HEAD AND NECK CANCER

This study aims to see if giving radiation therapy (either standard X-ray or proton therapy) along with an immunotherapy drug (pembrolizumab) before surgery is safe and more effective for people whose head and neck cancer has come back. The research will involve about 40 adults w…

This study is testing whether doctors can safely lower radiation doses for people with HPV-positive throat cancer to reduce side effects while still keeping the cancer under control. It will enroll 132 adults who are having either surgery followed by radiation or radiation as the…

This study is testing a more personalized approach to radiation therapy given after surgery for head and neck cancer. The goal is to see if doctors can safely target radiation to smaller, specific areas to reduce common and severe side effects, without increasing the risk of the …

This study is testing whether giving two drugs, XL-092 and pembrolizumab (Keytruda), before surgery can better shrink tumors in people with a specific type of oral cavity cancer that is not linked to HPV. The goal is to see if this combination leads to more patients having little…

This study is for adults with HPV-positive head and neck cancer who have finished their main treatment but still have tiny traces of cancer in their blood. It will test if adding a new drug called fianlimab to an existing immunotherapy (cemiplimab) works better than the single dr…

This early-stage study is testing whether adding an experimental drug called decitabine can make an approved immunotherapy (nivolumab) work better against recurrent or spreading head and neck cancer. The main goals are to find the safest dose of the combination and see how it aff…

This trial is testing whether a special scan can help doctors target radiation more precisely for throat cancer. Currently, patients receive radiation to both sides of the neck, which causes more side effects. The study will see if using this scan to guide treatment to only the a…

This study is testing whether adding an immunotherapy drug called toripalimab to standard chemotherapy is safe and effective for people with a specific type of advanced head and neck cancer. It will involve about 26 adults whose cancer has not spread to distant organs. The main g…

This study is testing if a type of CT scan called Dual-Energy CT (DECT) can work as well as MRI scans for planning radiation therapy. Doctors need very clear pictures to map out tumors and avoid damaging healthy organs during radiation. The study will enroll 80 patients with canc…

This study aims to find the best way to prevent or reduce severe skin rashes in head and neck cancer patients receiving a specific type of radiation therapy called TomoTherapy. Researchers will compare two different, easy-to-use skin dressings to see which one better protects the…

This study is testing whether a proactive, nurse-led program to manage symptoms can help people with head and neck cancer complete their planned radiation therapy without unplanned breaks. It will compare this new approach to standard care in 170 patients. The main goal is to see…

This study is testing whether a special dental care program can help people who have survived head and neck cancer. It will see if regular visits to a dental hygienist every three months can reduce long-term mouth problems like dry mouth, pain, and tooth decay, and improve qualit…

This study is testing if a new technique using a patient's own skin cells (RECELL®) can lead to a better skin color match after reconstructive surgery for head and neck cancer. Researchers will compare the new method to two standard skin grafting techniques in 20 patients. The ma…

This study follows head and neck cancer survivors who receive custom facial prostheses to restore their appearance and function. Researchers will measure how well patients can chew, swallow, and speak before and after getting their prosthesis, and track changes in their quality o…

This study is testing if a drug called Pedmark® can protect hearing in adults receiving cisplatin chemotherapy, a common cancer treatment that often causes permanent hearing loss. The drug is already approved for children, but this trial will see if it's safe and effective for ad…