Could a silver solution save cancer Patients' teeth?

NCT ID NCT05403125

Completed Disease control Sponsor: Texas A & M University Baylor College Of Dentistry Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This early-phase trial tested whether a special fluoride treatment (silver diamine fluoride) can prevent tooth decay in 56 head and neck cancer patients undergoing radiation therapy. Patients received a one-time professional application of the silver solution plus a fluoride gel for home use. The study aimed to see if this simple addition to dental care could reduce cavities and improve quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: silver diamine fluoride (38%) and sodium fluoride gel (5000 ppm)
What this could lead to: If it works, this could offer a simple way to prevent severe tooth decay in head and neck cancer patients receiving radiation.
What could go wrong: This is a very early, small pilot study (56 participants) with no results yet. It may not show clear benefit or be generalizable to all patients.

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Conditions

The condition(s) this trial relates to.

dental caries head and neck cancer pharynx cancer Xerostomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DENTAL CARIES

Contacts and locations

Locations

Baylor College of Dentistry

Dallas, Texas, 75246, United States

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