Mouth spray may soothe painful sores from cancer radiation
NCT ID NCT07467759
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a benzydamine hydrochloride (Difflam) oral spray can reduce the severity of mouth sores caused by high-dose radiation in head and neck cancer patients. Thirty-five adults receiving radiation without chemotherapy were randomly assigned to standard mouth care or standard care plus the spray for six weeks. Researchers tracked soreness weekly using a standard scale to see if the spray helped.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
benzydamine hydrochloride (Difflam) oral spray
What this could lead to
If it works, this spray could become a standard way to reduce painful mouth sores during radiation therapy for head and neck cancer.
What could go wrong
This is a small, single-center trial with only 35 participants, so results may not apply to everyone. The spray may not work better than standard care alone.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Pharmacy, Latakia university
Latakia, Syria