HEAD AND NECK CANCER

This study tests whether adding fianlimab to the standard drug cemiplimab can better prevent cancer from returning in people with HPV-positive head and neck cancer who have tiny amounts of cancer still detectable after initial treatment. About 68 adults will receive either cemipl…

This study tests whether extra dental support for head and neck cancer survivors can prevent or reduce late side effects like tooth loss, jaw stiffness, and cavities. About 300 adults who finished cancer treatment will receive an oral care program every three months for three yea…

This study tests a combination of the immunotherapy drug toripalimab with two chemotherapy drugs (cisplatin and docetaxel) as an initial treatment for people with advanced head and neck cancer that has a specific marker (CPS-positive). The goal is to see if this combination is sa…

This study tests whether giving a combination of two drugs (XL-092 and pembrolizumab) before surgery can shrink tumors in people with a type of mouth cancer called oral cavity squamous cell carcinoma. The trial will include 26 adults whose cancer has not spread too far and is HPV…

This early-phase trial tests a new drug that helps the immune system recognize and attack cancer cells by blocking a 'don't eat me' signal. It is for people with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and find the ri…

This early-phase study tests a new drug, CRPA1A2, that helps the immune system attack cancer cells. It is for people with certain advanced solid tumors (like lung, esophagus, head and neck, or liver cancer) who have a specific genetic marker (HLA-A*02:01 and MAGE-A1). The main go…

This study looks at whether a special scan called SPECT-CT can help doctors decide to treat only one side of the neck with radiation in people with oropharyngeal cancer. Currently, both sides are treated to prevent hidden cancer spread, but this causes more side effects. The tria…

This early-phase study tests a combination of two drugs—decitabine (a chemotherapy that can 'reawaken' genes) and nivolumab (an immunotherapy that helps the immune system fight cancer)—in people with head and neck cancer that has returned or spread and cannot be cured with local …

This study tests whether using RECELL® (a spray made from the patient's own skin cells) on the surgical site leads to better skin color matching than standard methods. About 20 adults having head and neck reconstructive surgery will take part. The goal is to see if this approach …

This study tests whether a common antibiotic ointment applied inside the nose can reduce severe mouth and throat pain caused by radiation therapy in head and neck cancer patients. About 126 participants will receive either the antibiotic or a placebo, and neither they nor their d…

This study tests if a ketamine oral rinse can relieve pain from mouth sores (mucositis) caused by radiation therapy in head and neck cancer patients. About 62 adults receiving radiation will use the rinse and report their pain levels. The goal is to see if this simple rinse impro…

This study tests whether lowering radiation doses to certain areas can reduce side effects for people with HPV-related oropharyngeal cancer, which often has good outcomes. About 132 participants will receive either reduced lymph node radiation, reduced tumor radiation, or both, b…

This study tests whether a drug called Pedmark (sodium thiosulfate) can reduce hearing loss in adults receiving cisplatin chemotherapy for cancers like testicular, head and neck, or thoracic cancer. About 25 adults will receive Pedmark alongside their standard chemo to see if it …

This study compares two skin-care approaches to prevent or reduce painful skin reactions caused by radiation therapy in head and neck cancer patients. About 104 adults receiving TomoTherapy will be randomly assigned to use either a moisturizing cream with a foam dressing or a sil…

This study will use artificial intelligence to create a tool that predicts a person's risk of head and neck cancer. Researchers will analyze data from 3000 adults, including their medical history, lifestyle, and voice symptoms. The goal is to help doctors catch these cancers earl…

This study collects blood and tissue samples from 110 adults with advanced lung, head/neck, or mesothelioma cancers. The samples will be stored in a biobank to help scientists study genetic changes and find better ways to predict treatment outcomes. Participants donate samples bu…

This study follows 50 adults who have had head and neck cancer and now use a maxillofacial prosthesis (a custom-made artificial part for the face or mouth). Researchers will measure how well they chew, swallow, and speak, and how their quality of life changes over time. The goal …

This study tests whether a special type of CT scan (dual-energy CT) can be as good as MRI for outlining tumors and healthy organs before radiation therapy. About 80 adults with brain, bone, head/neck, or lung cancer will get both scans, and doctors will compare how accurately the…