HEAD AND NECK CANCER

This study tested whether proton therapy can control head and neck cancer that has come back after prior radiation. 87 adults with recurrent or new head and neck tumors that could not be surgically removed received proton re-irradiation. The goal was to see how well the treatment…

This study tested a combination of two drugs, niraparib and dostarlimab, in 10 people with head and neck cancer that had come back or spread. The goal was to see if the combination could shrink tumors or slow the cancer. Participants had to be able to swallow pills and have no ot…

This early-phase study tested whether combining an oral drug (decitabine) with an immunotherapy (durvalumab) could help people with head and neck cancer whose tumors had stopped responding to standard immunotherapy. Thirteen adults with advanced cancer participated. The goal was …

This study tested a new drug called ozuriftamab vedotin in 42 people with head and neck cancer that had come back or spread. The goal was to see if the drug could shrink tumors and to check for side effects. The study is now complete, and results will help decide if the drug shou…

This study tested whether adding tadalafil (a drug for erectile dysfunction) to pembrolizumab (an immunotherapy) could help people with advanced head and neck cancer that has spread or come back. Seven adults with this cancer took part. The goal was to see if the combination was …

This early-stage study tested a new drug called CUE-101, alone or with another drug (pembrolizumab), in 80 people with a type of head and neck cancer linked to HPV. The main goals were to check safety and find the right dose. Researchers also looked at whether the tumors shrank. …

This study looked at whether giving head and neck cancer patients a special nutritional drink (Nestle Impact AR) before and after major surgery could lower the chance of wound complications like infections or fluid buildup. Only 4 people took part, and the goal was to see if the …

This early-phase trial tested adding the immunotherapy drug pembrolizumab to standard chemo-radiation for people with advanced head and neck cancer. 59 participants received the combination to see if it was safe and how many had their tumors disappear. The goal was to improve tre…

This study tested a personalized three-step treatment for head and neck cancer that combines chemotherapy, surgery, and radiation. The goal was to see if this approach could reduce harmful side effects while still effectively controlling the disease. Forty adults with previously …

This early-stage study tested an experimental drug called CLR 131, which delivers radiation directly to cancer cells, combined with standard radiation therapy. It involved 12 people with head and neck cancer that had come back after previous treatment. The main goal was to check …

This early-stage study tested a new drug (BI 765049) alone or with another drug (ezabenlimab) in 21 Asian adults with advanced solid tumors like lung, stomach, or liver cancer. The goal was to find a safe dose and see if the drugs could shrink tumors. Participants received infusi…

This study tested whether adding the drug buparlisib to standard chemotherapy (paclitaxel) helps people with advanced head and neck cancer live longer. About 487 adults whose cancer had returned or spread and who had already tried other treatments took part. The goal was to see i…

This study tested whether personalized text messages can help head and neck cancer survivors stop drinking alcohol. Drinking raises the risk of cancer coming back, so 126 survivors from two hospitals received either tailored texts or simple feedback. The goal was to see if the te…

This study tested two new treatments (pembrolizumab alone or with epacadostat) against standard chemotherapy for people with advanced head and neck cancer that had come back or spread. The goal was to see if the new options shrank tumors better or had fewer side effects. The stud…

This early-stage study tested an experimental drug called CTX-471, given alone or with another immunotherapy (pembrolizumab), in 100 adults with advanced solid tumors that had stopped responding to standard PD-1/PD-L1 inhibitors. The main goal was to check safety and find the rig…

This early study tested a single injection of stem cells from donated umbilical cord tissue in 10 people who developed severe dry mouth after radiation for head and neck cancer. The main goal was to see if the treatment is safe, and researchers also looked for signs that it might…

This study tested a combination of chemotherapy, radiation, and a targeted drug called cetuximab in 53 patients with head and neck cancer who had a high risk of the cancer coming back after surgery. The goal was to see if this triple therapy could keep the cancer from returning f…

This study tested whether giving the immunotherapy drug pembrolizumab (MK-3475) before standard surgery could help prevent head and neck cancer from coming back. It included 67 adults with advanced, surgically removable head and neck cancer. The main goal was to see if the drug c…

This early-stage trial tested a new treatment for people with bladder, skin, or head and neck cancers that have a specific marker called MAGE-A10. Doctors took patients' own immune cells, modified them in a lab to better attack cancer, and gave them back after a short course of c…

This study tested the drug nivolumab in 39 people with head and neck cancer who had already received radiation and then had a second surgery to remove remaining cancer. The goal was to see if nivolumab is safe and helps control the disease after surgery. Participants received niv…

This study tested a new drug (TJ004309) combined with an approved immunotherapy (atezolizumab) in 25 people with advanced ovarian, head and neck, lung, gastrointestinal, or triple-negative breast cancers. The goal was to see if the combination could shrink tumors. Participants ha…

