HEAD AND NECK CANCER

This phase 3 trial tests whether adding the chemotherapy drug carboplatin to standard palliative radiotherapy helps control tumor growth and reduce pain better than radiotherapy alone. The study includes adults with advanced lung or head and neck cancer who need palliative radiat…

This phase II trial tested two drug combinations—ibrutinib plus nivolumab or ibrutinib plus cetuximab—in patients with recurrent or metastatic head and neck squamous cell carcinoma. The goal was to see if these combinations could shrink tumors or slow disease progression. However…

This early-stage trial tested an experimental drug called xevinapant combined with standard chemotherapy and radiation in people with head and neck cancer who cannot take the usual drug cisplatin. The goal was to find the safest dose of xevinapant. The study was terminated early,…

This early-phase study tested a new drug called PF-07921585, given alone or with another drug (sasanlimab), in adults with advanced solid tumors like lung, bladder, kidney, melanoma, head & neck, or colorectal cancer. The goal was to check safety and find the right dose. Only 4 p…

This study looked at whether a structured smoking cessation program starting four weeks before surgery could reduce complications in smokers undergoing intermediate to high-risk operations. Researchers planned to enroll 251 adult smokers scheduled for surgeries like abdominal, th…

This study tested whether adding the drug xevinapant to standard radiation therapy could help prevent head and neck cancer from coming back after surgery. It included 166 people with high-risk cancer who could not take the usual chemotherapy drug cisplatin. The trial was stopped …

This phase 2 trial tested a combination of two drugs, niraparib and dostarlimab, in 51 adults with advanced solid tumors that had DNA repair defects or were sensitive to platinum chemotherapy. The goal was to see if the combo could shrink tumors. However, the study was terminated…

This early-stage study tested a new drug called BDC-3042, alone or with another drug (cemiplimab), in 17 people with advanced cancers like breast, kidney, ovarian, head and neck, colorectal, lung, or melanoma. The main goal was to check safety and find the right dose. The study w…

This study tested a drug called niraparib in 22 adults with advanced solid tumors (like breast, lung, or pancreatic cancer) that have a specific genetic change called a PALB2 mutation. The goal was to see if the drug could shrink tumors or slow cancer growth. The study was stoppe…

This study aimed to see if a smartphone app called IONA Mind could help treat depression in people who have had head and neck cancer. Participants would use the app for 6 weeks and fill out surveys. However, the trial was terminated early after enrolling only 1 person, so no mean…

This early-phase study aimed to see if adding the drug xevinapant to standard chemoradiotherapy is safe for people with advanced head and neck cancer that cannot be removed by surgery. The study planned to enroll 18 participants but was terminated early. The main focus was on sid…

This study tested whether a special oral care routine (dental cleaning and mouth treatment) could reduce severe mouth sores in people getting radiation for head and neck cancer. About 60 adults were planned to join, but the study was stopped early. The goal was to see if this app…

This study tested whether a web-based screening tool could help monitor depression and distress in adults who had surgery for new head and neck cancer. Participants were randomly assigned to use the tool or receive usual care. The goal was to see if the tool led to more timely me…

This study aimed to find the best way to follow up with patients after they finish curative treatment for head and neck cancer. Researchers compared a personalized follow-up schedule, tailored to each patient's needs, with the usual one-size-fits-all approach. The goal was to see…