HEAD AND NECK CANCER

This study is testing if injecting a special saltwater solution (tumescence) into the thigh before taking a skin graft improves how well the graft heals on a patient's arm or leg after head and neck cancer surgery. Researchers are comparing this technique to the current standard …

This early-stage study is testing the safety of a much shorter, more intense course of radiation given before surgery for certain head and neck cancers. The goal is to see if delivering the radiation in just 5 to 10 visits over 1-2 weeks is as safe as the standard 30-visit schedu…

This early safety study is testing whether injecting a blue dye called methylene blue directly into tumors can make radiation therapy more effective for head and neck cancer that has come back after previous radiation. Ten patients will receive weekly injections along with six we…

This study is testing whether using MRI scans during radiation treatment can help doctors better target head and neck cancer tumors while reducing damage to nearby healthy organs. The trial involves 25 patients and aims to personalize the radiation dose based on how the tumor res…

This study compares three different immunotherapy approaches for people with advanced head and neck cancer that has returned or spread. Researchers want to see if combining two or three immunotherapy drugs works better than using just one drug alone. The trial involves 176 partic…

This early-stage trial is testing a new drug called INBRX-106, both by itself and combined with an existing immunotherapy (pembrolizumab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how …

This study is testing if a new lozenge called APG-157 can safely shrink head and neck tumors before patients start their main cancer treatment, like surgery or radiation. Researchers want to see if reducing the tumor size first leads to better outcomes. The study involves 24 newl…

This study is testing whether using simple devices at home to check for early signs of dehydration can help patients with head and neck cancer avoid trips to the emergency room or hospital. About 427 patients are comparing standard care to using a special monitoring system called…

This study is testing whether a breathing exercise device can help head and neck cancer survivors who have had radiation therapy. The device strengthens muscles used for coughing and swallowing, which may reduce the risk of pneumonia caused by accidentally inhaling saliva. About …

This early-stage trial is testing the safety of a new treatment called ADP-A2M4CD8, which uses a patient's own modified immune cells to fight cancer. The study will enroll 120 adults with one of nine advanced cancers who have specific genetic markers. Researchers will give the ce…

This study is testing a computer program called HN-STAR, designed to help people who have finished treatment for head and neck cancer. Survivors use the program to report their symptoms and concerns before a doctor's visit, which helps their care team create a personalized follow…

This study is testing a more precise way to deliver radiation to patients with head and neck cancer. Doctors use a special scan to map which lymph nodes are at risk, aiming to avoid radiating healthy areas on the opposite side of the neck. The goal is to control the cancer while …

This study aimed to see if adding a drug called temsirolimus (Torisel) to standard chemotherapy and radiation was safe for people with advanced head and neck cancer. It was designed to find the highest dose of temsirolimus that could be given safely alongside the usual treatments…

This is an early safety study to see if injecting a drug called nivolumab directly into high-risk mouth lesions is safe and tolerable. The goal is to see if this local treatment can shrink or eliminate these precancerous spots to prevent them from developing into head and neck ca…

This study compares two radiation treatments for head and neck cancer to see which causes fewer side effects. Researchers are testing whether proton beam radiation causes less damage to healthy tissue than traditional photon radiation. The main goal is to see if patients receivin…

This study is testing whether an immunotherapy drug called tislelizumab, either alone or combined with other experimental drugs, can help control advanced head and neck cancer that has returned or spread. About 160 patients who have not yet received treatment for their advanced c…

This study allows patients with breast or head/neck cancer who benefited from palbociclib in previous Pfizer trials to continue receiving the medication. The main goal is to monitor the long-term safety of the treatment in these patients. Participants will be followed to track an…

This early-stage study is testing a new drug called BT5528 in people with advanced solid tumors that have spread or returned. The main goals are to find a safe dose, understand the side effects, and see if the drug shows early signs of helping to control cancers like ovarian, lun…

This study planned to see if adding a low dose of radiation to a combination of targeted and immunotherapy drugs works better than the drugs alone when given before surgery for head and neck cancer. The goal was to shrink tumors more effectively to improve surgical outcomes and l…