This study tested three different nutrition plans given through a feeding tube after surgery for head and neck cancer. The goal was to see which plan best prevents infections. The trial included 311 adults scheduled for tumor removal. Results help guide post-surgery care to reduc…

This study tested whether adding the targeted drug erlotinib to standard chemotherapy could better shrink head and neck tumors before surgery. About 55 adults with advanced but operable head and neck cancer took part. Researchers compared the combination to chemo plus a placebo, …

This early-phase study tested a new drug called SNB-101 in 21 people with advanced solid tumors (like colorectal, breast, or lung cancer) that had stopped responding to standard treatments. The drug is a nanoparticle version of SN-38, a chemotherapy agent, given by IV on days 1 a…

This study tested whether adding a targeted antibody (C225, also known as cetuximab) to standard chemotherapy (cisplatin) works better than chemotherapy alone for people with advanced head and neck cancer that has spread or come back. About 120 adults with incurable squamous cell…

This study tested a treatment called PepCan in 17 people who had head and neck cancer and were in remission (no signs of cancer). The goal was to see if seven injections of PepCan over two years could safely reduce the risk of cancer returning. Researchers compared PepCan to a pl…

This early-phase study tested a combination of low-dose radiation, an immunotherapy drug (tislelizumab), and a targeted therapy (afatinib) given before surgery to people with head and neck cancer. The main goal was to find a safe dose and see how well the treatment shrinks tumors…

This large phase III trial studied nearly 1,000 people with HPV-related oropharynx (throat) cancer. It compared radiation therapy combined with the targeted drug cetuximab versus standard chemoradiotherapy (radiation plus cisplatin). The goal was to see which approach works bette…

This study tested a combination of two drugs, pembrolizumab and cetuximab, in 78 people with advanced head and neck cancer that had come back or spread. The goal was to see if the combo could shrink tumors or slow the disease. Participants were grouped based on whether they had r…

This study tested a device called an artificial nose that analyzes a person's breath to detect head and neck cancer. Researchers collected breath samples from 45 people (some with cancer, some healthy) and used the device to see if it could tell the difference. The goal was to se…

This study tested whether a simple, non-invasive breath test can predict if cancer patients will benefit from immunotherapy drugs. Researchers analyzed the breath of 190 adults with lung, melanoma, bladder, kidney, or head and neck cancers to see if unique chemical patterns could…

This study tested whether watching 360° virtual reality movies can help lower fear and anxiety in cancer patients before they start radiation treatment. 292 adults with breast, lung, prostate, head and neck cancer, or brain tumors participated. Patients watched VR movies and then…

This study tested a mobile app called WeCanManage designed to help cancer survivors who have disabilities manage long-term effects of their illness and treatment. Twenty adults who had breast cancer, head and neck cancer, or sarcoma used the app and reported on their symptoms and…

This study tested whether adding a pressure biofeedback device to standard physical therapy helps people with neck pain and stiffness after neck dissection surgery for head and neck cancer. Fifty adults aged 30-50 took part. One group did special neck exercises with the device pl…

This pilot study tested a maskless immobilization device for 12 adults with head/neck cancer or brain tumors undergoing radiation therapy. The device aims to keep the head still as accurately as the standard tight plastic mask, but without the discomfort. Researchers measured how…

This study tested whether a dedicated, supervised exercise program can help head and neck cancer patients feel better physically and mentally during and after cancer treatment. 133 patients undergoing chemoradiotherapy took part. The program aimed to improve health-related qualit…

This study looked at two ways to help older patients (65+) with head and neck cancer manage side effects during radiation and chemotherapy. One approach involved a geriatric specialist working with the cancer team, and the other provided extra supportive care guided by a geriatri…

This study tested whether acupuncture can help relieve dry mouth caused by radiation therapy for head and neck cancer. 258 adults who had radiation and developed moderate to severe dry mouth took part. Participants received acupuncture, and researchers measured changes in dry mou…

This study tested a mobile app called Oleena that helps head and neck cancer patients track and manage symptoms like pain and nausea during chemoradiation. 33 patients and their healthcare providers used the app and rated how easy and helpful it was. The goal was to see if the ap…

This study looked at whether a home-based exercise program can help people with head and neck cancer maintain movement, muscle strength, and good posture while undergoing radiation therapy. Twenty-four adults who had surgery and were scheduled for radiation took part. The goal wa…

This study tested a new type of radiation therapy that adjusts the treatment each day based on the patient's current anatomy. The goal was to see if this approach could reduce long-term dry mouth (xerostomia) in people with head and neck cancer. Fifty patients were randomly assig…

This study tested two different physical therapy techniques—Kaltenborn mobilization and active release technique—to help people who developed jaw tightness and pain after radiation treatment for head and neck cancer. 115 adults who had finished radiation at least 6 months earlier…

