Can a triple therapy shrink head and neck tumors before surgery?
NCT ID NCT07732634
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether a new drug called RiMO-301, given alongside radiation and the immunotherapy pembrolizumab (Keytruda), can shrink tumors before surgery in people with resectable, locally advanced head and neck cancer. The study will measure how many patients' tumors respond to this pre-surgery treatment and track survival for up to two years. About 20 participants will receive the combination therapy before undergoing surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of an experimental drug called RiMO-301, radiation therapy, and the immunotherapy drug pembrolizumab (Keytruda)
- What this could lead to
- If successful, this approach could shrink tumors before surgery, potentially improving outcomes for people with locally advanced head and neck cancer.
- What could go wrong
- This is a small, early-phase trial, so results may not apply to all patients. The combination therapy may cause side effects, and it is not yet known if it will improve survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEAD AND NECK CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Illinois at Chicago
Chicago, Illinois, 60612, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Radiation's hidden toll: could it link tinnitus and hearing loss in cancer survivors?
- Can tailored nutrition boost recovery from head and neck surgery?
- Can less radiation be safer for throat cancer?
- Can Pre-Surgery immunotherapy prime the immune system to fight head and neck cancer?
- Can a new drug boost the power of chemoradiation against head and neck cancer?
- Exercise after cancer therapy: a new way to gauge prognosis?