Your DNA might predict radiation side effects

NCT ID NCT02489084

Completed Knowledge-focused Sponsor: University Medical Center Groningen Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at whether a person's genetic makeup can help predict which head and neck cancer patients will experience side effects from radiation therapy, such as difficulty swallowing, dry mouth, and other complications. Researchers will collect blood samples from about 2000 patients to analyze genetic variations and see if they improve existing prediction models. The goal is to enable more personalized radiation treatment plans that minimize harm to healthy tissue.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Blood sampling for genetic analysis
What this could lead to: If genetic profiles improve prediction, doctors could tailor radiation plans to each patient, potentially reducing side effects like swallowing problems and dry mouth.
What could go wrong: The study is observational and exploratory, so it may not find reliable genetic links. Even if found, the models need validation before changing clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER

Contacts and locations

Locations

University Medical Center Groningen

Groningen, Provincie Groningen, 9700RB, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.