This study looked at whether head and neck cancer patients would use medical cannabis to help manage side effects during chemoradiation. Thirty patients were followed to see how many signed up for and obtained medical cannabis. The goal was to understand if cannabis could be a pr…

This study looked at whether eating only during an 8-10 hour daytime window (without cutting calories) can improve how well immunotherapy works in people with advanced head and neck cancer. 29 patients were asked to follow this eating pattern, and researchers tracked their gut ba…

This study tested whether a simple walking program, tracked with fitness trackers, could help people with various cancers (brain, head and neck, lung, gastrointestinal, or cervical) complete their planned chemoradiotherapy without missing treatments. 166 adults who could walk ind…

This study tested a capsaicin patch (Qutenza) against a standard nerve pain pill (amitriptyline) in 13 people who had head and neck cancer and still had nerve pain after treatment. The goal was to see if the patch could lower pain by at least 2 points on a 0-10 scale over 9 month…

This study looked at whether a newer surgical robot, the da Vinci Xi, can be used to remove head and neck tumors through the mouth. 100 adults with various types of head and neck cancer were enrolled. The main goal was to see how often the surgery could be completed successfully …

This study tested a new imaging system (HyperSight CBCT) that takes pictures during cancer radiation treatment. 46 adults with various cancers (head/neck, chest, abdomen, pelvis) participated. The goal was to see if the new system provides clearer images than current methods, whi…

This study gathered information and tissue samples from 2,000 head and neck cancer patients at a single hospital in South Korea. The goal was to create a detailed registry to better understand how the disease behaves in Asian populations, since most existing research comes from W…

This study tested a new way to monitor bone flaps after head and neck reconstruction. Surgeons placed a tiny probe directly into the bone to measure key chemicals that show whether the bone is getting enough blood. The goal was to see if this method is feasible and reliable. 34 a…

This study tested a new ultrasound method to visualize the smallest blood vessels in lymph nodes on the neck. Researchers scanned 20 adults (healthy and those with head/neck cancer or lymphoma) to see if the technique can distinguish healthy from cancerous nodes. The goal was to …

This study looked at 385 adults diagnosed with their first lung or head and neck cancer to see how many kept using tobacco or alcohol during the first year. Researchers tracked smoking and drinking habits, as well as cancer progression and survival. The goal was to understand ris…

This study looked at the out-of-pocket costs and financial stress experienced by 60 adults undergoing treatment for head and neck cancer. Researchers surveyed patients to understand how these costs affect their quality of life and treatment choices. The goal was to gather informa…

This study looked at the electronic health records of 10,000 people with head and neck cancer. Researchers used artificial intelligence to find patterns that could help predict if the cancer will come back or how long someone might live. The goal is to improve future treatment de…

This study tested a new type of CT scanner that takes pictures while patients lie on the treatment couch during radiation therapy for cancer. The goal was to see if the images were clear enough to help doctors aim radiation more precisely. 41 adults with head and neck, lung, brea…

This study looked at how a common chemotherapy drug called 5-FU affects small blood vessels in cancer patients. Researchers measured blood flow in the skin of 62 people, including current and past 5-FU patients, those on other chemotherapies, and healthy volunteers. The goal was …

This study gathered information from 101 patients and healthcare providers to design a care pathway for COPD in people with lung or head and neck cancer. The goal was to reduce treatment burden and overcome common barriers to COPD care in community oncology clinics. Researchers u…

This study used a special full-body PET scanner to watch how a radioactive sugar moves through head and neck cancer and radiation-caused inflammation over time. Seven adults with stage II-IVa oral cancer took part after completing radiation therapy. The goal was to learn more abo…

This study tested a smartphone-based platform to monitor quality of life in 410 head and neck cancer survivors after curative treatment. The goal was to see if the tool could detect meaningful declines in well-being earlier and more easily than standard methods. Participants used…

This study tested whether a non-invasive imaging technique called OCT can detect early, invisible skin damage caused by radiation therapy in 30 head and neck cancer patients. Researchers compared OCT images taken before and during treatment to see if they could spot changes befor…

This study measured levels of a protein called CGRP in the blood of 23 people with head and neck cancer during their radiation treatment. The goal was to see if changes in CGRP are linked to pain caused by radiation. The results could help doctors better understand and manage tre…

This study looked at 160 people with head and neck cancer who needed a diagnostic exam called panendoscopy under general anesthesia. Researchers compared standard oxygen therapy with a high-flow system called THRIVE (Optiflow) to see which one better prevents drops in oxygen leve…

This study looked at 28 head and neck cancer patients to see if neck endurance is linked to swallowing problems and breathing function. Researchers measured neck strength, swallowing ability, and mouth pressure. The goal was to find new ways to design rehabilitation programs for …