This large study aimed to see if adding a targeted drug called cetuximab to standard radiation therapy helps patients live longer after surgery for advanced head and neck cancer. It involved 702 patients who had their tumors removed but were at intermediate risk of the cancer com…

This study is testing two different schedules for giving the chemotherapy drug cisplatin alongside radiation for head and neck cancer. It aims to see if getting the drug once every three weeks causes fewer severe side effects than getting it weekly, while still being effective at…

This study is testing whether a drug called pembrolizumab can help prevent cancer from returning in people with high-risk head and neck cancer who have already finished their main treatment. About 100 patients will receive either the drug or a placebo for one year to see if it im…

This early-stage study is testing the safety of a new, personalized cell therapy for people with advanced solid tumors that have stopped responding to standard treatments. Doctors collect a patient's own immune cells, genetically modify them to better recognize and attack their s…

This study tests whether remote monitoring and tailored nutrition support can help control malnutrition in head and neck cancer patients. Researchers are comparing standard care to an app-based program that tracks nutrition from hospital to home. The goal is to reduce malnutritio…

This study is testing whether giving immunotherapy drugs before standard surgery can help shrink oral cavity cancer tumors. It involves about 30 adults with a specific type of head and neck cancer who are scheduled for surgery. Researchers want to see if the drugs, nivolumab alon…

This study is testing a combination of three cancer drugs (cisplatin, nab-paclitaxel, and cetuximab, called CACTUX) for people with incurable head and neck cancer that has spread or returned. The main goal is to see if this combination can help control the cancer for a longer tim…

This study is testing if personalized text messages can help head and neck cancer survivors quit drinking alcohol. Drinking increases the risk of the cancer returning. Researchers will enroll 138 survivors and send some of them supportive text messages for three months to see if …

This early-stage study aims to test the safety of a new radioactive imaging agent (111In-panitumumab) designed to help doctors see if head and neck cancer has spread to nearby lymph nodes. Researchers will compare this new method, given by injection before surgery, to the standar…

This study is testing a new imaging drug called PARPi-FL to see if it can help doctors get clearer pictures of head and neck cancer. It involves 12 adult patients with confirmed cancer who are scheduled for surgery at Memorial Sloan Kettering. The main goal is to check the safety…

This study is testing a new imaging technology called HyperSight to see if it can take clearer pictures during radiation therapy. The goal is to help doctors more accurately target cancer cells while better protecting healthy tissue. About 40 adults with head and neck, breast, lu…

This study is testing whether starting a simple home therapy early can prevent painful facial and neck swelling (lymphedema) in people who have been treated for head and neck cancer. Researchers will use a special imaging scan to spot early signs of swelling and then have one gro…

This study is testing whether acupuncture can prevent severe dry mouth, a common and painful side effect, in people receiving radiation treatment for head and neck cancer. About 435 participants will be randomly assigned to receive one of two different acupuncture approaches or s…

This early-stage study is testing whether injecting a person's own bone marrow stem cells into their salivary glands is safe and might help relieve severe, persistent dry mouth caused by radiation treatment for head and neck cancer. Up to 23 participants who are at least 2 years …

This study aims to find the best counseling method to help cancer patients quit smoking. It compares a newer therapy (Acceptance and Commitment Therapy) against standard counseling, with both groups also receiving a quit-smoking medication. The goal is to see which approach is mo…

This study tested a new self-management rehabilitation program designed to help people with head and neck cancer. It compared this new program to standard rehabilitation care to see which was better at reducing anxiety, depression, and improving quality of life. Researchers measu…

This study aimed to test whether using detailed MRI scans to guide radiation treatment could help reduce severe, long-lasting dry mouth in people receiving radiation for throat cancer. Researchers planned to compare a new approach that specifically avoids damaging key saliva duct…

This study is comparing two online programs designed to help people who have finished treatment for oral or throat cancer. It aims to see if a new tool called 'Empowered Survivor' helps people feel more confident managing their health, better prepared for life after cancer, and i…

