New drug shows promise in shrinking head and neck tumors before surgery

NCT ID NCT05312710

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests an oral drug called APG-157 given before standard treatment (surgery or radiation) for people with newly diagnosed head and neck cancer. The goal is to see if the drug can shrink tumors and improve outcomes. About 24 adults with early to advanced stage cancer will take the drug for a short time, then have scans and biopsies to measure changes.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms Mouth Neoplasms oral cavity squamous cell carcinoma oropharynx cancer oropharynx squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Miami Sylvester Comprehensive Cancer Center

    Miami, Florida, 33136, United States

  • VAGLAHS, West Los Angeles

    Los Angeles, California, 90073, United States