth. Researchers will look at virus exposure (HPV and EBV), pregnancy complications, and tumor types in about 14 women. The goal is to gather information, not to test a…

This study tests a new program to help head and neck cancer patients who feel depressed. It looks at whether the program is easy to use and if it helps patients follow their swallowing exercises and dental care. About 185 adults with stage I-IV cancer take part. The goal is to se…

This study follows 350 head and neck cancer survivors about 7 years after radiation therapy to see how their teeth, gums, and jawbone are doing. Researchers will check for cavities, gum disease, tooth loss, bone damage, and dry mouth. The goal is to understand long-term dental pr…

This study looks at whether radiation therapy for head and neck cancer affects thinking skills like memory and focus. About 54 newly diagnosed patients will take thinking tests and fill out questionnaires three times over one year. The goal is simply to gather information, not to…

This study is testing whether artificial intelligence can predict how well head and neck cancer patients will respond to radiation therapy and whether they will have side effects. Researchers will use scans (CT, MRI, PET) to extract features and build machine learning models. The…

This study looks at whether special MRI scans can predict how well head and neck cancer patients will respond to surgery or chemo-radiation. About 272 adults with head and neck cancer will get these advanced scans before and early during treatment. The goal is to find markers tha…

This study was designed to see if a mobile health app helps patients with recurrent head and neck or gynecologic cancers track their symptoms and quality of life. Researchers planned to ask patients about their experience using the app and whether they found it easy and useful. T…

This study aimed to map the glossopharyngeal nerve and test if electrical stimulation could open the airway in people with head and neck cancer and sleep apnea. It was withdrawn before enrolling anyone, so no results are available. The goal was to better understand nerve anatomy …

This study looks at whether using a fluid injection called tumescence helps skin grafts heal better after head and neck cancer surgery. About 58 adults having this surgery will be randomly assigned to get either tumescence or standard care. The main goal is to see if tumescence l…

This study screens up to 1,150 adults with advanced solid tumors (like head and neck, cervical, or lung cancer) to check their genetic markers and tumor features. The goal is to find who might qualify for future experimental T-cell therapies that target specific cancer antigens. …