This study is testing a new, low-cost device designed to help people who have trouble opening their mouth after radiation treatment for head and neck cancer. The device is like a jaw-stretching tool with sensors that give feedback, aiming to make exercises more effective. Researc…

This study aimed to test if a personalized online education program could help patients and their caregivers feel more prepared for major head and neck cancer surgery. It planned to see if the program improved patient satisfaction and reduced the need for unplanned hospital visit…

This study is testing whether doing yoga together can help head and neck cancer patients and their family caregivers feel better during radiation therapy. About 236 patient-caregiver pairs will be assigned to either do partner yoga sessions or just fill out questionnaires. Resear…

This study is testing if a protective wrap made from pig tissue can help a shoulder nerve heal better after surgery to remove lymph nodes for head and neck cancer. The goal is to reduce post-surgery shoulder pain, weakness, and difficulty moving the arm. Researchers will measure …

This study tests whether weekly phone counseling sessions can help reduce depression in people undergoing radiation treatment for head and neck cancer. Researchers want to see if easing depression helps patients stick better to important swallowing exercises and dental care routi…

This study is testing whether special types of MRI scans taken before and during treatment can predict how well patients with head and neck cancer will respond to therapy. Researchers are looking at 272 patients to see if these advanced scans can identify which patients are likel…

This study aimed to learn more about a specific nerve in the throat (the glossopharyngeal nerve) and see if electrically stimulating it during surgery could help keep the airway open. It planned to involve adults with sleep apnea who were already scheduled for surgery to remove a…

This study aimed to test a smartphone app for patients with recurrent head, neck, or gynecologic cancers. The goal was to see if the app was easy to use and helpful for patients to report their daily symptoms, quality of life, and any barriers to their care during treatment. The …

This study aimed to create and test a better training program for family members who care for head and neck cancer patients with a tracheostomy (a breathing tube in the neck). It planned to measure if the training made caregivers feel more confident and prepared, and if it led to…

This study is screening cancer patients to collect genetic information from their tumors and saliva. Researchers will analyze this data to identify patients who might qualify for future clinical trials testing new cellular therapies. No treatment is provided in this study—it's pu…

This study aims to understand the out-of-pocket costs and financial strain experienced by people undergoing treatment for head and neck cancer. Researchers will follow 60 patients to see how these costs impact their quality of life and influence their treatment decisions. The stu…

This study aims to understand how advanced cancers like melanoma and head/neck cancer change and evolve when treated with immunotherapy drugs. Researchers will collect tumor biopsies and blood samples from a small group of patients at different points during their treatment. The …

This study aims to learn if taking extra MRI scans and blood tests during radiation treatment can help doctors predict how a head and neck tumor will change. Researchers will track tumor size and look for biomarkers in the blood of about 80 cancer patients and 20 healthy voluntee…

This study aims to understand if radiation therapy for head and neck cancer affects memory, focus, and other thinking skills. Researchers will follow 54 recently diagnosed patients for one year, asking them to complete thinking tests and questionnaires at three different times. T…

This study follows head and neck cancer survivors to understand the long-term dental effects of their radiation treatment. Researchers are checking in with about 350 people from a previous study roughly 7 years after their radiation therapy started. They are measuring problems li…

This study aims to collect information about head and neck cancers that are diagnosed during pregnancy or within a year after giving birth. It involves women who were diagnosed with these cancers between 2010 and the study start. The goal is to better understand the characteristi…

This is a small, early-stage study to learn how head and neck cancer tumors respond to a short course of two drugs, imatinib and cetuximab, given in the time between diagnosis and the start of standard treatment like surgery or radiation. Researchers will take small tumor samples…

This study aims to understand how often proton beam therapy, a cancer treatment, causes side effects to the teeth and jaws in children and teenagers treated for head and neck cancer. Researchers will survey survivors, review their dental records, and analyze their past radiation …

This study aims to gather information to design a better, more manageable care plan for people who have both cancer and COPD (a chronic lung disease). Researchers will interview 100 patients and healthcare providers to understand the challenges of managing both conditions. The go…