Head and neck cancer drug combo safety trial halted early

NCT ID NCT06056310

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-phase study aimed to see if adding the drug xevinapant to standard chemoradiotherapy is safe for people with advanced head and neck cancer that cannot be removed by surgery. The study planned to enroll 18 participants but was terminated early. The main focus was on side effects and tolerability.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma laryngeal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Avera McKennan Hospital and University Health Center

    Sioux Falls, South Dakota, 57105, United States

  • Centre Hospitalier de l'Ardenne - PARENT

    Libramont, Belgium

  • China Medical University Hospital

    Taichung, Taiwan

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Clinica Universidad de Navarra (MAD) - Oncology Service

    Madrid, Spain

  • Hadassah University Hospital - Ein Kerem

    Jerusalem, Israel

  • Hospital Universitario Fundacion Jimenez Diaz - Oncology

    Madrid, Spain

  • Hospital Universitario Virgen del Rocio - Oncology Service

    Seville, Spain

  • ICO Girona - Hospital Universitari de Girona Dr Josep Trueta - Servicio de Oncologia Medica

    Girona, Spain

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, Taiwan

  • Karmanos Cancer Institute - PARENT

    Detroit, Michigan, 48201, United States

  • Konkuk University Medical Center

    Seoul, South Korea

  • Montefiore Medical Center PRIME

    The Bronx, New York, 10467, United States

  • Mount Sinai Comprehensive Cancer Center

    Miami Beach, Florida, 33140, United States

  • National Taiwan University Hospital

    Taipei, Taiwan

  • Pusan National University Hospital

    Busan, South Korea

  • Pusan National University Yangsan Hospital

    Yangsan, South Korea

  • Seoul National University Bundang Hospital

    Seongnam, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, South Korea

  • Taipei Veterans General Hospital

    Taipei, Taiwan

  • Universitair Ziekenhuis Gent - Medical Oncology

    Ghent, Belgium

  • Uza - Parent

    Edegem, Belgium

  • Vitaz

    Sint-Niklaas, Belgium