Experimental vaccine plus chemo aims to shrink HPV throat tumors and reduce radiation
NCT ID NCT05108870
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests two experimental vaccines (HB-201 and HB-202) given with standard chemotherapy drugs (carboplatin and paclitaxel) to people with HPV16-positive oropharyngeal cancer. The goal is to see if this combination can shrink tumors enough to allow less intensive follow-up treatment, such as robotic surgery or lower doses of radiation and chemo. About 35 participants will be followed for two years to assess safety and tumor response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HB-201 and HB-202 (TheraT® vectors) plus carboplatin and paclitaxel chemotherapy
- What this could lead to
- If successful, this approach could shrink tumors more effectively and allow some patients to avoid high-dose radiation or extensive surgery, reducing long-term side effects.
- What could go wrong
- This is an early-phase trial with only 35 participants, so results may not apply broadly. The experimental vaccines are not yet FDA-approved, and side effects from combining them with chemotherapy are still being studied.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Chicago
Chicago, Illinois, 60637, United States
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