Glow-in-the-Dark dye could save voices in thyroid surgery

NCT ID NCT07631650

Not yet recruiting Symptom relief Sponsor: Matthew Spector Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This phase 2 trial tests a dye called bevonescein that makes nerves glow during thyroid surgery, helping surgeons see and avoid them. Forty adults having thyroid removal will receive the dye before surgery. The main goal is to see if it improves voice outcomes by reducing nerve injury.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bevonescein (ALM 488) infusion
What this could lead to: If it works, this dye could help surgeons avoid damaging nerves during thyroid surgery, potentially preserving patients' voice quality.
What could go wrong: This is an early phase 2 trial with only 40 participants, so results may not apply to everyone. The dye's effectiveness and safety are still being tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms thyroid gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER HEAD AND NECK DISORDER

Contacts and locations

Locations

UMPC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States

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